DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zfp382

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001074476.1	Gene:	Zfp382 / 233060	MGIID:	3588204	Length:	579	Species:	Mus musculus

Alignment Length:	313	Identity:	112/313 - (35%)
Similarity:	162/313 - (51%)	Gaps:	36/313 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 QKCFQCTHCEASFPNAGDL-------SKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEK 308
            :||       :|:...|:|       ..|..|.:..:||||..|..:|.....|..|.|||:|||
Mouse   294 KKC-------SSYNKYGELLCRKSVFVMHPSSQMDERPFQCPYCGNSFRRKSYLIEHERIHTGEK 351

  Fly   309 PYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECE 373
            ||.|..|.:||.|.::|.:|.::|:..||:.||.|.|.|...::|..|.|.|.. .:.:.|.:|.
Mouse   352 PYICCQCGRAFRQKTALTLHEKTHTEGKPYLCVDCGKSFRQKATLTRHHKAHTG-EKAYECTQCG 415

  Fly   374 REFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSL 438
            ..|..::.|.:|.|.||.|..|||..|.:||...:.|..|.:.|.||||:.||.|.:||.|..:|
Mouse   416 SAFGKKSYLIDHQRTHTGEKPYQCTECGKAFIQKTTLTVHQRTHTGEKPYICSECGKSFCQKTTL 480

  Fly   439 NIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQM 503
            .:|.||||||||:.|..|.|.|.|.:.|:||.:||.|||...||.|||::|:::.|.:|.:.|
Mouse   481 TLHQRIHTGEKPYICSDCGKSFRQKAILTVHYRIHTGEKSNGCPQCGKAFSRKSNLIRHQKIH-- 543

  Fly   504 ASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMK 556
                         ..::|:|   |..||...:..:.|.:|   |.....:||:
Mouse   544 -------------TGEKPYE---CQECGKFFSCKSNLITH---QKTHKTETMR 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	56/165 (34%)
		C2H2 Zn finger	256..276	CDD:275368	4/26 (15%)
		zf-H2C2_2	268..293	CDD:290200	9/31 (29%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-H2C2_2	296..321	CDD:290200	14/24 (58%)
		zf-C2H2_2	312..>387	CDD:289522	24/74 (32%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:290200	12/24 (50%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		zf-H2C2_2	437..462	CDD:290200	14/24 (58%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
Zfp382	NP_001074476.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Mediates interaction with TRIM28. /evidence=ECO:0000250	12..135
		Represses transcription. /evidence=ECO:0000250	40..81
		KRAB	42..102	CDD:214630
		KRAB	42..81	CDD:279668
		Represses transcription. /evidence=ECO:0000250	105..240
		C2H2 Zn finger	303..319	CDD:275368	3/15 (20%)
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	325..579		104/275 (38%)
		zf-C2H2	325..347	CDD:278523	8/21 (38%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..364	CDD:290200	14/24 (58%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		C2H2 Zn finger	383..403	CDD:275368	8/19 (42%)
		COG5048	<411..562	CDD:227381	65/168 (39%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..448	CDD:290200	12/24 (50%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		zf-H2C2_2	452..474	CDD:290200	10/21 (48%)
		C2H2 Zn finger	467..487	CDD:275368	9/19 (47%)
		zf-H2C2_2	480..504	CDD:290200	14/23 (61%)
		C2H2 Zn finger	495..515	CDD:275368	8/19 (42%)
		C2H2 Zn finger	523..543	CDD:275368	8/19 (42%)
		zf-C2H2	523..543	CDD:278523	8/19 (42%)
		zf-H2C2_2	535..560	CDD:290200	8/42 (19%)
		C2H2 Zn finger	551..571	CDD:275368	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000