DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12299 and F57C9.4

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_491459.1	Gene:	F57C9.4 / 172100	WormBaseID:	WBGene00019011	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	156/792 - (19%)
Similarity:	247/792 - (31%)	Gaps:	342/792 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LTITPILQQTH---LLPQQAPNPPQQ----------------QPQQPQPPDLTFHCM-------- 51
            :.|.||.::.|   .||...| |||:                |.|:.:..:||....
Worm    99 MVIEPINREKHSGKTLPLSHP-PPQERCDYVLQLYAKEKVQHQSQKTKVEELTKQLQQARVDYNT 162

  Fly    52 ----CCAEFFVHPLALYQHMNTLHPHEPGNGQQEQESPGDESEDYSWIFEPVCELAEDGSDSSDG 112
                |  :|....:||.:.:.:    ..|:|.:::..  |:||. :.|.:..|...:||.
Worm   163 LKQRC--DFQEKEIALLRQITS----STGSGNRKRSR--DDSET-THIKKRRCGCGDDGE----- 213

  Fly   113 SASSGSDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQ--------SQE-SVQ 168
              |.|||.....||::|:.|.|.....::::....:::...|.:.:::.|        ||. |:.
Worm   214 --SCGSDCDGMDDDEEDETDTDVQMFRAATAQLQMAAAGRNTQNGTSSHQKLKRKIPKSQSVSIG 276

  Fly   169 PLHGLVAGP------------GYN----------------------------------------E 181
            ...|:|..|            |||                                        |
Worm   277 NARGMVTLPNLLQPKLEESDDGYNYSGRSSTQSNIDKLELAVRRESIVDIGRAVIDGIKNKTLTE 341

  Fly   182 FQLQ---MTDPRESTSIF-----------------MVQPTVSVTPLQQLLPPAPTVSPG------ 220
            .||:   .|..|.:.|||                 |:..||    :.::|.|......|
Worm   342 NQLEEFCKTTHRPNISIFRFYKDSEECTKEENEAIMMGQTV----MMKMLDPQEKAIAGVQASIS 402

  Fly   221 -----------LGLQSTPIKRRRGRRSNIGAPV-------MDPALN-----GNQKCFQCTH---- 258
                       |||    ||.:|..||.:..||       :..|.|     |.....|.|:
Worm   403 SLSASFANQTKLGL----IKHQRLTRSYVTLPVDYFPSIDLTEAYNSSNLFGADATMQLTNFYQT 463

  Fly   259 ------------------------CE---ASFP-------------------------------- 264
                                    |:   ..||
Worm   464 VLKNVLNPVYMIWIYTYRPSTVRTCDKHFVEFPQNVITTLFDMTTDIVGLYLPEYLLDGEIDPMD 528

  Fly   265 ------NAGDLSKHVRSHITNKPFQCSICQKTFTH-IGSLNTHIR-----------IHSGEKPYK 311
                  :|.|..:.:....|.:    .:...||.| :|....::|           ::..||. .
Worm   529 PFLLTIDAVDPFEEIMRRRTER----KLANTTFNHALGRAMKNLRSYHYDPTRGILLNCSEKK-N 588

  Fly   312 C-------------ELCPK--------------AFTQSSSLMVHMRSHS---------------- 333
            |             |.|.|              ||...:| .||...:|
Worm   589 CGMHLQWEQMRKFREYCRKENVACDDATPEEMIAFNLRAS-KVHYEDYSPGNVSSEEGNKNEMPN 652

  Fly   334 ------------VRKPH---------QCVQCDKGFINYSSLLL-------HQKTHIAPTETFICP 370
                        |:.|:         ..::.:.|......|||       :||. :...:..||.
Worm   653 FMEQLEKFSSVIVKGPNLPSTSTMSTMHIKMENGKEQSGPLLLRNSPNDQNQKV-VGVVQYVICQ 716

  Fly   371 EC-EREFKAEAL-----LDEH-MRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLC 428
            .| |.|.|:..|     ::|| :..|..:...:|..|.........:.||.:.|. ...|.|..|
Worm   717 LCPEEEQKSMDLSNQKQMEEHFLNKHVDKEKKKCEACPSDQFQPHNIGQHYRLHT-NSVFACEHC 780

  Fly   429 D----RSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYS 489
            .    |:|     |..|:|.||||:|::|..|.|.||.||:|..|..:|.|||.|.||:||::.:
Worm   781 GKRGRRNF-----LKTHIRTHTGERPYRCDTCSKSFTDASTLRRHGLVHTGEKKYQCPVCGRAIA 840

  Fly   490 QQAYLNKHIQAH 501
            ::..:..||::|
Worm   841 RKDNVKAHIRSH 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	45/317 (14%)
		C2H2 Zn finger	256..276	CDD:275368	6/88 (7%)
		zf-H2C2_2	268..293	CDD:290200	4/24 (17%)
		C2H2 Zn finger	284..304	CDD:275368	5/31 (16%)
		zf-H2C2_2	296..321	CDD:290200	9/62 (15%)
		zf-C2H2_2	312..>387	CDD:289522	27/152 (18%)
		C2H2 Zn finger	312..332	CDD:275368	9/46 (20%)
		C2H2 Zn finger	340..360	CDD:275368	6/26 (23%)
		C2H2 Zn finger	369..389	CDD:275368	8/26 (31%)
		C2H2 Zn finger	397..417	CDD:275368	4/19 (21%)
		zf-H2C2_2	409..434	CDD:290200	8/28 (29%)
		C2H2 Zn finger	425..445	CDD:275368	7/23 (30%)
		zf-H2C2_2	437..462	CDD:290200	12/24 (50%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
F57C9.4	NP_491459.1	C2H2 Zn finger	750..770	CDD:275368	4/19 (21%)
		C2H2 Zn finger	777..796	CDD:275368	7/23 (30%)
		zf-H2C2_2	789..812	CDD:290200	11/22 (50%)
		zf-C2H2	802..824	CDD:278523	9/21 (43%)
		C2H2 Zn finger	804..824	CDD:275368	9/19 (47%)
		zf-C2H2	830..852	CDD:278523	7/21 (33%)
		C2H2 Zn finger	832..852	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I3373
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050