DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and unc-98

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_509284.2	Gene:	unc-98 / 181020	WormBaseID:	WBGene00006827	Length:	310	Species:	Caenorhabditis elegans

Alignment Length:	250	Identity:	68/250 - (27%)
Similarity:	99/250 - (39%)	Gaps:	52/250 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 APTVSPGLGLQS--TPIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSH 276
            ||||...:|..|  ||.|...|            ||:|:.:                  :.||..
Worm    65 APTVEAYVGSSSAQTPTKSSGG------------ALDGSDQ------------------QEVRQD 99

  Fly   277 ITNKP--------FQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHS 333
            .|:..        ::|..|..||..:.:|..|.|||...:||.|..|..:|..:..|..|...||
Worm   100 GTSVQKDDNGFVFYKCRFCGLTFNFMNTLRAHERIHDVSQPYVCGKCGDSFEFACQLEYHAAQHS 164

  Fly   334 VRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECE--REFKAEALLDEHMRMHTQELVYQ 396
            ....::| :|.:.|.:|:.:|.|:.|. .|.|....||..  :..|...|     .:..|:|. |
Worm   165 EIDGYKC-ECGRTFFSYTEMLYHKHTD-DPLELIGAPETTTIKVSKKRVL-----PVSEQDLP-Q 221

  Fly   397 CAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPF 451
            .|...|.:.....|  .:.|.:..||:.|..|.:|::.|..|..||..|.|||.|
Worm   222 PAFVTEGYEPKHPL--RVYNDVRSKPYICEYCSKSYSDSRGLAYHMYSHRGEKYF 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	40/168 (24%)
		C2H2 Zn finger	256..276	CDD:275368	2/19 (11%)
		zf-H2C2_2	268..293	CDD:290200	7/32 (22%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	10/24 (42%)
		zf-C2H2_2	312..>387	CDD:289522	20/76 (26%)
		C2H2 Zn finger	312..332	CDD:275368	5/19 (26%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	4/21 (19%)
		C2H2 Zn finger	397..417	CDD:275368	3/19 (16%)
		zf-H2C2_2	409..434	CDD:290200	7/24 (29%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	7/14 (50%)
		C2H2 Zn finger	453..473	CDD:275368
		zf-H2C2_2	465..490	CDD:290200
		C2H2 Zn finger	481..501	CDD:275368
unc-98	NP_509284.2	C2H2 Zn finger	115..135	CDD:275368	7/19 (37%)
		C2H2 Zn finger	143..163	CDD:275368	5/19 (26%)
		SFP1	<169..268	CDD:227516	29/108 (27%)
		C2H2 Zn finger	171..189	CDD:275368	6/18 (33%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100