DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and ZNF366

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_689838.1	Gene:	ZNF366 / 167465	HGNCID:	18316	Length:	744	Species:	Homo sapiens

Alignment Length:	492	Identity:	138/492 - (28%)
Similarity:	213/492 - (43%)	Gaps:	73/492 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDP---ALNGNQKCFQCTHCEASFPNAGDLSKHV 273
            ||.|.:......|.:...:::..|.::...:.|.   .:.|:||.:||..||.|:.:..:|..|:
Human   208 PPEPLLPRKAEPQESEETKQKVERVDVNVQIDDSYYVDVGGSQKRWQCPTCEKSYTSKYNLVTHI 272

  Fly   274 RSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPH 338
            ..|...||..|:.|.|.|..:..|:||:..|.|.:|:||::|.|||||:|.|..||..||..|||
Human   273 LGHSGIKPHACTHCGKLFKQLSHLHTHMLTHQGTRPHKCQVCHKAFTQTSHLKRHMMQHSEVKPH 337

  Fly   339 QCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREA 403
            .|..|.:||...|.|..|:..|.:..|. ||.||..:|...|.|..|:..|...:.|.|:.|.:.
Human   338 NCRVCGRGFAYPSELKAHEAKHASGREN-ICVECGLDFPTLAQLKRHLTTHRGPIQYNCSECDKT 401

  Fly   404 FRASSELVQHMKNHMGEKPFTCS----------------------------LCDRSFTQSGSLNI 440
            |:..|:|..||..|...:|:.||                            :|.|.||...::..
Human   402 FQYPSQLQNHMMKHKDIRPYICSECGMEFVQPHHLKQHSLTHKGVKEHKCGICGREFTLLANMKR 466

  Fly   441 HMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMAS 505
            |:.|||..:.:||.||.|.|.|..:|..||.:|:..||:.|.:|||.:::...|..|:..|
Human   467 HVLIHTNIRAYQCHLCYKSFVQKQTLKAHMIVHSDVKPFKCKLCGKEFNRMHNLMGHMHLH---- 527

  Fly   506 AASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIPD 570
               :.:.|           ..|:.|.|.......|..|:..:|..:...:...|:..   |.|
Human   528 ---SDSKP-----------FKCLYCPSKFTLKGNLTRHMKVKHGVMERGLHSQGLGR---GRI-- 573

  Fly   571 VKCSAEEQQAYVERVQCVLQQMNHQQQHQQHQQQPP---------QQQQQHPQQQQQQHLQQQPH 626
                |..|.|.|.|   .|:|.......|:.:.:.|         |....|.::::....:.:|:
Human   574 ----ALAQTAGVLR---SLEQEEPFDLSQKRRAKVPVFQSDGESAQGSHCHEEEEEDNCYEVEPY 631

  Fly   627 QMQL-PQQPKL-PAMDSTGEDEEEPDEAEEPPDEEEE 661
            ...| ||..:| ...|.:.:.|..|:..||...||:|
Human   632 SPGLAPQSQQLCTPEDLSTKSEHAPEVLEEACKEEKE 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	61/158 (39%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	9/24 (38%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	33/74 (45%)
		C2H2 Zn finger	312..332	CDD:275368	11/19 (58%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	10/52 (19%)
		C2H2 Zn finger	425..445	CDD:275368	7/47 (15%)
		zf-H2C2_2	437..462	CDD:290200	10/24 (42%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	10/24 (42%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
ZNF366	NP_689838.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..228		4/19 (21%)
		COG5048	253..>549	CDD:227381	99/314 (32%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..331	CDD:275368	11/19 (58%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..443	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		Interaction with NRIP1. /evidence=ECO:0000269\|PubMed:17085477	455..744		61/244 (25%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..554	CDD:275368	5/18 (28%)
		PXDLS. /evidence=ECO:0000269\|PubMed:16393996, ECO:0000269\|PubMed:17085477	590..594		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..627		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..692		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1498
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940