DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12299 and ZNF850

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	444	Identity:	139/444 - (31%)
Similarity:	199/444 - (44%)	Gaps:	91/444 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 STPIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQK 289
            ||.|:.:|              ::..:|.:.|..|..||.:...|.:|.|.|...||:.|..|.|
Human   434 STLIQHQR--------------IHTGEKPYDCKECGKSFASGSALLQHQRIHTGEKPYCCKECGK 484

  Fly   290 TFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLL 354
            :||...:.|.|.|||:|||||.|:.|.|:|...|:|:.|.|.|:..||:.|.:|.|.|...|.|:
Human   485 SFTFRSTRNRHQRIHTGEKPYNCKECGKSFASGSALLQHQRIHTGEKPYHCKECGKSFTFRSGLI 549

  Fly   355 LHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMG 419
            .||..|.. .:.:.|.||.:.|.:.:.|.:|.|:||.|..|.|..|.::|...|.|:||.:.|.|
Human   550 GHQAVHTG-EKPYDCKECGKSFTSRSALIQHQRIHTGEKPYHCKECGKSFTVGSTLLQHQQIHTG 613

  Fly   420 EKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPIC 484
            |||:.|..|.::|.....|..|.:|||||||:||:.|.|.|...|.|:.|.:||.|||||.||.|
Human   614 EKPYDCKECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSGLTQHHRIHTGEKPYECPDC 678

  Fly   485 GKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHA 549
            ||::.|:.|||:|.:.|               ..::|:|   |..||......:.|..| ...|.
Human   679 GKAFRQRTYLNQHRRIH---------------TGEKPYE---CKECGKSFTFCSGLIQH-QQNHT 724

  Fly   550 ALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYVERVQCVLQQMNHQQ--QHQQ-HQQQPPQQQQQ 611
                                       :::.| :..:|.....:|..  |||| |..:.|...::
Human   725 ---------------------------DEKPY-DGKECGKSFTSHSTLIQHQQIHTGEKPYDCKE 761

  Fly   612 -------HPQ--QQQQQHLQQQ------------PHQMQLPQQPKLPAMDSTGE 644
                   |..  |.||.|..::            .|...:..||.     .|||
Human   762 CGKSFTSHSTLIQHQQIHTGEKLYDCKECGKSFTSHSTLIQHQPL-----HTGE 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	61/158 (39%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	10/24 (42%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	14/24 (58%)
		zf-C2H2_2	312..>387	CDD:289522	26/74 (35%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		zf-H2C2_2	437..462	CDD:290200	14/24 (58%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	14/24 (58%)
		C2H2 Zn finger	481..501	CDD:275368	10/19 (53%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	90/239 (38%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368	4/22 (18%)
		zf-H2C2_2	436..460	CDD:290200	7/37 (19%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	463..487	CDD:290200	9/23 (39%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		zf-H2C2_2	493..516	CDD:290200	14/22 (64%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		zf-H2C2_2	519..543	CDD:290200	9/23 (39%)
		COG5048	531..947	CDD:227381	100/333 (30%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
		zf-H2C2_2	575..599	CDD:290200	9/23 (39%)
		C2H2 Zn finger	591..611	CDD:275368	7/19 (37%)
		C2H2 Zn finger	619..639	CDD:275368	5/19 (26%)
		zf-H2C2_2	632..656	CDD:290200	14/23 (61%)
		C2H2 Zn finger	647..667	CDD:275368	7/19 (37%)
		zf-H2C2_2	660..684	CDD:290200	14/23 (61%)
		C2H2 Zn finger	675..695	CDD:275368	10/19 (53%)
		zf-H2C2_2	687..711	CDD:290200	10/41 (24%)
		C2H2 Zn finger	703..723	CDD:275368	5/20 (25%)
		C2H2 Zn finger	732..751	CDD:275368	6/18 (33%)
		C2H2 Zn finger	759..779	CDD:275368	4/19 (21%)
		C2H2 Zn finger	787..807	CDD:275368	3/24 (13%)
		C2H2 Zn finger	815..835	CDD:275368
		C2H2 Zn finger	843..863	CDD:275368
		zf-H2C2_2	856..879	CDD:290200
		C2H2 Zn finger	871..891	CDD:275368
		C2H2 Zn finger	899..919	CDD:275368
		zf-H2C2_2	912..936	CDD:290200
		C2H2 Zn finger	927..947	CDD:275368
		C2H2 Zn finger	955..975	CDD:275368
		zf-H2C2_2	967..992	CDD:290200
		C2H2 Zn finger	983..1003	CDD:275368
		zf-H2C2_2	995..1020	CDD:290200
		C2H2 Zn finger	1011..1031	CDD:275368
		zf-H2C2_2	1024..1046	CDD:290200
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1498
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940