DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zfp358

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001101798.1	Gene:	Zfp358 / 360754	RGDID:	1310416	Length:	652	Species:	Rattus norvegicus

Alignment Length:	650	Identity:	187/650 - (28%)
Similarity:	279/650 - (42%)	Gaps:	104/650 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 EPVCELAEDGSDSSD-------GSAS----------SGSDSSSSSDDDDDDDDDDSSSSSSSSSN 144
            :|.|..|..|..:||       ||.|          .|..|......|...|.:|...|..:...
  Rat    62 QPECSQAGQGRGASDPVPESARGSTSRMRRSVLVRNPGHKSLRPLYGDLPSDPEDLDPSPKAPDR 126

  Fly   145 SSSSSSSVPTTSNSNTQQSQESVQ-PLHGLVAGP----GYNEFQLQMTDPRESTSIFMVQPTVSV 204
            .|.|....|...|:.::....|:: |.......|    |..:...:..||  ::|.|.:.|.| :
  Rat   127 ISESPEPEPEDLNTVSEDGDASLEDPEPEAEEAPPSMLGKPDLDSRDLDP--TSSSFDLDPDV-I 188

  Fly   205 TPLQQLLPPA-PTVSPGL--------GLQSTPIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCE 260
            .|:..:|.|: .|:||..        .|.:||..........:.||...|      :.|.|..|.
  Rat   189 GPVPLVLDPSDDTLSPAAPHVDSLPSSLTATPEILATSSAVVLPAPASPP------RPFSCPDCG 247

  Fly   261 ASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSL 325
            .:|..:..||:|.|:|...||::|..|.|:|:|..:|..|..||:|.:||:|..|.|||...|:|
  Rat   248 RAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRSTL 312

  Fly   326 MVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHT 390
            :.|..|||..|||.|..|.|.|.:.|.|..|.:||..| ....||.|.:.|...:.|.:|:|.||
  Rat   313 LKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGP-RPHKCPVCAKGFGQGSALLKHLRTHT 376

  Fly   391 QELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKL 455
            .|..|.|..|.:||..||.|:||.:.|..|:|:.|..|.::|.||.:|..|:||||||:|:.|..
  Rat   377 GERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFGQSSNLQHHLRIHTGERPYACPH 441

  Fly   456 CDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTS-------- 512
            |.|.|.|:|:|..|:.:|:||:||.|.:|||::.|.:.|.||.:.|:.|:||:|:.:
  Rat   442 CSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAGLGL 506

  Fly   513 -PGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIPDVKCSAE 576
             |||..........:..    |..||.::..               ||:..: .||.| .:.||.
  Rat   507 GPGLSPVSMMRPGQISF----LGPDAVSVLG---------------SGLGLS-SGASP-ARSSAP 550

  Fly   577 EQQAYVERVQCVLQQMNHQQQHQQHQQQPPQQQQQHPQQQQQQHLQQQPHQMQLPQQPKLPAMDS 641
            ..         ||..:                  |:|..|........| .:.|...|| |.:|:
  Rat   551 TS---------VLGSL------------------QNPLLQTHSGSVSSP-DLVLSSDPK-PGLDA 586

  Fly   642 TGEDEEEPDEAEEPPDEEEEQDEPEEPAEVKTEVLAAEDALTNPGYPI----LGLQEEQILLDSD 702
            ..:....||:..:|....:....|:...:.:|:..:......:|..|.    ..::||..||..|
  Rat   587 DPDVVPSPDQELDPNPNPDLVPNPDSRPKSQTDPYSPTHDSPSPALPAGESPKWVKEEGALLGPD 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	65/158 (41%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	11/24 (46%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	30/74 (41%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		zf-H2C2_2	409..434	CDD:290200	9/24 (38%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	13/24 (54%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
Zfp358	NP_001101798.1	COG5048	<236..429	CDD:227381	78/199 (39%)
		zf-C2H2	241..263	CDD:278523	8/21 (38%)
		C2H2 Zn finger	243..263	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..280	CDD:290200	11/23 (48%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		zf-H2C2_2	284..306	CDD:290200	10/21 (48%)
		C2H2 Zn finger	299..319	CDD:275368	8/19 (42%)
		zf-H2C2_2	312..334	CDD:290200	11/21 (52%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-H2C2_2	340..362	CDD:290200	8/22 (36%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..390	CDD:290200	9/22 (41%)
		zf-C2H2_8	382..460	CDD:292531	34/77 (44%)
		C2H2 Zn finger	383..403	CDD:275368	9/19 (47%)
		zf-H2C2_2	395..418	CDD:290200	8/22 (36%)
		C2H2 Zn finger	411..431	CDD:275368	8/19 (42%)
		zf-H2C2_2	423..446	CDD:290200	12/22 (55%)
		C2H2 Zn finger	439..459	CDD:275368	8/19 (42%)
		zf-H2C2_2	451..474	CDD:290200	11/22 (50%)
		zf-C2H2	465..487	CDD:278523	9/21 (43%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3218
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050