Protein Alignment CG12299 and ZNF146

DIOPT Version :10

• Sequence 1: NP_609448.1
• Gene: CG12299 / 34483
• FlyBaseID: FBgn0032295
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_009076.2
• Gene: ZNF146 / 7705
• HGNCID: 12931
• Length: 292
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 109/295 - (36%)
• Similarity: 169/295 - (57%)
• Gaps: 24/295 - (8%)

  Fly   254 FQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKA 318
            |.|..|...|.:..:|::|...|...|||:|:.|.|.|:....:..|...|:|||.::|..|.|:
Human    16 FACKVCGKVFSHKSNLTEHEHFHTREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKS 80

  Fly   319 FTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLD 383
            |:|..:|:.|.:.|:..||.:|..|.|.||..|:|:.||:||.. .:.|:|.||.:.|..::.|.
Human    81 FSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTG-EKPFVCKECGKTFSGKSNLT 144

  Fly   384 EHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGE 448
            ||.::|..|..::|:.|..||.....|::|...|.||||:.|:.|.::|:|..||.:|:|||:|:
Human   145 EHEKIHIGEKPFKCSECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGD 209

  Fly   449 KPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSP 513
            ||::|.:|.|.|:|:|||:||::.|.|||||.|..|||::||.:.|..|::.|
Human   210 KPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIH------------ 262

  Fly   514 GLLVAKQPHETLVCIVCGSLHADATALASHVHSQH 548
               ..|:|::   |..||.    |.:..|| |.:|
Human   263 ---TGKKPYQ---CSECGK----AFSQKSH-HIRH 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	245..>501	CDD:227381	98/246 (40%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		C2H2 Zn finger	284..304	CDD:275368	5/19 (26%)
		zf-H2C2_2	296..321	CDD:463886	9/24 (38%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:463886	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:463886	13/24 (54%)
		C2H2 Zn finger	453..473	CDD:275368	10/19 (53%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
ZNF146	NP_009076.2	COG5048	<1..260	CDD:227381	98/244 (40%)
		C2H2 Zn finger	18..38	CDD:275368	5/19 (26%)
		C2H2 Zn finger	46..66	CDD:275368	5/19 (26%)
		C2H2 Zn finger	74..94	CDD:275368	7/19 (37%)
		C2H2 Zn finger	102..122	CDD:275368	9/19 (47%)
		C2H2 Zn finger	130..150	CDD:275368	7/19 (37%)
		C2H2 Zn finger	158..178	CDD:275368	6/19 (32%)
		C2H2 Zn finger	186..206	CDD:275368	8/19 (42%)
		Interaction with TERF2IP. /evidence=ECO:0000269|PubMed:15838871	212..292		35/98 (36%)
		C2H2 Zn finger	214..234	CDD:275368	10/19 (53%)
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		zf-H2C2_2	255..279	CDD:463886	9/45 (20%)
		C2H2 Zn finger	270..290	CDD:275368	8/22 (36%)