DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and ZNF143

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_005253178.1	Gene:	ZNF143 / 7702	HGNCID:	12928	Length:	653	Species:	Homo sapiens

Alignment Length:	670	Identity:	156/670 - (23%)
Similarity:	248/670 - (37%)	Gaps:	153/670 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PGNGQQEQE-----------SPGDESEDYSWIFEPVCELAEDGSDS------------------- 109
            ||.|.:.|.           :.||..|:...:......|| |||.:
Human    32 PGGGMEAQHVTLCLTEAVTVADGDNLENMEGVSLQAVTLA-DGSTAYIQHNSKDAKLIDGQVIQL 95

  Fly   110 SDGSAS---------SGSDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTT--SNSNTQQS 163
            .||||:         |..||....|......:|.:::....:|..|...|::...  .:..|...
Human    96 EDGSAAYVQHVPIPKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSALQAVQLEDGTTAYI 160

  Fly   164 QESVQ----------PLHGLVAGPGYNEFQLQMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVS 218
            ..:||          ...|.|||....:..:   ||...:::......||:...:.:
Human   161 HHAVQVPQSDTILAIQADGTVAGLHTGDATI---DPDTISALEQYAAKVSIDGSESV-------- 214

  Fly   219 PGLGLQSTPIKRRR------GRRSNIGAPVMDPALNGNQKCFQCTH--CEASFPNAGDLSKHVRS 275
            .|.|:.....:.::      |..:.:.|    .:....:|.|:|.:  |...:..|..|..|.||
Human   215 AGTGMIGENEQEKKMQIVLQGHATRVTA----KSQQSGEKAFRCEYDGCGKLYTTAHHLKVHERS 275

  Fly   276 HITNKPFQC--SICQKTFTHIGSLNTHIRIHSGEKPYKC--ELCPKAFTQSSSLMVHMRSHSVRK 336
            |..::|:||  :.|.|.|.....|.:|:|.|:|||||:|  :.|.|:|..|..|..|:|:|:..:
Human   276 HTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGER 340

  Fly   337 PHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAI-- 399
            |.:|                      |.|     .|.|.|....:...|:|.||.|..|.|..
Human   341 PFKC----------------------PFE-----GCGRSFTTSNIRKVHVRTHTGERPYYCTEPG 378

  Fly   400 CREAFRASSELVQHMKNHMGEKPFTCSL--CDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQ 462
            |..||.:::....|::.|.||||:.|::  ||:.||:..||..|..:||..||:.|..|.|.:.|
Human   379 CGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQ 443

  Fly   463 ASSLSVHMK-IHAGEKPY---------PCPICGKSY---SQQAYL----NKHIQAHQMASAASAS 510
            .|:|::|.: .|...:|.         |.|..|:..   ||..|:    ...:.:.|:|:...:.
Human   444 ISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGEDVLKGSQITYVTGVEGDDVVSTQVATVTQSG 508

  Fly   511 TSPGLLVAKQPHETLVCIVCGSLHA----------DATALASHVHSQHAALLDTMKQSGMNTAPG 565
            .|..:.:..|.....|.|....:.|          |.|.:....|....:...| ....|.||.|
Human   509 LSQQVTLISQDGTQHVNISQADMQAIGNTITMVTQDGTPITVPAHDAVISSAGT-HSVAMVTAEG 572

  Fly   566 GAIPDVKCSAEEQQAYVERVQCVLQQMNHQQQHQQH----QQQP------PQQQQQHPQQQQQQH 620
            .....|...|::..|:    .....:|.| |||..|    :.:|      ....|...|..:|..
Human   573 TEGEQVAIVAQDLAAF----HTASSEMGH-QQHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPS 632

  Fly   621 LQQQPHQMQLPQQPKLPAMD 640
            |::........||.:.|.:|
Human   633 LEEAIRIASRIQQGETPGLD 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	50/166 (30%)
		C2H2 Zn finger	256..276	CDD:275368	6/21 (29%)
		zf-H2C2_2	268..293	CDD:290200	11/26 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/21 (33%)
		zf-H2C2_2	296..321	CDD:290200	13/26 (50%)
		zf-C2H2_2	312..>387	CDD:289522	17/76 (22%)
		C2H2 Zn finger	312..332	CDD:275368	8/21 (38%)
		C2H2 Zn finger	340..360	CDD:275368	1/19 (5%)
		C2H2 Zn finger	369..389	CDD:275368	5/19 (26%)
		C2H2 Zn finger	397..417	CDD:275368	5/21 (24%)
		zf-H2C2_2	409..434	CDD:290200	10/26 (38%)
		C2H2 Zn finger	425..445	CDD:275368	8/21 (38%)
		zf-H2C2_2	437..462	CDD:290200	10/24 (42%)
		C2H2 Zn finger	453..473	CDD:275368	7/20 (35%)
		zf-H2C2_2	465..490	CDD:290200	7/37 (19%)
		C2H2 Zn finger	481..501	CDD:275368	5/26 (19%)
ZNF143	XP_005253178.1	Trp-synth-beta_II	<97..207	CDD:294246	21/112 (19%)
		C2H2 Zn finger	254..276	CDD:275368	6/21 (29%)
		zf-H2C2_2	268..295	CDD:290200	11/26 (42%)
		COG5048	279..>337	CDD:227381	23/57 (40%)
		C2H2 Zn finger	284..306	CDD:275368	7/21 (33%)
		zf-H2C2_2	299..325	CDD:290200	13/25 (52%)
		zf-C2H2_8	314..429	CDD:292531	42/141 (30%)
		C2H2 Zn finger	314..336	CDD:275368	8/21 (38%)
		zf-H2C2_2	328..355	CDD:290200	11/53 (21%)
		C2H2 Zn finger	344..366	CDD:275368	8/48 (17%)
		zf-H2C2_2	360..385	CDD:290200	10/24 (42%)
		C2H2 Zn finger	374..396	CDD:275368	5/21 (24%)
		zf-H2C2_2	388..414	CDD:290200	9/25 (36%)
		C2H2 Zn finger	404..426	CDD:275368	8/21 (38%)
		C2H2 Zn finger	434..453	CDD:275368	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000