Protein Alignment CG12299 and ZNF142

DIOPT Version :10

• Sequence 1: NP_609448.1
• Gene: CG12299 / 34483
• FlyBaseID: FBgn0032295
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_001353219.1
• Gene: ZNF142 / 7701
• HGNCID: 12927
• Length: 1887
• Species: Homo sapiens
• Alignment Length: 954
• Identity: 193/954 - (20%)
• Similarity: 290/954 - (30%)
• Gaps: 330/954 - (34%)

  Fly     6 KQSYHHLPLTITPILQQTHLLPQQA------------PNPPQQQPQQPQ-PPDLTFHCMCCAEFF 57
            :||:....|.......:||:.|.|.            .||....|.|.| ||.....|..|.:.|
Human   109 EQSFAEPTLLALHQCSETHIQPVQGLSSPPCSVELPPSNPTLPGPLQGQSPPVSPLSCPVCRQEF 173

  Fly    58 VHPLALYQHMNTLHPHEPGNGQQEQESPGDESEDYSWIFE---------PV------CEL---AE 104
            ..|.||..|.. :|...|......:......:||...:..         ||      |.|   ::
Human   174 AQPQALKSHFK-IHRGTPDTFSCPESGCVFSAEDRKGLQHHLRQTHRAVPVPCSFRGCPLLFGSQ 237

  Fly   105 DGSD----------------------------SSDGSASSGSDSSSSSDDDDDDDDDDSSSSSSS 141
            .|.:                            .|.|:.:.|                   ..|:.
Human   238 QGMELHRQAHYPFHCSHCSFIGSNVKLFRQHQRSHGAGTQG-------------------ELSAV 283

  Fly   142 SSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTDPRESTSIFMVQPTVSVTP 206
            ....|......|.......:.|||:..||.|.......|..:.:.:|.::.:.
Human   284 QGLPSQELLPAPKLPPGEREPSQEAGTPLPGQETAEEENVEKEEKSDTQKDSQ------------ 336

  Fly   207 LQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNGNQKCFQ---CTHCEASFPNAGD 268
                    ..|..|.|.|     |..|           ..::|.:..|:   |..|:..|.....
Human   337 --------KAVDKGQGAQ-----RLEG-----------DVVSGTESLFKTHMCPECKRCFKKRTH 377

  Fly   269 LSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEK------------------------- 308
            |.:|:..|..:...||..|||.||....|.||:....|||
Human   378 LVEHLHLHFPDPSLQCPNCQKFFTSKSKLKTHLLRELGEKAHHCPLCHYSAVERNALNRHMASMH 442

  Fly   309 ---------PYKCELCPKAFTQSSSLMVHMRSHSVRK-----PHQCVQ--CD------KGFINY- 350
                     .|.|.:|.:.|..|.:|..|::||:...     |.:|.|  |.      |.||.:
Human   443 EDISNFYSDTYACPVCREEFRLSQALKEHLKSHTAAAAAEPLPLRCFQEGCSYAAPDRKAFIKHL 507

  Fly   351 -----------------------SSLLLHQKTHIAPTETFICPECE---------REFKAE---- 379
                                   .::..|.|:|.|    |.||.|:         |:.|.:
Human   508 KETHGVRAVECRHHSCPMLFATAEAMEAHHKSHYA----FHCPHCDFACSNKHLFRKHKKQGHPG 568

  Fly   380 -----------------ALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSL 427
                             |..|...:||..|.::||..|..|......|::||..|.||||..|.|
Human   569 SEELRCTFCPFATFNPVAYQDHVGKMHAHEKIHQCPECNFATAHKRVLIRHMLLHTGEKPHKCEL 633

  Fly   428 CDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQA 492
            ||.:......|:.||..|:..|.:.|..|.........|.|||:.|||:..|.|..|.....:..
Human   634 CDFTCRDVSYLSKHMLTHSNTKDYMCTECGYVTKWKHYLRVHMRKHAGDLRYQCNQCSYRCHRAD 698

  Fly   493 YLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQ 557
            .|:.|...||                   .::|:|.||.........|..|:.|||
Human   699 QLSSHKLRHQ-------------------GKSLMCEVCAFACKRKYELQKHMASQH--------- 735

  Fly   558 SGMNTAPGGAIPDVKC-----SAEEQQAYVERVQCVLQQMN-------------------HQQQH 598
                 .||...|...|     .:..:||.:....|...::.                   |::
Human   736 -----HPGTPAPLYPCHYCSYQSRHKQAVLSHENCKHTRLREFHCALCDYRTFSNTTLLFHKR-- 793

  Fly   599 QQHQQQPPQQ--QQQHPQQQQQQHLQ-------QQPHQMQLPQQPKLPAMD-----STGEDEEEP 649
            :.|...|..|  |.::..|:.:..:|       .:|.. ||..:|:.|..:     ....|:..|
Human   794 KAHGYVPGDQAWQLRYASQEPEGAMQGPTPPPDSEPSN-QLSARPEGPGHEPGTVVDPSLDQALP 857

  Fly   650 DEAEEPPDEEEEQDE---------PEEPAEVK-------TEVLAAE-DALTNPGYPI-------- 689
            :.:||.....:|..|         ...||||:       .|.|..| :::|.|  |:
Human   858 EMSEEVNTGRQEGSEAPHGGDLGGSPSPAEVEEGSCTLHLEALGVELESVTEP--PLEEVTETAP 920

  Fly   690 -----LGLQEEQILLDSDM-YYEDFGDMDVGCQEEVFGDFVVNE 727
                 |||:....|...:: .:|..|..|:..:|....:..|:|
Human   921 MEFRPLGLEGPDGLEGPELSSFEGIGTSDLSAEENPLLEKPVSE 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	245..>501	CDD:227381	87/359 (24%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..321	CDD:463886	10/58 (17%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	8/51 (16%)
		C2H2 Zn finger	369..389	CDD:275368	7/49 (14%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:463886	12/24 (50%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:463886	7/24 (29%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..501	CDD:275368	4/19 (21%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		C2H2 Zn finger	421..438	CDD:275368	0/16 (0%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..566	CDD:275368	5/20 (25%)
		C2H2 Zn finger	574..595	CDD:275368	2/20 (10%)
		zf-H2C2_5	601..625	CDD:404746	8/23 (35%)
		C2H2 Zn finger	603..623	CDD:275368	6/19 (32%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		C2H2 Zn finger	659..679	CDD:275368	6/19 (32%)
		C2H2 Zn finger	687..707	CDD:275368	4/19 (21%)
		C2H2 Zn finger	714..731	CDD:275368	4/16 (25%)
		PHA03247	928..>1219	CDD:223021	8/37 (22%)
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368
		zf-H2C2_2	1694..1718	CDD:463886
		C2H2 Zn finger	1710..1730	CDD:275368
		zf-H2C2_2	1723..1747	CDD:463886
		C2H2 Zn finger	1738..1759	CDD:275368
		C2H2 Zn finger	1767..1787	CDD:275368
		C2H2 Zn finger	1795..1815	CDD:275368
		C2H2 Zn finger	1823..1843	CDD:275368