DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and ZNF473

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001006657.1	Gene:	ZNF473 / 25888	HGNCID:	23239	Length:	871	Species:	Homo sapiens

Alignment Length:	341	Identity:	119/341 - (34%)
Similarity:	176/341 - (51%)	Gaps:	51/341 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 IGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITN-KPFQCSICQKTFTHIGSLNTHI 301
            :...::|......:|||:|..||.:|..:..|::|.|.|... |||:|..|.|.|.....|..|.
Human   546 VSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQ 610

  Fly   302 RIHS-------GEK--------------------PYKCELCPKAFTQSSSLMVHMRSHSVRKPHQ 339
            ||||       ||:                    |:||..|.|.|:.|:.|..|...|:...|.:
Human   611 RIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFK 675

  Fly   340 CVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAF 404
            |.:||:.|...:.|:.|::|| |..:..:|.||.:.|:..:.|.:|.|:|:.|..|.|..|.:||
Human   676 CSKCDRVFTQRNYLVQHERTH-ARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAF 739

  Fly   405 RASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVH 469
            ..|:|||:|.:.|.||||:.|..|.::||||..|:||.|:||||||::|..|.|.|.|.::|:.|
Human   740 GLSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQH 804

  Fly   470 MKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLV-CIVCGSL 533
            .:||.|||||.|.:|||::...|:||:|::.|                   ..|||. |..|...
Human   805 QRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVH-------------------TQETLYQCQRCQKA 850

  Fly   534 HADATALASH--VHSQ 547
            ....::|:.|  ||::
Human   851 FRCHSSLSRHQRVHNK 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	62/186 (33%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	11/25 (44%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	14/51 (27%)
		zf-C2H2_2	312..>387	CDD:289522	24/74 (32%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		zf-H2C2_2	409..434	CDD:290200	12/24 (50%)
		C2H2 Zn finger	425..445	CDD:275368	10/19 (53%)
		zf-H2C2_2	437..462	CDD:290200	14/24 (58%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
ZNF473	NP_001006657.1	KRAB_A-box	6..45	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164
		COG5048	207..614	CDD:227381	23/67 (34%)
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368
		C2H2 Zn finger	267..286	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..318
		Interaction with SLBP/pre-mRNA complex	312..552		0/5 (0%)
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..453	CDD:275368
		COG5048	457..860	CDD:227381	116/333 (35%)
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..537	CDD:275368
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		C2H2 Zn finger	593..613	CDD:275368	7/19 (37%)
		C2H2 Zn finger	648..668	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..724	CDD:275368	7/19 (37%)
		C2H2 Zn finger	732..752	CDD:275368	9/19 (47%)
		C2H2 Zn finger	760..780	CDD:275368	10/19 (53%)
		C2H2 Zn finger	788..808	CDD:275368	7/19 (37%)
		C2H2 Zn finger	816..836	CDD:275368	8/19 (42%)
		C2H2 Zn finger	844..864	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910