DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12299 and ztf-15

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_492052.2	Gene:	ztf-15 / 172470	WormBaseID:	WBGene00011066	Length:	729	Species:	Caenorhabditis elegans

Alignment Length:	757	Identity:	129/757 - (17%)
Similarity:	192/757 - (25%)	Gaps:	341/757 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YHHLP-----LTITPILQQTHLLPQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQHMN 68
            ||.:|     ..|..|..:..|.|....|.|....|                       :.:.:|
Worm    21 YHDMPDEKLLRHIKAIFDEASLRPSLTKNVPSTSSQ-----------------------VTEELN 62

  Fly    69 TLHPHEPGNGQQEQESPGDESEDYSWIFE---PVCELAEDGSDS------SDGSAS--------- 115
            .:...:|.:..|:        |.|..|||   .|.....|||.|      ||.|..
Worm    63 KVEIRDPKHEMQD--------EQYLSIFENPSGVQYNQADGSFSWNNRFHSDNSVQYINVLNNYG 119

  Fly   116 -SGSDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGY 179
             .|:|:..:..|..|:.|:......:...|..|.|:
Worm   120 CEGADTLLNQSDSSDETDESIEERRTPRGNRQSRSN----------------------------- 155

  Fly   180 NEFQLQMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMD 244
                                                       |.|.|..:...:|..      |
Worm   156 -------------------------------------------LTSKPSAKYWTKRGG------D 171

  Fly   245 PALNGNQKCFQCTHCEASFPNAGDLSKH-VRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGE- 307
            |.:|    | .|:.|.:.|.....|..| .:.|.......|.:|.|.|    |..|||.:|..:
Worm   172 PIVN----C-SCSICGSKFSTIRCLLDHRHQEHSLKDMMMCGLCGKEF----SKRTHIYLHLSQE 227

  Fly   308 -KPYKCELCPKAFTQSSSLMVHM------------------------------------------ 329
             |.|.|:.|..:|.....|..|.
Worm   228 YKVYHCDGCNTSFASKWHLEKHRCKENETIDDKKRRRTGRVNAEEIKVIKEEIQDEEFGGVVLSN 292

  Fly   330 ----RSHSVRKPHQCVQCDKGFINYSSLLLHQ--------------------------------- 357
                :|...|....||.|.|.:.:|..||.|:
Worm   293 ENHEKSKEDRFQFACVLCGKKYQHYHWLLKHRTKCLETTDEIQEFKCNVCYRRYNSSFWFERHME 357

  Fly   358 ----KTHIAPT---ETFICPECEREFKAE---------------ALLDEHMRMH----------- 389
                .|.:.|.   :|..||.|.::::.|               ||.|.|:.::
Worm   358 KCNSSTALPPALLDQTISCPNCHKKYQNEYWFDYHKKHCPDITPALSDVHLDVNSLRDRRPREGE 422

  Fly   390 ------------------------------------TQELV-YQCAICREAFRASSELVQHMKN- 416
                                                |..|| ..|:||.:.....:.|:.|.|.
Worm   423 ISVVPDVNLFGIEPEREDDNDDDEDADATISSSSSSTGNLVNIPCSICGKFCVGVASLLHHRKQI 487

  Fly   417 HMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPY-- 479
            |......||.:|.:.|....|:..||.:.  ...|:|:.|.:.....::|..|...    |||
Worm   488 HGLTAMLTCGVCTKKFNTLSSIRRHMSME--YSIFRCQQCGRNCIDRTTLDRHECF----KPYKI 546

  Fly   480 --------------PCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQPH-------- 522
                          .||.|..:::....|::|.:..|..:.......||....:|.|
Worm   547 RDKRLFNIQNISVLKCPDCRATFANLNVLSEHRKTCQYGNVFDNIQQPGSSSLRQHHRSDTNGAA 611

  Fly   523 ----------------ETLVCIVCGSLHADATALASHVHSQH 548
                            |...|..|.:...:..||.||.|..|
Worm   612 LQRKITSRVRLDSNTPEKWTCRDCHASFHNLQALCSHRHESH 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	50/310 (16%)
		C2H2 Zn finger	256..276	CDD:275368	5/20 (25%)
		zf-H2C2_2	268..293	CDD:290200	7/25 (28%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	10/26 (38%)
		zf-C2H2_2	312..>387	CDD:289522	26/175 (15%)
		C2H2 Zn finger	312..332	CDD:275368	5/65 (8%)
		C2H2 Zn finger	340..360	CDD:275368	8/56 (14%)
		C2H2 Zn finger	369..389	CDD:275368	8/34 (24%)
		C2H2 Zn finger	397..417	CDD:275368	6/20 (30%)
		zf-H2C2_2	409..434	CDD:290200	8/25 (32%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..462	CDD:290200	6/24 (25%)
		C2H2 Zn finger	453..473	CDD:275368	4/19 (21%)
		zf-H2C2_2	465..490	CDD:290200	8/40 (20%)
		C2H2 Zn finger	481..501	CDD:275368	5/19 (26%)
ztf-15	NP_492052.2	C2H2 Zn finger	178..199	CDD:275368	5/20 (25%)
		C2H2 Zn finger	207..223	CDD:275368	8/19 (42%)
		C2H2 Zn finger	233..250	CDD:275368	4/16 (25%)
		SFP1	<337..395	CDD:227516	7/57 (12%)
		C2H2 Zn finger	467..488	CDD:275368	6/20 (30%)
		C2H2 Zn finger	496..514	CDD:275368	5/17 (29%)
		C2H2 Zn finger	522..538	CDD:275368	3/15 (20%)
		C2H2 Zn finger	562..581	CDD:275368	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100