DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and znf971

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001013364.2	Gene:	znf971 / 503768	ZFINID:	ZDB-GENE-050306-52	Length:	406	Species:	Danio rerio

Alignment Length:	415	Identity:	126/415 - (30%)
Similarity:	172/415 - (41%)	Gaps:	80/415 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 FQLQMTDPRESTSIFMV------QPTVSVTPLQQLLPPAP--------------TVSPGLGLQST 226
            |.|:..||..:...|.|      |.|..:.|.|:...|..              |....|....|
Zfish    17 FTLKQEDPERTEETFRVKHEDPEQLTELIEPKQETEVPNKLEENDQYTSHLDFNTEEQSLSSSET 81

  Fly   227 -PIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKT 290
             ....::..:.|.||           ..|.|..|..||..:|.|..|:|.|...||:.|..|.||
Zfish    82 EKTSSQKRAQKNKGA-----------NSFTCQECGRSFSQSGTLKVHMRIHTGEKPYSCQQCGKT 135

  Fly   291 FTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLL 355
            |....:||.|:|.|:|.|||.|:.|.|:|:...|..:|||.|:..||:.|.||:|.|...|.|.|
Zfish   136 FRQSTTLNVHMRTHTGGKPYSCQQCGKSFSHRLSFTMHMRVHTGEKPYPCSQCEKSFNRNSDLQL 200

  Fly   356 HQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGE 420
            |.:.|.. .:.|.|.:|.:.|..:..|.:||..||||.::.|..|...|........|:..|..|
Zfish   201 HMRVHTG-EKPFTCQQCGKGFTRKGTLKDHMTTHTQEKLFTCKTCGITFTQKEIFKIHIVIHNSE 264

  Fly   421 KPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPY------ 479
            |||||:.|.:||.|.....:|.|.|:.||.|.|..|.|.|.|......||:.|.||:.|
Zfish   265 KPFTCNQCGKSFDQEEKFKLHKRFHSAEKHFPCSHCGKTFRQKQHFEDHMRTHTGEEVYACPHCE 329

  Fly   480 -----------------------PCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQP 521
                                   ||..||||:||::.||:|::.|               ..::|
Zfish   330 RSFSFKYRLDDHIRIHNREKREFPCDQCGKSFSQKSELNRHMRVH---------------TGEKP 379

  Fly   522 HETLVCIVCGSLHADATALASHVHS 546
            ..   |..||......:.|..|::|
Zfish   380 FS---CGHCGKSFKHNSGLKYHMNS 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	61/158 (39%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..293	CDD:290200	11/24 (46%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		zf-C2H2_2	312..>387	CDD:289522	27/74 (36%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	4/19 (21%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	10/24 (42%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	12/53 (23%)
		C2H2 Zn finger	481..501	CDD:275368	10/19 (53%)
znf971	NP_001013364.2	COG5048	97..>402	CDD:227381	109/324 (34%)
		C2H2 Zn finger	101..121	CDD:275368	8/19 (42%)
		zf-H2C2_2	114..138	CDD:290200	11/23 (48%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		C2H2 Zn finger	157..177	CDD:275368	8/19 (42%)
		zf-H2C2_2	169..194	CDD:290200	12/24 (50%)
		C2H2 Zn finger	185..205	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..222	CDD:290200	8/25 (32%)
		C2H2 Zn finger	213..233	CDD:275368	6/19 (32%)
		C2H2 Zn finger	241..261	CDD:275368	4/19 (21%)
		C2H2 Zn finger	269..289	CDD:275368	7/19 (37%)
		C2H2 Zn finger	297..317	CDD:275368	7/19 (37%)
		C2H2 Zn finger	325..345	CDD:275368	0/19 (0%)
		zf-C2H2	352..374	CDD:278523	11/21 (52%)
		C2H2 Zn finger	354..374	CDD:275368	10/19 (53%)
		zf-H2C2_2	366..391	CDD:290200	8/42 (19%)
		C2H2 Zn finger	382..402	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930