DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zbtb17

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001365755.1	Gene:	Zbtb17 / 22642	MGIID:	107410	Length:	819	Species:	Mus musculus

Alignment Length:	675	Identity:	170/675 - (25%)
Similarity:	247/675 - (36%)	Gaps:	214/675 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PQQAPNPPQQQPQQPQPPDLTFHCMC------------------CAEFFVHPLALYQHMNTLH-- 71
            ||.:....:|..||.|   |...|.|                  |:|:|  .:......:.:|
Mouse     4 PQHSQRVLEQLNQQRQ---LGLLCDCTFVVDGVDFKAHKAVLAACSEYF--KMLFVDQKDVVHLD 63

  Fly    72 -PHEPGNGQ-----------QEQESPGD--------ESEDYSWIFEPVCELAEDGS---DSSDGS 113
             .:..|.||           ...|:..|        :.:|.......:..|||..|   :|:|.|
Mouse    64 ISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVASFLQMQDIVTACHTLKSLAEPSSTTGESADAS 128

  Fly   114 ASSGSDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPG 178
            |..|.|..:.        |:.::::..|..:.:..|||                       .|||
Mouse   129 AVEGGDKRAK--------DEKAAATMLSRLDQARGSSS-----------------------TGPG 162

  Fly   179 YNEFQLQMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQST----------PIKRRRG 233
             .|.:.:.....||.|...| |.:..:||.....|.|...|..|.:.|          |::.:..
Mouse   163 -RELKEERGGQAESASSGPV-PAMEESPLASGQSPNPASRPSSGAEQTEKADAPREPPPVELKPD 225

  Fly   234 RRSNIGAP-------------VMDPALNG------------------------------------ 249
            ..|::.|.             .::||..|
Mouse   226 PTSSMAAAEAEALSESSEQEMEVEPASKGEDGQEEEGAGPATVKEEGMHLDNGEPPEENEESAGT 290

  Fly   250 ----------------------NQKCF-----QCTHCEASFPNAGDLSKHVRSHITNKPFQCSIC 287
                                  ..|.:     :|..|...|.:.|:..:|:|.|...|||.|..|
Mouse   291 DSGQELGMEGQNLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCREC 355

  Fly   288 QKTF-----------TH-----------------IGSLNTHIRIHSGEKPYKCELCPKAFTQSSS 324
            .|.|           ||                 |..||.|.:.||||..|:|..|.|.||.|.:
Mouse   356 SKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCGDCGKLFTTSGN 420

  Fly   325 LMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMH 389
            |..|...||.:||:||..|.:.|.:.:|.:.|.:||....| ..||.|:::|.....|..|:::|
Mouse   421 LKRHQLVHSGQKPYQCDYCGRSFSDPTSKMRHLETHDTDKE-HKCPHCDKKFNQVGNLKAHLKIH 484

  Fly   390 TQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCK 454
            ..:...:|..|.:.|..|..|.:|::.|.||||:.|:.|.|.|...|:|..|:||||||||.||.
Mouse   485 IADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCTHCQRQFADPGALQRHVRIHTGEKPCQCV 549

  Fly   455 LCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAK 519
            :|.|.|||||||..|::.|.|||||.|..|||.:.|.:.|..||:.|...
Mouse   550 ICGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNI--------------- 599

  Fly   520 QPHETLVCIVCGSLHADATALASHV 544
            :||:   |.||.....:...|:.|:
Mouse   600 RPHK---CSVCSKAFVNVGDLSKHI 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	58/191 (30%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	10/35 (29%)
		C2H2 Zn finger	284..304	CDD:275368	10/47 (21%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	27/74 (36%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	15/24 (63%)
		C2H2 Zn finger	453..473	CDD:275368	11/19 (58%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
Zbtb17	NP_001365755.1	BTB_POZ_ZBTB17_MIZ1	2..113	CDD:349515	19/113 (17%)
		PRK07003	<115..>266	CDD:235906	36/183 (20%)
		COG5048	322..653	CDD:227381	113/319 (35%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..372	CDD:275368	4/19 (21%)
		C2H2 Zn finger	380..400	CDD:275368	4/19 (21%)
		C2H2 Zn finger	408..428	CDD:275368	8/19 (42%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
		C2H2 Zn finger	548..568	CDD:275368	11/19 (58%)
		C2H2 Zn finger	576..596	CDD:275368	8/19 (42%)
		C2H2 Zn finger	604..624	CDD:275368	5/18 (28%)
		C2H2 Zn finger	632..651	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010