DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zbtb38

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_036010907.1	Gene:	Zbtb38 / 245007	MGIID:	2442866	Length:	1243	Species:	Mus musculus

Alignment Length:	612	Identity:	131/612 - (21%)
Similarity:	204/612 - (33%)	Gaps:	190/612 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 NTL--HPHEPGNGQQEQESPGD----ESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDD 126
            |||  .|..|......|.:|..    .:|...|..:.|.....|..||::.|.||..::.|::..
Mouse   667 NTLPSSPAVPVETPSRQGAPTSARVKNAEGIKWRKQAVKTNLVDNFDSTEVSVSSTGNTVSATLQ 731

  Fly   127 DDDDDDDDSSSSSSSSSNSSSSSSSVPT---------------------TSNSNTQQSQESVQPL 170
            .:..........|..|::..|.|.|||:                     |::::...||..|.|.
Mouse   732 TEPACVSSVGKGSEHSASVISYSGSVPSVIVHSSQFSSVIKHSNTIASLTNSNHKSPSQPVVSPS 796

  Fly   171 ---------------------------------------------HGLVAGPGYNEFQLQMTDPR 190
                                                         ||..:|        :.|:..
Mouse   797 LIKDSKPETDKASKPASRPKSIKEKKKTAPSNRGEITEEAKYIADHGGSSG--------KTTNAE 853

  Fly   191 ESTSI--FMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKR---------RRGR---------- 234
            |::.|  ::.:|.:..|.....:.|...::..:|.::. :||         :|||
Mouse   854 ETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAI-VKRHILGSKLFYKRGRKPKYQMQEET 917

  Fly   235 --RSNIGAPVMDPALNGNQK---C-FQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTH 293
              |.|      ||...|:..   | .:|.....:|....|...      |:||:
Mouse   918 LPREN------DPETPGDSPLGLCQAECVEMSEAFDEVSDQDS------TDKPW----------- 959

  Fly   294 IGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQK 358
                    |.:...||.|          .|..:..||....||..:. :...|...|.:.|...:
Mouse   960 --------RPYYNYKPKK----------KSKQLRKMRKVKWRKERRS-RSPVGRCRYPAELDRAE 1005

  Fly   359 THIAPTETFICPECEREFK-----------------AEALLDEHMRMHTQELVYQCAICREAFRA 406
            ..:.|.:.|...|.|.|.|                 |.|..:.....|.....|.|.:|.:.|::
Mouse  1006 VKLPPDKAFEEEEEEEENKEMPKLQCELCDGCPDGAAGAGAEGKPHQHLTSKPYICELCAKQFQS 1070

  Fly   407 SSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMK 471
            ||.|..||:.|.||||:.|..|.|.|:..|:|..|.|||.|.|.|.|:.|:|.||...:|.:|.:
Mouse  1071 SSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETLKIHER 1135

  Fly   472 IHAGEKPYPCPICGKSY----SQQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIVCGS 532
            ||.|||.|.|..|.:.:    :::.:..:||:.|.....|                   |..|..
Mouse  1136 IHTGEKRYHCQFCFQGFLYLSTKRNHERRHIREHDGKGFA-------------------CFQCPK 1181

  Fly   533 LHADATALASHVHSQHAALLDTMKQSG 559
            :...|.||..|........|...:::|
Mouse  1182 ICKTAAALRMHQKKHLYKTLPKQEETG 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	34/175 (19%)
		C2H2 Zn finger	256..276	CDD:275368	3/19 (16%)
		zf-H2C2_2	268..293	CDD:290200	4/24 (17%)
		C2H2 Zn finger	284..304	CDD:275368	1/19 (5%)
		zf-H2C2_2	296..321	CDD:290200	4/24 (17%)
		zf-C2H2_2	312..>387	CDD:289522	16/91 (18%)
		C2H2 Zn finger	312..332	CDD:275368	3/19 (16%)
		C2H2 Zn finger	340..360	CDD:275368	3/19 (16%)
		C2H2 Zn finger	369..389	CDD:275368	6/36 (17%)
		C2H2 Zn finger	397..417	CDD:275368	8/19 (42%)
		zf-H2C2_2	409..434	CDD:290200	12/24 (50%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	12/24 (50%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	10/28 (36%)
		C2H2 Zn finger	481..501	CDD:275368	4/23 (17%)
Zbtb38	XP_036010907.1	BTB_POZ_ZBTB38_CIBZ	61..174	CDD:349532
		zf-C2H2_8	<386..446	CDD:406359
		C2H2 Zn finger	388..408	CDD:275368
		C2H2 Zn finger	417..436	CDD:275368
		C2H2 Zn finger	506..526	CDD:275368
		C2H2 Zn finger	534..554	CDD:275368
		C2H2 Zn finger	562..580	CDD:275368
		C2H2 Zn finger	1061..1081	CDD:275368	8/19 (42%)
		zf-H2C2_2	1074..1097	CDD:404364	11/22 (50%)
		zf-C2H2	1087..1109	CDD:395048	8/21 (38%)
		C2H2 Zn finger	1089..1109	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1117..1137	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1145..1165	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1176..1196	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000