DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Zfp358

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_536709.2	Gene:	Zfp358 / 140482	MGIID:	2153740	Length:	571	Species:	Mus musculus

Alignment Length:	712	Identity:	187/712 - (26%)
Similarity:	278/712 - (39%)	Gaps:	199/712 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ITPILQQTHLLPQ------QAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQHMNTLHPHE 74
            :.|:....|..|:      :.|:|..:.| :|:|.||                     ||:  .|
Mouse    15 LRPLYGDLHSDPEDLDSSPKDPDPISESP-EPEPEDL---------------------NTV--SE 55

  Fly    75 PGNGQQEQESP-GDESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDDDDDDDD------ 132
            .|:...|...| .||:        |...|.:...||.|      .|..|||.|.|.|.|
Mouse    56 DGDASLEDLDPEADEA--------PRSILGKPDLDSQD------LDPMSSSFDLDPDPDVIGPVP 106

  Fly   133 ---DDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTDPRESTS 194
               |.|:.:.|.::....|..|                    ||.|.|
Mouse   107 LVLDPSNDTPSPAAPDVDSLPS--------------------GLTATP----------------- 134

  Fly   195 IFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHC 259
                          ::|..:|.|.|                    ||...|      :.|.|..|
Mouse   135 --------------EILATSPAVLP--------------------APASPP------RPFSCPDC 159

  Fly   260 EASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSS 324
            ..:|..:..||:|.|:|...||::|..|.|:|:|..:|..|..||:|.:||:|..|.|||...|:
Mouse   160 GRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGWRST 224

  Fly   325 LMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMH 389
            |:.|..|||..|||.|..|.|.|.:.|.|..|.:||..| ....||.|.:.|...:.|.:|:|.|
Mouse   225 LLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGP-RPHKCPVCAKGFGQGSALLKHLRTH 288

  Fly   390 TQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCK 454
            |.|..|.|..|.:||..||.|:||.:.|..|:|:.|..|.::|.||.:|..|:||||||:|:.|.
Mouse   289 TGERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFGQSSNLQHHLRIHTGERPYACP 353

  Fly   455 LCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTS------- 512
            .|.|.|.|:|:|..|:.:|:||:||.|.:|||::.|.:.|.||.:.|:.|:||:|:.:
Mouse   354 HCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAAAA 418

  Fly   513 ------------------PGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQSG 559
                              ||.:....|....|......|.:.|::..|   |...::|.:::...
Mouse   419 AAAGLGLGSGLSPVSMMRPGQISFLGPDAVSVLESGLGLSSGASSARS---SAPTSVLGSLQNPI 480

  Fly   560 MNTAPGG-AIPDVKCSAEEQQAYVERVQCVLQQMNHQQQHQQHQQQPPQQQQQHPQQQQQQHLQQ 623
            :.|..|. :.||:..|::.:..:|.....|                |...|:..|.
Mouse   481 LQTHSGSISSPDLVLSSDPKPGHVADPDVV----------------PSPDQESDPS--------- 520

  Fly   624 QPHQMQLPQQPKLPAMDSTGEDEEEPDEAEEPPDEEEEQDEPEEPAEVKTEVLAAEDALTNP 685
                   |....:|:.|      .:|....:|.....:...|..|.....:.:..|.||..|
Mouse   521 -------PNPDLVPSPD------PKPKSQTDPCSPTHDSSSPALPTGESPKWVKEEGALLGP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	65/158 (41%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	11/24 (46%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	30/74 (41%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		zf-H2C2_2	409..434	CDD:290200	9/24 (38%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	13/24 (54%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
Zfp358	NP_536709.2	zf-C2H2	154..176	CDD:278523	8/21 (38%)
		C2H2 Zn finger	156..176	CDD:275368	7/19 (37%)
		zf-H2C2_2	169..193	CDD:290200	11/23 (48%)
		C2H2 Zn finger	184..204	CDD:275368	7/19 (37%)
		zf-H2C2_2	197..219	CDD:290200	10/21 (48%)
		C2H2 Zn finger	212..232	CDD:275368	8/19 (42%)
		zf-H2C2_2	225..247	CDD:290200	11/21 (52%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		zf-H2C2_2	253..275	CDD:290200	8/22 (36%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		zf-H2C2_2	280..303	CDD:290200	9/22 (41%)
		zf-C2H2_8	295..373	CDD:292531	34/77 (44%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		zf-H2C2_2	308..331	CDD:290200	8/22 (36%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	336..359	CDD:290200	12/22 (55%)
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..387	CDD:290200	11/22 (50%)
		zf-C2H2	378..400	CDD:278523	9/21 (43%)
		C2H2 Zn finger	380..400	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3267
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960