DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and ZNF296

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_660331.1	Gene:	ZNF296 / 162979	HGNCID:	15981	Length:	475	Species:	Homo sapiens

Alignment Length:	542	Identity:	118/542 - (21%)
Similarity:	170/542 - (31%)	Gaps:	175/542 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HHLP---------LTITPILQQTHLLPQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQ 65
            ||.|         |.:.|....|...| ..||.|.:||...:.||| ..|..|.:.|
Human    67 HHSPGPMPAGAALLALGPRNPWTLWTP-LTPNYPDRQPWTDKHPDL-LTCGRCLQTF-------- 121

  Fly    66 HMNTLHPHEPGNGQQEQESPGDESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDDDDDD 130
                  |.|......:.:..|             |:|.. |.....||
Human   122 ------PLEAITAFMDHKKLG-------------CQLFR-GPSRGQGS----------------- 149

  Fly   131 DDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQ-----LQMTDPR 190
                                            .:|.::.|..|..|   .:|.     |:.....
Human   150 --------------------------------EREELKALSCLRCG---KQFTVAWKLLRHAQWD 179

  Fly   191 ESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNGNQKCFQ 255
            ...||:..:......||..|...|..||                      .|:.||
Human   180 HGLSIYQTESEAPEAPLLGLAEVAAAVS----------------------AVVGPA--------- 213

  Fly   256 CTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFT 320
               .||..|.|..      |.:|.:...|.:|:||.:...:|..|:|.|:||:||.|:.||.|..
Human   214 ---AEAKSPRASG------SGLTRRSPTCPVCKKTLSSFSNLKVHMRSHTGERPYACDQCPYACA 269

  Fly   321 QSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTH-IAPTETFICPECEREFKAE----- 379
            |||.|..|.::|....|...:..|......|:.......| .|||.|..|...|....|.
Human   270 QSSKLNRHKKTHRQVPPQSPLMADTSQEQASAAPPEPAVHAAAPTSTLPCSGGEGAGAAATAGVQ 334

  Fly   380 -------------------ALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTC 425
                               |:..|   ..|.....|        :||.:.:............:|
Human   335 EPGAPGSGAQAGPGGDTWGAITTE---QRTDPANSQ--------KASPKKMPKSGGKSRGPGGSC 388

  Fly   426 SLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHA---GEKPYPCPICGKS 487
            ..|.:.||.|.:|.:|.|.||||:|:.|:.|:....|:|.|:.|.::|.   |...:.||.|...
Human   389 EFCGKHFTNSSNLTVHRRSHTGERPYTCEFCNYACAQSSKLNRHRRMHGMTPGSTRFECPHCHVP 453

  Fly   488 YSQQAYLNKHIQAHQMASAASA 509
            :..:|.|:||::.....:|..|
Human   454 FGLRATLDKHLRQKHPEAAGEA 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	45/183 (25%)
		C2H2 Zn finger	256..276	CDD:275368	4/19 (21%)
		zf-H2C2_2	268..293	CDD:290200	6/24 (25%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	23/99 (23%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	2/19 (11%)
		C2H2 Zn finger	369..389	CDD:275368	5/43 (12%)
		C2H2 Zn finger	397..417	CDD:275368	2/19 (11%)
		zf-H2C2_2	409..434	CDD:290200	3/24 (13%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	10/24 (42%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		zf-H2C2_2	465..490	CDD:290200	7/27 (26%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
ZNF296	NP_660331.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78		3/10 (30%)
		zf-C2H2	232..253	CDD:306579	7/20 (35%)
		C2H2 Zn finger	233..253	CDD:275370	7/19 (37%)
		zf-H2C2_2	245..270	CDD:316026	12/24 (50%)
		C2H2 Zn finger	261..281	CDD:275370	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..385		19/120 (16%)
		zf-C2H2_2	387..>467	CDD:315435	28/79 (35%)
		zf-C2H2	387..408	CDD:306579	8/20 (40%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		zf-H2C2_2	400..425	CDD:316026	10/24 (42%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..465	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000