DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Gtf3a

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_079928.2	Gene:	Gtf3a / 66596	MGIID:	1913846	Length:	364	Species:	Mus musculus

Alignment Length:	433	Identity:	107/433 - (24%)
Similarity:	162/433 - (37%)	Gaps:	129/433 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 PALNGNQKCFQCT--HCEASFPNAGDLSKHVRSHITNKPFQCSI--CQKTFTHIGSLNTHIRIHS 305
            |||...   |.|:  .|.||:..|..|..|:..|...:||.|..  |.|.|.....|:.|:.||:
Mouse    32 PALPSR---FICSFPDCSASYNKAWKLDAHLCKHTGERPFVCDYEGCGKAFIRDYHLSRHVLIHT 93

  Fly   306 GEKPYKC--ELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFI 368
            ||||:.|  :.|.:.|...|:|..|:                           ::.|..|.:.::
Mouse    94 GEKPFVCADDGCNQKFNTKSNLKKHI---------------------------ERKHGNPQKQYV 131

  Fly   369 C--PECEREFKAEALLDEHMRMHTQELVYQCAI--CREAFRASSELVQHMKNHMG---EKPFTCS 426
            |  ..|::.||....|..|...||.|.:::|..  |.:.|.:.|.|.:|.|.|.|   :|  .||
Mouse   132 CSYEGCKKAFKKHQQLRTHQCQHTSEPLFRCTHEGCGKHFASPSRLKRHGKVHEGYLCQK--GCS 194

  Fly   427 LCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKP-YPCPI--CGKSY 488
            ...:::|:   |..||| ...::...|.:|.:.|.:...|..|||.||.|:. |.||.  ||::|
Mouse   195 FMGKTWTE---LLKHMR-EAHKEDITCNVCQRMFKRRDYLKQHMKTHAPERDVYRCPRQGCGRTY 255

  Fly   489 SQQAYLNKHIQA-HQMASAASASTSPGLLVAKQPHETLVC--IVCGSLHADATALASH--VHSQH 548
            :....|..||.: |:               .|:|   .||  ..||...|...:|..|  ||.
Mouse   256 TTVFNLQSHILSFHE---------------EKRP---FVCEHAGCGKTFAMKQSLMRHSVVHD-- 300

  Fly   549 AALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYVERVQCVLQQMNHQQQHQQHQQQPPQQQQQHP 613
                                ||.|....:.:|..||.....:...:         .||:::
Mouse   301 --------------------PDKKRMKLKVRAPRERRSLASRLSGY---------FPPKRK---- 332

  Fly   614 QQQQQQHLQQQPHQMQLPQQPKLPAMDSTGEDEEEPDEAEEPP 656
                              |:|.....:::.|....| ||:.||
Mouse   333 ------------------QEPDYSLPNASAESSSSP-EAQLPP 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	45/168 (27%)
		C2H2 Zn finger	256..276	CDD:275368	7/21 (33%)
		zf-H2C2_2	268..293	CDD:290200	9/26 (35%)
		C2H2 Zn finger	284..304	CDD:275368	6/21 (29%)
		zf-H2C2_2	296..321	CDD:290200	11/26 (42%)
		zf-C2H2_2	312..>387	CDD:289522	14/78 (18%)
		C2H2 Zn finger	312..332	CDD:275368	6/21 (29%)
		C2H2 Zn finger	340..360	CDD:275368	0/19 (0%)
		C2H2 Zn finger	369..389	CDD:275368	6/21 (29%)
		C2H2 Zn finger	397..417	CDD:275368	7/21 (33%)
		zf-H2C2_2	409..434	CDD:290200	8/27 (30%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	7/24 (29%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	13/27 (48%)
		C2H2 Zn finger	481..501	CDD:275368	8/22 (36%)
Gtf3a	NP_079928.2	zinc finger	40..62		7/21 (33%)
		C2H2 Zn finger	43..62	CDD:275368	6/18 (33%)
		COG5048	<62..185	CDD:227381	39/149 (26%)
		zinc finger	70..92		6/21 (29%)
		C2H2 Zn finger	70..92	CDD:275368	6/21 (29%)
		zinc finger	100..123		6/49 (12%)
		C2H2 Zn finger	100..123	CDD:275368	6/49 (12%)
		zinc finger	132..154		6/21 (29%)
		C2H2 Zn finger	135..154	CDD:275368	5/18 (28%)
		zinc finger	162..184		7/21 (33%)
		C2H2 Zn finger	162..184	CDD:275368	7/21 (33%)
		zinc finger	189..211		8/27 (30%)
		zinc finger	217..237		7/19 (37%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		zinc finger	246..269		8/22 (36%)
		C2H2 Zn finger	246..269	CDD:275368	8/22 (36%)
		zinc finger	277..299		6/21 (29%)
		C2H2 Zn finger	277..299	CDD:275368	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1498
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030