DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zbtb25

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_955790.1	Gene:	Zbtb25 / 314245	RGDID:	735076	Length:	438	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	85/400 - (21%)
Similarity:	134/400 - (33%)	Gaps:	119/400 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 TPLQQLLPPAPTVSPGL-GL-----QSTPIKRRRGRRSNIGAPVMD--PALNGNQKCFQCTH--- 258
            |.:.|:..|....:..| |:     |.|.:|:        |..:.|  |:.:||:......|
  Rat   112 TEMNQVFSPETVQTSNLYGIQISTTQKTAVKQ--------GLEIKDTPPSSSGNRAAAPGDHPQL 168

  Fly   259 --------------CEASFPNAGDLSKHVRSHITNKPFQC---SICQKTFTHIGSLNTHIRIHSG 306
                          .:.:.|.|..|.:|.:..:|.|..:|   |:..::             ||.
  Rat   169 QLSLAIGLDDGGAEQQRAHPAAQALEEHQKPPVTIKQERCDPESVISQS-------------HSS 220

  Fly   307 EKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPE 371
            .   ..|:...:||::|.           |.|.|..|.:.|.:.|:|..|..||::.:..|..|.
  Rat   221 S---SSEVTGSSFTENSV-----------KVHLCHYCGERFESRSNLRQHLHTHVSGSLPFGVPA 271

  Fly   372 CEREFKAEALLDEHMRMHTQELVYQCAICRE--AFRASSELVQ-HMKNHMGEKP------FTCSL 427
            ...|  :..|.:.|....:.|.:.    ||.  :|.|..:..| ....|.|..|      ...|:
  Rat   272 SILE--SNDLGEVHPLSGSSEALE----CRRLGSFLAEEDGQQPRPPEHSGRGPSEPLQISQVSV 330

  Fly   428 CDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPY---PCPICGKSYS 489
            ..:. |:...||.:... :.::...|.:|...|.:.|.|..||..|.| |.|   .|...|.|.:
  Rat   331 ISKD-TEPVELNCNFSF-SRKRKISCTICGHKFLRKSQLLEHMYTHKG-KSYRYNRCQRFGNSLA 392

  Fly   490 Q--QAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALL 552
            |  |.|.:.........|..|           |.|..|.|                      ||.
  Rat   393 QRFQQYCDSWPDVSLKTSRLS-----------QEHLDLPC----------------------ALE 424

  Fly   553 DTMKQSGMNT 562
            ..|.|:|::|
  Rat   425 SEMTQAGVDT 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	36/181 (20%)
		C2H2 Zn finger	256..276	CDD:275368	5/36 (14%)
		zf-H2C2_2	268..293	CDD:290200	6/27 (22%)
		C2H2 Zn finger	284..304	CDD:275368	2/22 (9%)
		zf-H2C2_2	296..321	CDD:290200	4/24 (17%)
		zf-C2H2_2	312..>387	CDD:289522	19/74 (26%)
		C2H2 Zn finger	312..332	CDD:275368	4/19 (21%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	4/19 (21%)
		C2H2 Zn finger	397..417	CDD:275368	5/22 (23%)
		zf-H2C2_2	409..434	CDD:290200	5/31 (16%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		zf-H2C2_2	437..462	CDD:290200	5/24 (21%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	10/27 (37%)
		C2H2 Zn finger	481..501	CDD:275368	6/21 (29%)
Zbtb25	NP_955790.1	BTB_POZ_ZBTB25_ZNF46_KUP	3..130	CDD:349522	4/17 (24%)
		C2H2 Zn finger	238..260	CDD:275369	7/21 (33%)
		zf-C2H2	240..260	CDD:395048	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000