DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12299 and Zfp341

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_955008.2	Gene:	Zfp341 / 228807	MGIID:	2682937	Length:	846	Species:	Mus musculus

Alignment Length:	656	Identity:	146/656 - (22%)
Similarity:	206/656 - (31%)	Gaps:	272/656 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VQLKQSYHHLP--LTITPILQQTHLLPQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQ 65
            ||...:.|.:|  ||..|        |...|.||...|.||.||.
Mouse   162 VQNSLNMHPVPNYLTQPP--------PPPPPPPPLPPPPQPPPPP-------------------- 198

  Fly    66 HMNTLHPHEPGNGQQEQESPGDESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDDDDDD 130
             ..||.|
Mouse   199 -PQTLGP---------------------------------------------------------- 204

  Fly   131 DDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQ---LQMTDPRES 192
                       |..|:...:||....|        :..|:    ||.|..|.|   :|...|.|.
Mouse   205 -----------SGRSNPVGNSVVEVYN--------AAAPM----AGNGTVEIQALGMQPYPPLEV 246

  Fly   193 TSIFMVQPTVSVTPL-----QQLLPPAP---------TVSPGLGLQSTP-IKRRRGRRSNIGAPV 242
            .|..:..|.....|:     |:..|..|         |.|......|.| :|.||.:    ||..
Mouse   247 PSQCVEAPVYPTPPVYSPGKQEFKPKGPSSTAPMTNATGSTVATFDSPPTLKTRRAK----GASG 307

  Fly   243 MDPALNGNQKC--FQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIH- 304
            : |...|..|.  .:|::|:.||....||.:|:|||...|||||..|.:.|....::..|::.|
Mouse   308 L-PEAAGKPKAQKLKCSYCDKSFTKNFDLQQHIRSHTGEKPFQCIACGRAFAQKSNVKKHMQTHK 371

  Fly   305 ------------------------------------------------------SGEKP------ 309
                                                                  .|:||
Mouse   372 VWPPGRSGGTVSRNSVTVQVMALNPNRQEEEDTGLGQSLSSTTQPQALPTAGEDEGDKPEAKQVV 436

  Fly   310 -----YKCELCPKAFT---QSSSLMV---------------------------HMRSHSVRKPHQ 339
                 |.|:.||..|:   |..|.|:                           |:|||.....::
Mouse   437 LIDSSYLCQFCPSKFSTYFQLKSHMIQHKKEQVYKCVVKSCAQMFPKLDTFLEHIRSHQEELSYR 501

  Fly   340 CVQCDKGFINYSSLLLHQKTH-IAP---------------------------------TETFICP 370
            |..|.|.|.:...|.:||.:| :.|                                 |.:|.||
Mouse   502 CHLCSKDFPSLYDLGVHQYSHSLLPQHSPKKDSTVYKCVKCVNKYSTPEALEHHVQTATHSFPCP 566

  Fly   371 ECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQS 435
            .|::.|..|..|..|:..|.....::|.||::.||....|..|...|.||||:.||:|:.:|.:.
Mouse   567 HCQKVFPCERYLRRHLPTHGSGGRFRCQICKKFFRKEHYLKLHAHIHSGEKPYKCSVCESAFNRK 631

  Fly   436 GSLNIHMRIHTGEKPFQCKL-----CDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLN 495
            ..|..||.||...|.::|..     |.|.|.:...|..|:..|||.|.:.|.:|.||:|::|:|.
Mouse   632 DKLKRHMLIHEPFKKYKCPFSMHTGCSKEFNRQDKLKAHILSHAGLKLHKCGLCSKSFSRRAHLA 696

  Fly   496 KHIQAH 501
            :|.:||
Mouse   697 EHQRAH 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	59/288 (20%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..293	CDD:290200	13/24 (54%)
		C2H2 Zn finger	284..304	CDD:275368	4/19 (21%)
		zf-H2C2_2	296..321	CDD:290200	10/93 (11%)
		zf-C2H2_2	312..>387	CDD:289522	29/138 (21%)
		C2H2 Zn finger	312..332	CDD:275368	9/49 (18%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	10/29 (34%)
		C2H2 Zn finger	453..473	CDD:275368	6/24 (25%)
		zf-H2C2_2	465..490	CDD:290200	10/24 (42%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
Zfp341	NP_955008.2	COG5048	321..726	CDD:227381	95/382 (25%)
		zf-C2H2	321..342	CDD:278523	8/20 (40%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		zf-H2C2_2	334..359	CDD:290200	13/24 (54%)
		C2H2 Zn finger	350..370	CDD:275368	4/19 (21%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		C2H2 Zn finger	472..494	CDD:275368	2/21 (10%)
		C2H2 Zn finger	502..522	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..561	CDD:275370	0/21 (0%)
		C2H2 Zn finger	565..585	CDD:275368	7/19 (37%)
		C2H2 Zn finger	593..613	CDD:275368	7/19 (37%)
		zf-H2C2_2	605..630	CDD:290200	11/24 (46%)
		C2H2 Zn finger	621..641	CDD:275368	7/19 (37%)
		C2H2 Zn finger	649..674	CDD:275368	6/24 (25%)
		C2H2 Zn finger	682..702	CDD:275368	8/19 (42%)
		C2H2 Zn finger	710..727	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000