Protein Alignment CG12299 and ZNF699

DIOPT Version :10

• Sequence 1: NP_609448.1
• Gene: CG12299 / 34483
• FlyBaseID: FBgn0032295
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_940937.1
• Gene: ZNF699 / 374879
• HGNCID: 24750
• Length: 642
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 147/527 - (27%)
• Similarity: 230/527 - (43%)
• Gaps: 100/527 - (18%)

  Fly    68 NTLHPHEPGNGQQEQESPGDESEDYS-------WIFEPVCELAEDGSDSSDGSASSGSDSSSSSD 125
            ::||        :.|||.|.:.::.|       .:.|.:.|..|   ::.||...|...:..|..
Human   134 SSLH--------ENQESCGIDYQNKSHERHLRNHMVENIYECYE---ENQDGQTFSQVPNLDSLK 187

  Fly   126 DDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTDPR 190
            .:.:....:......:..:.||..|.:.:.:.|...|.:|..:..|.|..      |:..|..|.
Human   188 RNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLAC------FKKHMKTPT 246

  Fly   191 ES--------------TSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAP 241
            |.              :|.|.....:.:.....   .......|....|:..:.:|
Human   247 EEKPYECKECTKAFSCSSFFRAHMKIHIGKTNY---ECKECGKGFSCSSSLTEHKR--------- 299

  Fly   242 VMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSG 306
                 ::...|.::|..|..:|..:..||||.|.|..:||::|..|.|.|:....|..|||||:|
Human   300 -----IHSGDKPYECKECGKAFSCSSSLSKHKRIHSGDKPYECKECGKAFSSSSHLIIHIRIHTG 359

  Fly   307 EKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIA--------- 362
            ||||:|:.|.|||::||.|.||.|:|:..||::|.:|.|.:...|||.:|.:.|..
Human   360 EKPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKECGKAYNCPSSLSIHMRKHTGEKPYECLEC 424

  Fly   363 ------PT------------ETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSE 409
                  ||            :.:.|.||.:.|...:....|:|.||.::.|:|..|.:.|..||.
Human   425 GKAFYLPTSLNTHVKNQSREKPYECKECGKAFSCPSSFRAHVRDHTGKIQYECKECGKTFSRSSS 489

  Fly   410 LVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHA 474
            |.:|::.|.||||:.|..|.::|..|..|.:|:|.||||||::||.|.|.|...|:|.:||:.|.
Human   490 LTEHLRTHSGEKPYECKECGKAFISSSHLTVHIRTHTGEKPYECKKCGKAFIYPSALRIHMRTHT 554

  Fly   475 GEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATA 539
            |||||.|..|||::...:||..|.:.|               ..::|.|   |:.||...:..::
Human   555 GEKPYECKECGKAFRHSSYLTVHARMH---------------TGEKPFE---CLECGKAFSCPSS 601

  Fly   540 LASHVHS 546
            ...||.|
Human   602 FRRHVRS 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	245..>501	CDD:227381	107/282 (38%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:463886	16/24 (67%)
		C2H2 Zn finger	312..332	CDD:275368	11/19 (58%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:463886	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:463886	14/24 (58%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
ZNF699	NP_940937.1	KRAB	19..79	CDD:214630
		COG5048	<118..326	CDD:227381	38/225 (17%)
		C2H2 Zn finger	143..159	CDD:275368	2/15 (13%)
		C2H2 Zn finger	167..189	CDD:275368	5/24 (21%)
		C2H2 Zn finger	197..217	CDD:275368	3/19 (16%)
		zf-H2C2_2	209..232	CDD:463886	5/22 (23%)
		C2H2 Zn finger	225..245	CDD:275368	5/25 (20%)
		C2H2 Zn finger	253..273	CDD:275368	2/19 (11%)
		COG5048	276..641	CDD:227381	119/368 (32%)
		C2H2 Zn finger	281..301	CDD:275368	3/33 (9%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	11/19 (58%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..439	CDD:275368	2/17 (12%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	533..553	CDD:275368	9/19 (47%)
		C2H2 Zn finger	561..581	CDD:275368	7/19 (37%)
		C2H2 Zn finger	589..609	CDD:275368	6/20 (30%)
		C2H2 Zn finger	617..637	CDD:275368