DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and znf366

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_698186.3	Gene:	znf366 / 569695	ZFINID:	ZDB-GENE-110408-46	Length:	559	Species:	Danio rerio

Alignment Length:	516	Identity:	139/516 - (26%)
Similarity:	215/516 - (41%)	Gaps:	98/516 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 SVTPLQQLLP-PAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALN--------GNQKCFQCTH 258
            |:.|...||| ..|.:||.....|.|.  |..||...|...::..::        |:||.::|..
Zfish    91 SLVPFPFLLPGSVPNLSPNPFYPSEPF--RVHRRPPDGPEKLNVHVDDSYYVDVGGDQKRWKCRM 153

  Fly   259 CEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSS 323
            ||.|:.:..:|..|:..|...||..||:|.|.|..:..|:||:..|.|.:|:||::|.|||||:|
Zfish   154 CEKSYTSKYNLITHILGHSGIKPHACSLCGKLFKQLSHLHTHMLTHQGTRPHKCQVCHKAFTQTS 218

  Fly   324 SLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRM 388
            .|..||..||..||:.|..|.:||...|.|..|:..|....|. :|.||..:|...|.|..|:..
Zfish   219 HLKRHMMQHSDVKPYSCSVCGRGFAYPSELRAHELKHERGQEN-VCVECGLDFPTLAQLKRHLTA 282

  Fly   389 HTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCS--------------------------- 426
            |...:.|.|:.|.::|:..|:|..||..|...:||.||
Zfish   283 HRGPVQYACSECGKSFQYPSQLQNHMMKHKDIRPFICSECGMEFVQSHHLKQHTLTHKGVKEHKC 347

  Fly   427 -LCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQ 490
             :|.|.||...::..|:.|||..:.:||:||.|.|.|..:|..||.:|:..|||.|.:|||.:::
Zfish   348 RICGREFTLLANMKRHVLIHTNIRAYQCELCYKSFVQKQTLKAHMIVHSDIKPYKCKLCGKEFNR 412

  Fly   491 QAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTM 555
            ...|..|:..|       :.:.|           ..|:.|.|.......|..|:..:|..:
Zfish   413 MHNLMGHMHLH-------SDSKP-----------FKCLYCASKFTLKGNLTRHMKIKHGIM---- 455

  Fly   556 KQSGMNTAPGGAIPDVKCSAEEQQAYVERVQCVLQQMNHQQQHQQHQQQPPQQQQQHPQQQQQQH 620
             ..|:         |.:....:.:..:.....:|.::.        |.:|....|::|
Zfish   456 -DQGL---------DARVCRRQGRLCLSGPLRILSRIG--------QDEPFDLSQKNP------- 495

  Fly   621 LQQQPHQMQLPQQPKLPAMDSTGEDEEEPDE----AEEPPDEEEEQDEPEEPAEVKTEVLA 677
                   ::|.|.........:...||:.|.    ::..||.|...:..::..|.||..||
Zfish   496 -------LRLSQSDGESVRGGSSSREEDEDSVYRMSQYSPDRENPAEARDQEDEKKTSHLA 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	59/158 (37%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	10/24 (42%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	31/74 (42%)
		C2H2 Zn finger	312..332	CDD:275368	11/19 (58%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	11/52 (21%)
		C2H2 Zn finger	425..445	CDD:275368	7/47 (15%)
		zf-H2C2_2	437..462	CDD:290200	10/24 (42%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
znf366	XP_698186.3	C2H2 Zn finger	151..171	CDD:275368	6/19 (32%)
		C2H2 Zn finger	179..199	CDD:275368	8/19 (42%)
		zf-C2H2	205..227	CDD:278523	12/21 (57%)
		C2H2 Zn finger	207..227	CDD:275368	11/19 (58%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..283	CDD:275368	7/19 (37%)
		COG5048	<288..431	CDD:227381	43/160 (27%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		C2H2 Zn finger	319..339	CDD:275368	2/19 (11%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	9/19 (47%)
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..450	CDD:275368	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1498
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030