DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and znf-782

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	618	Identity:	154/618 - (24%)
Similarity:	225/618 - (36%)	Gaps:	195/618 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TLHPHEPG----------NGQQEQESPGDESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSS 123
            ||..|:|.          :.:..:|...:|.||         ||.|:
Worm     2 TLDYHQPTTTNTTLPDDIHMKDPEEEEFEEYED---------ELLEE------------------ 39

  Fly   124 SDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTD 188
             :::.|::.::..:|.|:||..|:.|....::||.:           ||
Worm    40 -EEEFDEELEELENSDSASSLVSAGSPHGSSSSNGS-----------HG---------------- 76

  Fly   189 PRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNGNQKC 253
                                 ..||....||..|..|:            |:|...|     :|.
Worm    77 ---------------------SSPPLQVQSPSQGSGSS------------GSPTGQP-----EKR 103

  Fly   254 FQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKA 318
            ..||.|...|.....|..|.|||...||:.|..|||||....:|..|.|.|:||:||||..|.|.
Worm   104 HICTVCGKGFSYFSILESHKRSHTGEKPYNCHFCQKTFAQKATLQVHERTHTGERPYKCRYCEKT 168

  Fly   319 FTQSSSLMVHMRS-HSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALL 382
            |.|..:..||.:| |...:.::|.:|||...:.|:|..|:|||  ..:||.|..|.:.|..:..|
Worm   169 FAQYGTKTVHEKSAHLGIRNYKCPKCDKLLSSPSALYTHKKTH--GDKTFRCDFCPKTFALKNYL 231

  Fly   383 DEHMR-MHTQ-ELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIH 445
            ..|:: :|.| |..:.|..|.:.|..:..|..|::.|.||:|:.|..|.::|...|:|..|.|.|
Worm   232 KLHVKQVHEQNERKHVCVYCNKGFAYAGSLQVHVRTHTGERPYVCKFCPKAFASQGNLQSHERTH 296

  Fly   446 TGEKPFQCKLCDKCFTQ------------------------------------------------ 462
            |||:|:.|:.|.:.|.|
Worm   297 TGERPYSCQFCQRTFIQKSQLTAHESTHLTQKHSVNPDSTTADILPVAGSVTDHQMVGNYECTFC 361

  Fly   463 ------ASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQP 521
                  ||||.:||:.|..:..|.|..|||.|||:..||.|....:.......:|.     ::..
Worm   362 NKKYPYASSLYIHMRKHTEKSAYSCDGCGKPYSQKISLNIHQDQCEAFKNRLKTTD-----SQFS 421

  Fly   522 HETLVCIVCGSLHADATALASHVHS----QHAALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYV 582
            |.   |..||.......||..||.|    ::.|.|...:|...|            ...:.::..
Worm   422 HN---CDGCGKSFVQRIALQIHVDSCEPHKNLARLKLSQQQNQN------------QNSDSESDT 471

  Fly   583 ERVQCVLQQ--MNHQQQHQQ-------HQQQPP 606
            |...|.|..  :.....|||       :.||||
Worm   472 EMKICPLPNPPLTLAPTHQQIPPPVNIYAQQPP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	59/161 (37%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	13/24 (54%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		zf-C2H2_2	312..>387	CDD:289522	26/75 (35%)
		C2H2 Zn finger	312..332	CDD:275368	8/20 (40%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	5/20 (25%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		zf-H2C2_2	409..434	CDD:290200	9/24 (38%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	11/24 (46%)
		C2H2 Zn finger	453..473	CDD:275368	10/73 (14%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	10/19 (53%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	7/19 (37%)
		zf-H2C2_2	119..143	CDD:290200	13/23 (57%)
		C2H2 Zn finger	134..154	CDD:275368	9/19 (47%)
		zf-H2C2_2	147..171	CDD:290200	13/23 (57%)
		C2H2 Zn finger	162..180	CDD:275368	7/17 (41%)
		COG5048	<187..404	CDD:227381	63/218 (29%)
		C2H2 Zn finger	191..211	CDD:275370	8/19 (42%)
		C2H2 Zn finger	218..239	CDD:275368	5/20 (25%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		zf-H2C2_2	260..285	CDD:290200	9/24 (38%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:290200	11/24 (46%)
		C2H2 Zn finger	304..324	CDD:275368	4/19 (21%)
		C2H2 Zn finger	386..403	CDD:275368	9/16 (56%)
		C2H2 Zn finger	424..441	CDD:275368	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000