DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zbtb49

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_083438.1	Gene:	Zbtb49 / 75079	MGIID:	1922329	Length:	756	Species:	Mus musculus

Alignment Length:	480	Identity:	135/480 - (28%)
Similarity:	193/480 - (40%)	Gaps:	118/480 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SSVPTTSNSNTQQSQ------ESVQPLHGLVAGPGYNEFQLQMTDPRESTSIFMVQPT------V 202
            |.||.|....|:.:.      :|..|:.|..|         .:..|....|.|:..|.      .
Mouse   227 SQVPATQQPLTRSASTDLAAADSQPPVEGRPA---------VLETPEHLPSTFVAPPVRNSGNDS 282

  Fly   203 SVTPLQQLLPPA----------------------------PTVSPGL----------------GL 223
            ...||.:  |||                            |....||                |.
Mouse   283 EADPLSE--PPAKQMRLKKAMHLKKLNFLKSQQSAECTSHPEPDNGLARREESAAKEDAVERAGS 345

  Fly   224 QSTPIKRR------RGRRSNI-GAPVM--DP--ALNGNQKCFQCTHCEASFPNAGDLSKHVRSHI 277
            |:...|.|      ..|...: |||..  ||  ||. .||.:.|..|...|.:..:|..|.|||.
Mouse   346 QTAEEKGRGELGPESSREEELPGAPASWEDPSQALQ-PQKQYACELCGKPFKHPSNLELHKRSHT 409

  Fly   278 TNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQ 342
            ..|||:|:||.|.|:..|:|.||:|.|||||||.||:|.|.|..|..:..|:..||..|||.|..
Mouse   410 GEKPFECNICGKHFSQAGNLQTHLRRHSGEKPYICEICGKRFAASGDVQRHIIIHSGEKPHLCDT 474

  Fly   343 CDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRAS 407
            |.:||.|:|:|..|:||                             ||.:.|:.|..|.::|...
Mouse   475 CGRGFSNFSNLKEHKKT-----------------------------HTADKVFTCDECGKSFNMQ 510

  Fly   408 SELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKI 472
            .:||:|...|.||:|::|..|.:.|..||.|..|:|.||||||:.|::|.||||:::.|..|.::
Mouse   511 RKLVKHRVRHTGERPYSCPACGKCFGGSGDLRRHVRTHTGEKPYSCEVCSKCFTRSAVLRRHKRM 575

  Fly   473 HAGEKPYPCPICGKSYSQQAYLNKHIQAHQM-ASAASASTSPGLLVAKQPHETLVCIVCGSLHAD 536
            |.........:.|:       |::.|:...: .|.:|.|.|..:.|...|  ..|.:....:.:.
Mouse   576 HGRADARSPVVLGE-------LSRPIEPSDLDRSQSSDSFSQDVSVTLMP--VSVKLPVQPVESS 631

  Fly   537 ATALASHVHSQHAALLDTMKQSGMN 561
            ......|....:..|...::..||:
Mouse   632 VAGFDGHCSGSYCKLRSMLRPPGMS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	58/158 (37%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	13/24 (54%)
		C2H2 Zn finger	284..304	CDD:275368	10/19 (53%)
		zf-H2C2_2	296..321	CDD:290200	16/24 (67%)
		zf-C2H2_2	312..>387	CDD:289522	22/74 (30%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	369..389	CDD:275368	0/19 (0%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:290200	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	14/24 (58%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	4/24 (17%)
		C2H2 Zn finger	481..501	CDD:275368	3/19 (16%)
Zbtb49	NP_083438.1	BTB	15..118	CDD:279045
		BTB	26..119	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..197
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..290		15/73 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..379		13/67 (19%)
		COG5048	<376..576	CDD:227381	90/229 (39%)
		zf-C2H2	386..408	CDD:278523	6/21 (29%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..425	CDD:290200	13/24 (54%)
		C2H2 Zn finger	416..436	CDD:275368	10/19 (53%)
		zf-H2C2_2	428..452	CDD:290200	15/23 (65%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		zf-H2C2_2	456..481	CDD:290200	10/24 (42%)
		C2H2 Zn finger	472..492	CDD:275368	10/48 (21%)
		zf-H2C2_2	484..508	CDD:290200	9/52 (17%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		zf-H2C2_2	513..535	CDD:290200	9/21 (43%)
		C2H2 Zn finger	528..548	CDD:275368	8/19 (42%)
		zf-H2C2_2	540..565	CDD:290200	14/24 (58%)
		C2H2 Zn finger	556..576	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910