DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12299 and Zfp18

DIOPT Version :9

Sequence 1:NP_609448.1 Gene:CG12299 / 34483 FlyBaseID:FBgn0032295 Length:736 Species:Drosophila melanogaster
Sequence 2:NP_001012008.1 Gene:Zfp18 / 303226 RGDID:1305130 Length:556 Species:Rattus norvegicus


Alignment Length:626 Identity:136/626 - (21%)
Similarity:219/626 - (34%) Gaps:202/626 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAVQLKQSYHHLPLTI---------TPILQQTHLL-PQ-----------QAPNPPQQQPQQPQPP 44
            |.|.|.|:...||...         :.::||..|. |:           |..:.||:..:|.:  
  Rat     1 MPVNLGQALGLLPFLAKAEDATFSGSDVIQQRELANPETARQLFRQFRYQVMSGPQETLRQLR-- 63

  Fly    45 DLTFHCMCCAEFF---VH------PLALYQHMNTLHPHE---------PGNGQQE----QESPGD 87
                  ..|.::.   ||      .:.:.:...|:.|.|         ||:|::.    :...||
  Rat    64 ------KLCFQWLRPEVHTKEQILEILMLEQFLTILPGEIQMWVRKQCPGSGEEAVTLVESLKGD 122

  Fly    88 ESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSV 152
            ..:.:.||...|  |.::.....:.||....|...                              
  Rat   123 PQKLWQWISIQV--LGQEIPFEKENSARCRGDKVE------------------------------ 155

  Fly   153 PTTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTV 217
            |......|.:......||....:.||    :|.....:|.:.:   :|.:::...|  ||..|  
  Rat   156 PALEAEPTVEVVPQDLPLQNTSSAPG----ELLSHGVKEESDL---EPELALAASQ--LPARP-- 209

  Fly   218 SPGLGLQSTPIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCEAS---------FPNAGDLSKHV 273
                       :.|..|...:|..:: |:|...    |..|.:::         ....|.:...|
  Rat   210 -----------EERPTRDQEVGTALL-PSLQEE----QWRHLDSTQKEQYWDLMLETYGKMVSGV 258

  Fly   274 RSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEK---------------------PYKCELCPK 317
            .....:||...::.:.....:|     :.:||.||                     .::.:.|..
  Rat   259 AGISNSKPDLTNMAEYGEELVG-----LHLHSAEKMARAPCKEDRQENDKENLNLENHRDQGCLD 318

  Fly   318 AFTQS---------------SSLMVHMRSHSVRK---------------PH---------QCVQC 343
            .|.|:               .|...|....||.:               ||         |.:|.
  Rat   319 VFDQAPGEAPPQTALSDFFGESEPHHFGGESVPEALENLQGEGTGAHLFPHERGSGKQLGQHIQS 383

  Fly   344 DKGFINYSSLLLHQKTHIA-------------PTETFICPECEREFKAEALLDEHMRMHTQELVY 395
            .... ..|:|.|.:|...:             ||    |.||.:.|...:.|..|.|.||.|..:
  Rat   384 SSSG-ELSALWLEEKREASQKGQARAPMAQKLPT----CRECGKTFYRNSQLVFHQRTHTGETYF 443

  Fly   396 QCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCF 460
            .|.||::||..||:.|:|.:.|.||||..|..|.:.|:....|..|.:|||||||::|.:|:|.|
  Rat   444 HCRICKKAFLRSSDFVKHQRTHTGEKPCKCDYCGKGFSDFSGLRHHEKIHTGEKPYKCPICEKSF 508

  Fly   461 TQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAH 501
            .|.|:.:.|.::|.|||||.|..|||.:|..:.|:||.::|
  Rat   509 IQRSNFNRHQRVHTGEKPYKCTHCGKRFSWSSSLDKHQRSH 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12299NP_609448.1 COG5048 <254..413 CDD:227381 46/240 (19%)
C2H2 Zn finger 256..276 CDD:275368 3/28 (11%)
zf-H2C2_2 268..293 CDD:290200 3/24 (13%)
C2H2 Zn finger 284..304 CDD:275368 1/19 (5%)
zf-H2C2_2 296..321 CDD:290200 6/45 (13%)
zf-C2H2_2 312..>387 CDD:289522 23/126 (18%)
C2H2 Zn finger 312..332 CDD:275368 5/34 (15%)
C2H2 Zn finger 340..360 CDD:275368 5/19 (26%)
C2H2 Zn finger 369..389 CDD:275368 7/19 (37%)
C2H2 Zn finger 397..417 CDD:275368 9/19 (47%)
zf-H2C2_2 409..434 CDD:290200 10/24 (42%)
C2H2 Zn finger 425..445 CDD:275368 5/19 (26%)
zf-H2C2_2 437..462 CDD:290200 13/24 (54%)
C2H2 Zn finger 453..473 CDD:275368 7/19 (37%)
zf-H2C2_2 465..490 CDD:290200 11/24 (46%)
C2H2 Zn finger 481..501 CDD:275368 8/19 (42%)
Zfp18NP_001012008.1 SCAN 37..144 CDD:128708 20/116 (17%)
SCAN 37..125 CDD:280241 16/95 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..195 6/32 (19%)
KRAB_A-box 226..256 CDD:143639 4/33 (12%)
C2H2 Zn finger 417..437 CDD:275368 7/19 (37%)
COG5048 <428..521 CDD:227381 39/92 (42%)
zf-H2C2_2 433..454 CDD:290200 10/20 (50%)
C2H2 Zn finger 445..465 CDD:275368 9/19 (47%)
zf-H2C2_2 457..481 CDD:290200 9/23 (39%)
C2H2 Zn finger 473..493 CDD:275368 5/19 (26%)
zf-H2C2_2 486..510 CDD:290200 13/23 (57%)
COG5048 497..>549 CDD:227381 23/51 (45%)
C2H2 Zn finger 501..521 CDD:275368 7/19 (37%)
zf-H2C2_2 513..537 CDD:290200 11/23 (48%)
zf-C2H2 527..549 CDD:278523 9/21 (43%)
C2H2 Zn finger 529..549 CDD:275368 8/19 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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