DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zbtb17

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_038966007.1	Gene:	Zbtb17 / 313666	RGDID:	1307143	Length:	819	Species:	Rattus norvegicus

Alignment Length:	667	Identity:	167/667 - (25%)
Similarity:	258/667 - (38%)	Gaps:	183/667 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PILQQTHLLPQQAPNPPQ------------QQPQQPQP----PDLTFHCMCCAEFFVHPLALYQH 66
            |.:::|||...|:|||..            ..|::|.|    ||.| ..|..||......:..|.
  Rat   182 PAMEETHLTSAQSPNPASHPSSGAEQTEKADAPREPPPVELKPDPT-SSMAAAEAEALSESSEQE 245

  Fly    67 MNTLHPHEPGNGQQEQESPGDESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDDDDD-- 129
            |. :.|...|...||:|.||..:            :.|:|....:|.....::.|:.:|...:
  Rat   246 ME-VEPASKGEEGQEEEGPGPAT------------VKEEGVHLENGEPPEENEESAGTDSGHELG 297

  Fly   130 -DDDDDSSSSSSSSSNSSSSSSSVPTTSN-----SNTQQSQESVQPLHGLVAGPGYNEFQLQMTD 188
             :..:..|.:....:.|.:..|.:....:     ::|...:..:: :|     .|...|..
  Rat   298 MEGQNLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIR-IH-----TGEKPFSC---- 352

  Fly   189 PRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNGNQKC 253
             ||.:..|                            |.|...:...:::  :|:         |.
  Rat   353 -RECSKAF----------------------------SDPAACKAHEKTH--SPL---------KP 377

  Fly   254 FQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKA 318
            :.|..|..|:.....|:.|.:.|.....::|..|.|.||..|:|..|..:|||:|||:|:.|.::
  Rat   378 YGCEECGKSYRLISLLNLHKKRHSGEARYRCGDCGKLFTTSGNLKRHQLVHSGQKPYQCDYCGRS 442

  Fly   319 FTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAP-------------------- 363
            |:..:|.|.|:.:|...|.|:|..|||.|....:|..|.|.|||.
  Rat   443 FSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKR 507

  Fly   364 -------TETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEK 421
                   .:.::|..|:|:|.....|..|:|:||.|...||.||.:||..:|.|:.|::.|.|||
  Rat   508 HLRIHSGEKPYVCTHCQRQFADPGALQRHVRIHTGEKPCQCVICGKAFTQASSLIAHVRQHTGEK 572

  Fly   422 PFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGK 486
            |:.|..|.:.|.||..|..|:|.|...:|.:|.:|.|.|.....||.|:.||.|||||.|..||:
  Rat   573 PYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGR 637

  Fly   487 SYSQQAYLNKHIQ-AHQ--------------------------MASAASASTS--------PGLL 516
            .:::...|..|:: .||                          :|:.|.|:|:        .|..
  Rat   638 GFNRVDNLRSHVKTVHQGKAGIKILEPEEGGEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAA 702

  Fly   517 VAKQPHETL----------------------VCIVCGSLHADATALASHV--HSQHAALL----- 552
            |.....|.|                      .|..||....||.:||.||  |:..|.::
  Rat   703 VTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDA 767

  Fly   553 DTMKQSGMNTAPGGAIP 569
            |..:|.|    ||||.|
  Rat   768 DFYQQYG----PGGAWP 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	58/185 (31%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		zf-H2C2_2	268..293	CDD:290200	7/24 (29%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	11/24 (46%)
		zf-C2H2_2	312..>387	CDD:289522	26/101 (26%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	8/19 (42%)
		zf-H2C2_2	409..434	CDD:290200	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	9/24 (38%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	5/20 (25%)
Zbtb17	XP_038966007.1	BTB_POZ_ZBTB17_MIZ1	2..113	CDD:349515
		COG5048	322..653	CDD:227381	104/380 (27%)
		C2H2 Zn finger	324..344	CDD:275368	1/20 (5%)
		C2H2 Zn finger	352..372	CDD:275368	5/52 (10%)
		C2H2 Zn finger	380..400	CDD:275368	5/19 (26%)
		C2H2 Zn finger	408..428	CDD:275368	8/19 (42%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		C2H2 Zn finger	492..512	CDD:275368	0/19 (0%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	8/19 (42%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		C2H2 Zn finger	632..651	CDD:275370	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910