DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and zbtb24

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001018866.2	Gene:	zbtb24 / 553955	ZFINID:	ZDB-GENE-081022-123	Length:	678	Species:	Danio rerio

Alignment Length:	617	Identity:	163/617 - (26%)
Similarity:	245/617 - (39%)	Gaps:	158/617 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 DSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPL-----------------HGLV----AGP 177
            |..::::.||......|:|.....|:::|..|..:.|                 |..|    ..|
Zfish    85 DGMTANTFSSVLEFMYSAVVLVDESSSEQLMEMARFLVIPDLIKAHEDLQAVDEHMQVKRKRGRP 149

  Fly   178 GYNEFQLQMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTP--IKRRRGRRSNIGA 240
            ..|:...|..:|.   |....|.:..:..:.:  .||...:.|...:..|  .:||.|:| .|..
Zfish   150 KKNQDLSQKENPE---SELQAQSSSEIQEVNE--EPASPATDGSDGEFNPREERRREGKR-KIKQ 208

  Fly   241 PV------MDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNT 299
            |:      ||..:.|.:            |.    .:..|....:...:|..|.|.|.....|..
Zfish   209 PIRLKGFRMDDLMEGKE------------PG----KRGRRRKYPDTEARCEECGKVFKSHLFLKI 257

  Fly   300 HIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPT 364
            |.|.|:||||::|.:|.|.|||..:|:||.|.|:..||:.|..|.|......|||.|...| ...
Zfish   258 HQRTHTGEKPFRCSVCGKEFTQKHTLLVHQRMHTGEKPYICTVCSKALSTKHSLLEHMNLH-TEN 321

  Fly   365 ETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCD 429
            :.|.|.||.:.|..:..|..|.|:||.:.:.:||.|...|..:::|.:|::.|.|||||||.:|.
Zfish   322 KLFTCEECGKSFSQQRQLKSHNRVHTGKGLPECAECHHKFMDAAQLKKHLRTHTGEKPFTCEICG 386

  Fly   430 RSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYL 494
            :.||...:|..|:|||.||||:.||:|||.|:..|:...|...|.|:|.:.|.||..|::::..|
Zfish   387 KCFTAKSTLQTHIRIHRGEKPYVCKVCDKTFSDPSARRRHEVSHTGKKTFSCSICKVSFARKDNL 451

  Fly   495 NKHIQAHQMAS--AASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQ 557
            ..||:.|...:  |.:.||.      |.||
Zfish   452 KAHIKTHNKENPPAQAESTD------KPPH----------------------------------- 475

  Fly   558 SGMNTAPGGAIPDVKCSAEEQQAYVERVQCVLQQMNHQQQHQQHQQQPPQQQQQHPQQQQQQHLQ 622
                            ||.|||                   ||.|:|..||||....::....||
Zfish   476 ----------------SAPEQQ-------------------QQQQEQEQQQQQTSGDKELHSILQ 505

  Fly   623 QQPHQMQLPQQPKLPAMDSTGE----DEEEPDEAEEPPDEEEE-----------QD----EPEEP 668
            .||.|:....:.::..: .|||    |:|:........|.|:.           |:    .|:..
Zfish   506 LQPFQLPAHGEQEIQLL-VTGENLSLDQEQSISIITSEDTEQSLALLTQPSGHVQNLAVVTPDGN 569

  Fly   669 AEVKT-EVLAAEDALTNPGYP----ILGLQEE 695
            |:::| .||..|   .|.|.|    ::.|.:|
Zfish   570 AQIQTISVLGGE---VNGGDPEQMHVITLSKE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	50/158 (32%)
		C2H2 Zn finger	256..276	CDD:275368	2/19 (11%)
		zf-H2C2_2	268..293	CDD:290200	5/24 (21%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	28/74 (38%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:290200	12/24 (50%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	15/24 (63%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	8/24 (33%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
zbtb24	NP_001018866.2	BTB	32..129	CDD:279045	9/43 (21%)
		BTB	43..129	CDD:197585	9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..211		18/77 (23%)
		C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		zf-H2C2_2	255..279	CDD:290200	12/23 (52%)
		COG5048	<266..456	CDD:227381	76/190 (40%)
		C2H2 Zn finger	270..290	CDD:275368	10/19 (53%)
		zf-H2C2_2	283..307	CDD:290200	10/23 (43%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		zf-H2C2_2	310..335	CDD:290200	10/25 (40%)
		zf-C2H2	324..346	CDD:278523	8/21 (38%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		zf-H2C2_2	367..390	CDD:290200	11/22 (50%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..418	CDD:290200	14/22 (64%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		zf-C2H2	436..458	CDD:278523	7/21 (33%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910