DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and ZNF224

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001308574.1	Gene:	ZNF224 / 7767	HGNCID:	13017	Length:	707	Species:	Homo sapiens

Alignment Length:	685	Identity:	176/685 - (25%)
Similarity:	264/685 - (38%)	Gaps:	189/685 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TFHCMCCAEFFVHPLALYQHMNTLHPHEPGNG---QQEQESPGDESEDYSWIFEPVCE-LAEDGS 107
            |||       |:....::. |.|....|..:|   |.|.|:..:......|.|:.:.| :|.|.:
Human    56 TFH-------FLREEKIWM-MKTAIQREGNSGDKIQTEMETVSEAGTHQEWSFQQIWEKIASDLT 112

  Fly   108 DSSDGSASSGSDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPT---TSNSNTQQSQESVQP 169
            .|.|...:|   |..|.:.|.....:...|...:...||..:...|:   .|:.:..|...|.:.
Human   113 RSQDLMINS---SQFSKEGDFPCQTEAGLSVIHTRQKSSQGNGYKPSFSDVSHFDFHQQLHSGEK 174

  Fly   170 LHGL-----------------------------VAGPGYNEFQLQMTDPRESTSIFMVQPTVSVT 205
            .|..                             |.|..:::.....|..|..|.
Human   175 SHTCDECGKNFCYISALRIHQRVHMGEKCYKCDVCGKEFSQSSHLQTHQRVHTG----------- 228

  Fly   206 PLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIG-------------------APVMDPALNGNQ 251
                 ..|...|..|.|.         .|||.:.                   |.:.|..|..:|
Human   229 -----EKPFKCVECGKGF---------SRRSALNVHHKLHTGEKPYNCEECGKAFIHDSQLQEHQ 279

  Fly   252 ------KCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPY 310
                  |.|:|..|..||.....|::|...|...|||:|..|.|:|....:||:|..||:|||||
Human   280 RIHTGEKPFKCDICGKSFCGRSRLNRHSMVHTAEKPFRCDTCDKSFRQRSALNSHRMIHTGEKPY 344

  Fly   311 KCE----------------------------LCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGF 347
            |||                            .|.|:|..:|.|:.|.|.||..||.:|.:|.|||
Human   345 KCEECGKGFICRRDLYTHHMVHTGEKPYNCKECGKSFRWASCLLKHQRVHSGEKPFKCEECGKGF 409

  Fly   348 INYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQ 412
            ...|....||::| :..:.:.|.||.:.:|....||.|.|:||.|.:|.|..|.::|..:..|::
Human   410 YTNSQCYSHQRSH-SGEKPYKCVECGKGYKRRLDLDFHQRVHTGEKLYNCKECGKSFSRAPCLLK 473

  Fly   413 HMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEK 477
            |.:.|.|||||.|..|.:.|||:..|:.|.|:||||||::|:.|.|.:....:|.:|.|:|.||:
Human   474 HERLHSGEKPFQCEECGKRFTQNSHLHSHQRVHTGEKPYKCEKCGKGYNSKFNLDMHQKVHTGER 538

  Fly   478 PYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALAS 542
            ||.|..||||:...:.|.||.:.|.               .::|.:   |..||......:.|.|
Human   539 PYNCKECGKSFGWASCLLKHQRLHS---------------GEKPFK---CEECGKRFTQNSQLHS 585

  Fly   543 H--VHSQHAALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYVERVQC------VLQQMNHQQQHQ 599
            |  ||:                   |..| .||.           :|      ...::.||   :
Human   586 HQRVHT-------------------GEKP-YKCD-----------ECGKGFSWSSTRLTHQ---R 616

  Fly   600 QHQQQPPQQQQQHPQ---QQQQQHLQQQPHQMQLP 631
            :|.::.|.:.:||.:   |.....:|::.|.::.|
Human   617 RHSRETPLKCEQHGKNIVQNSFSKVQEKVHSVEKP 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	64/186 (34%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	10/24 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	16/52 (31%)
		zf-C2H2_2	312..>387	CDD:289522	29/102 (28%)
		C2H2 Zn finger	312..332	CDD:275368	9/47 (19%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	12/24 (50%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
ZNF224	NP_001308574.1	KRAB	8..67	CDD:214630	4/17 (24%)
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	178..198	CDD:275368	0/19 (0%)
		COG5048	202..641	CDD:227381	143/516 (28%)
		C2H2 Zn finger	206..226	CDD:275368	4/19 (21%)
		zf-H2C2_2	218..243	CDD:290200	7/49 (14%)
		C2H2 Zn finger	234..254	CDD:275368	6/28 (21%)
		C2H2 Zn finger	262..282	CDD:275368	4/19 (21%)
		zf-H2C2_2	275..297	CDD:290200	6/21 (29%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	346..366	CDD:275368	2/19 (11%)
		C2H2 Zn finger	374..394	CDD:275368	7/19 (37%)
		C2H2 Zn finger	402..422	CDD:275368	8/19 (42%)
		C2H2 Zn finger	430..450	CDD:275368	8/19 (42%)
		C2H2 Zn finger	458..478	CDD:275368	5/19 (26%)
		zf-H2C2_2	471..495	CDD:290200	11/23 (48%)
		C2H2 Zn finger	486..506	CDD:275368	8/19 (42%)
		C2H2 Zn finger	514..534	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..549	CDD:290200	12/22 (55%)
		C2H2 Zn finger	542..562	CDD:275368	8/19 (42%)
		zf-H2C2_2	555..579	CDD:290200	8/41 (20%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..606	CDD:290200	9/51 (18%)
		C2H2 Zn finger	598..618	CDD:275368	4/33 (12%)
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000