DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and MYNN

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	550	Identity:	148/550 - (26%)
Similarity:	217/550 - (39%)	Gaps:	172/550 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EDYSWIFEPVCELAEDGSDSSDGSASSGS-------------------DSSSSSDDDDDDDDDDS 135
            ||:::|..|         .|::.|:.:|:                   .|..|:|....:....:
Human   116 EDFAFIANP---------SSTEISSITGNIELNQQTCLLTLRDYNNREKSEVSTDLIQANPKQGA 171

  Fly   136 SSSSSSSSNSSSSSSSVPTTSNSNTQQ------SQESVQ----------PLHGLVAGPGYNEFQL 184
            .:..||.:.....:.:.|.|..:.|.|      ...||:          |:...||....|. :|
Human   172 LAKKSSQTKKKKKAFNSPKTGQNKTVQYPSDILENASVELFLDANKLPTPVVEQVAQINDNS-EL 235

  Fly   185 QMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNG 249
            ::|...|:|           .|.|.:            :.:..:||:||:
Human   236 ELTSVVENT-----------FPAQDI------------VHTVTVKRKRGK--------------- 262

  Fly   250 NQKCFQCTHCEASFPNAGDLSKHVRSHITN--KPFQ------------------CSICQKTFTHI 294
                        |.||.. |.:|..|:|.:  .|::                  |:.|.|.|:..
Human   263 ------------SQPNCA-LKEHSMSNIASVKSPYEAENSGEELDQRYSKAKPMCNTCGKVFSEA 314

  Fly   295 GSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKT 359
            .||..|:|||.|.|||.|.||.|||||.:.|..|:|:|:..||::|..|||||.....|:.|.:.
Human   315 SSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRM 379

  Fly   360 HIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFT 424
            |                            |.:|..|:|.:|...|..||.|..|.:.|.||||:.
Human   380 H----------------------------HGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYV 416

  Fly   425 CSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYS 489
            |..|.:.|.|:.:|..|:|.||||||:.|..|.|.|..:|||..|.:.|.|||||.|.|||||:.
Human   417 CDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFI 481

  Fly   490 QQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASH---VHSQHAAL 551
            ....||||.::|               ..::|   .:|.:||:.:.|...|..|   |||.....
Human   482 SSGELNKHFRSH---------------TGERP---FICELCGNSYTDIKNLKKHKTKVHSGADKT 528

  Fly   552 LDT-------MKQSGMNTAPGGAIPDVKCS 574
            ||:       .:|..:..:|.....|||.|
Human   529 LDSSAEDHTLSEQDSIQKSPLSETMDVKPS 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	54/178 (30%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		zf-H2C2_2	268..293	CDD:290200	9/44 (20%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	16/24 (67%)
		zf-C2H2_2	312..>387	CDD:289522	23/74 (31%)
		C2H2 Zn finger	312..332	CDD:275368	11/19 (58%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	0/19 (0%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	13/24 (54%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	15/24 (63%)
		C2H2 Zn finger	481..501	CDD:275368	10/19 (53%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197		4/27 (15%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		2/15 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		3/4 (75%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-C2H2	304..324	CDD:306579	8/19 (42%)
		zf-H2C2_2	316..341	CDD:316026	16/24 (67%)
		C2H2 Zn finger	332..352	CDD:275368	11/19 (58%)
		zf-H2C2_2	345..369	CDD:316026	12/23 (52%)
		SFP1	<354..438	CDD:227516	33/111 (30%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..437	CDD:275368	7/19 (37%)
		zf-H2C2_2	430..453	CDD:316026	12/22 (55%)
		SFP1	<439..522	CDD:227516	36/100 (36%)
		C2H2 Zn finger	445..465	CDD:275368	8/19 (42%)
		C2H2 Zn finger	473..493	CDD:275368	10/19 (53%)
		C2H2 Zn finger	501..522	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556		8/34 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910