Protein Alignment CG12299 and ZNF358

DIOPT Version :10

• Sequence 1: NP_609448.1
• Gene: CG12299 / 34483
• FlyBaseID: FBgn0032295
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_047294137.1
• Gene: ZNF358 / 140467
• HGNCID: 16838
• Length: 587
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 177/537 - (32%)
• Similarity: 253/537 - (47%)
• Gaps: 88/537 - (16%)

  Fly    70 LHPHEPGNGQQEQ------ESPGDESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDDDD 128
            |.|...|....|.      .:||.:.      ..||.|  |..|||.|...:. .|....|:|.:
Human     8 LAPEAAGTSTPEMRRSVLVRNPGHKG------LRPVYE--ELDSDSEDLDPNP-EDLDPVSEDPE 63

  Fly   129 DDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQP----LHGLVAGPGYNEFQLQMTDP 189
            .|.:|               .::||    .:...|.|.::|    |......|| :|.|    ||
Human    64 PDPED---------------LNTVP----EDVDPSYEDLEPVSEDLDPDAEAPG-SEPQ----DP 104

  Fly   190 RESTSIFMVQPTVSVTPLQQLLPP-APTVSPG--------LGLQSTPIKRRRGRRSNIGAPVMDP 245
            ...:|.|.:.|.| :.|:..:|.| :.|:|||        .||.:||       :....:|.:.|
Human   105 DPMSSSFDLDPDV-IGPVPLILDPNSDTLSPGDPKVDPISSGLTATP-------QVLATSPAVLP 161

  Fly   246 ALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPY 310
            |.....:.|.|..|..:|..:..||:|.|:|...||::|..|.|:|:|..:|..|..||:|.:||
Human   162 APASPPRPFSCPDCGRAFRRSSGLSQHRRTHSGEKPYRCPDCGKSFSHGATLAQHRGIHTGARPY 226

  Fly   311 KCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECERE 375
            :|..|.|||...|:|:.|..|||..|||.|..|.|.|.:.|.|..|.:||..| ....||.|.:.
Human   227 QCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGP-RPHKCPVCAKG 290

  Fly   376 FKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNI 440
            |...:.|.:|:|.||.|..|.|..|.:||..||.|:||.:.|..|:|:.|..|.::|.||.:|..
Human   291 FGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFGQSSNLQH 355

  Fly   441 HMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMAS 505
            |:||||||:|:.|..|.|.|.|:|:|..|:.:|:||:||.|.:|||::.|.:.|.||.:.|:.|:
Human   356 HLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHKRVHEGAA 420

  Fly   506 AASASTS-------------PGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAAL-LDTMK 556
            ||:|:.:             |||..|.......|.:    |..||.::..      :.| |....
Human   421 AAAAAAAAAAAAAAAGLGLGPGLSPASMMRPGQVSL----LGPDAVSVLG------SGLGLSPGT 475

  Fly   557 QSGMNTAPG---GAIPD 570
            .||.|..||   |.:||
Human   476 SSGRNPDPGSGPGTLPD 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	245..>501	CDD:227381	107/255 (42%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:463886	12/24 (50%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		zf-H2C2_2	409..434	CDD:463886	9/24 (38%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:463886	13/24 (54%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
ZNF358	XP_047294137.1	COG5048	<54..358	CDD:227381	112/336 (33%)
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		zf-H2C2_2	185..209	CDD:463886	11/23 (48%)
		C2H2 Zn finger	200..220	CDD:275368	7/19 (37%)
		C2H2 Zn finger	228..248	CDD:275368	8/19 (42%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		zf-H2C2_2	352..375	CDD:463886	12/22 (55%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		zf-H2C2_2	380..403	CDD:463886	11/22 (50%)
		zf-C2H2	394..416	CDD:395048	9/21 (43%)
		C2H2 Zn finger	396..416	CDD:275368	8/19 (42%)