DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and znf995

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_017209820.1	Gene:	znf995 / 563697	ZFINID:	ZDB-GENE-080215-13	Length:	358	Species:	Danio rerio

Alignment Length:	353	Identity:	119/353 - (33%)
Similarity:	175/353 - (49%)	Gaps:	52/353 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 FQLQMTDPRESTSIFMV---------------------QPTVSVTPLQQLLPPAPTVSPGLGLQS 225
            |.::..|.:|.|.:.::                     :||::          ..|:|.|...:|
Zfish    17 FTVKQEDLQEQTDLMLLKEKTHQQNEMEEKQQDMTTDEKPTLT----------KKTLSRGRPRKS 71

  Fly   226 TPIKRRRGRRSNIGA----------PVMDPALNGN--QKCFQCTHCEASFPNAGDLSKHVRSHIT 278
            .|       |.|...          |.:|..:..:  :|.:.|..|..||.|..:|:.|:|.|..
Zfish    72 KP-------RCNFSCKQCGKSFSQKPKLDVHIRDHTREKAYTCKQCGKSFYNTRNLTVHMRIHTG 129

  Fly   279 NKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQC 343
            .:|:.|..|.|:|...|:|..|:|||:||:||.|:.|.|:|..:.:|.||||.|:..||:.|.||
Zfish   130 ERPYTCQQCGKSFHKTGNLTVHLRIHTGERPYTCQQCGKSFQTTGNLTVHMRIHTGEKPYSCPQC 194

  Fly   344 DKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASS 408
            .|.:...|:|.:|.:||.. ..||:|.:|.:.|..:..||.|||:||.|..|.|..|.::|...|
Zfish   195 GKSYSQNSNLEVHMRTHNG-GRTFVCTQCGKSFVKKQNLDLHMRIHTGEKPYTCTECGKSFPYKS 258

  Fly   409 ELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIH 473
            .|..||..|.|||||.|:.|.:|||.:.:|..||..|||...|.|.||.|..|...|:..|||.|
Zfish   259 TLKHHMIVHTGEKPFACAQCGKSFTCNANLRNHMNGHTGTIVFTCDLCGKSLTHKYSIKNHMKTH 323

  Fly   474 AGEKPYPCPICGKSYSQQAYLNKHIQAH 501
            :||: :.|..|||.:..:..|:.|::.|
Zfish   324 SGER-FICIECGKGFKHKRSLSNHMELH 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	64/158 (41%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..293	CDD:290200	9/24 (38%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		zf-C2H2_2	312..>387	CDD:289522	29/74 (39%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	13/24 (54%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	11/24 (46%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
znf995	XP_017209820.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910