DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and si:ch211-235i11.4

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_021322935.1	Gene:	si:ch211-235i11.4 / 103909096	ZFINID:	ZDB-GENE-131126-23	Length:	1567	Species:	Danio rerio

Alignment Length:	404	Identity:	130/404 - (32%)
Similarity:	190/404 - (47%)	Gaps:	46/404 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 PGLGLQSTPIKRRRG--------------RRSNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDL 269
            |.|......:|.|||              |.|::...||   ::..:|.|.||.|..|:.....|
Zfish   903 PQLQTSDVYLKNRRGKNPCICTECGKSFKRLSSLNQHVM---IHTGEKPFTCTQCGMSYSRLSYL 964

  Fly   270 SKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSV 334
            ..|:|.|...:||:|:.|.|:||.....|.|:.||:||:||||:.|.|.|..||.|.||:|.|:.
Zfish   965 KNHMRIHTGERPFKCNECGKSFTQSTYFNRHMMIHTGERPYKCDQCGKTFLSSSQLKVHLRVHTK 1029

  Fly   335 RKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAI 399
            .||:.|..|.|.|...::|..|||.|....| ::|.|||:.|.....|..|.|:||:|..|.|:.
Zfish  1030 EKPYYCSDCGKSFTQLANLGKHQKIHTGMKE-YMCFECEKTFITAGELKVHQRIHTEEKPYTCSH 1093

  Fly   400 CREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQAS 464
            |.:.|.....|..|...|.||||:.||.||:.|.|.|.|..|..|||||||::|..|:|.|....
Zfish  1094 CNKGFGQLGRLKAHQMIHTGEKPYKCSHCDKGFCQLGKLKTHQMIHTGEKPYKCSHCNKGFHVLD 1158

  Fly   465 SLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCIV 529
            .|.:|.:||.|||||.|..|.|.:||...:..|.:.|               ..::|:   .|..
Zfish  1159 HLKMHERIHTGEKPYKCSYCDKRFSQSGGMKTHERTH---------------TGERPY---TCDQ 1205

  Fly   530 CGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYVERVQCVLQQMNH 594
            |.........|..|:.:.....:.|.:.:..:..|        |..:::.| .|::..:.:.:..
Zfish  1206 CLKSFTRLFHLQKHMKTHSGEEMHTDRANMSDPEP--------CRIKQEDA-EEQIDLIEEHVEI 1261

  Fly   595 QQQHQQ-HQQQPPQ 607
            :::.|. ..::.||
Zfish  1262 KEEKQYIKAEETPQ 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	64/158 (41%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	10/24 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		zf-C2H2_2	312..>387	CDD:289522	30/74 (41%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		zf-H2C2_2	409..434	CDD:290200	12/24 (50%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		zf-H2C2_2	437..462	CDD:290200	13/24 (54%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		zf-H2C2_2	465..490	CDD:290200	12/24 (50%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
si:ch211-235i11.4	XP_021322935.1	C2H2 Zn finger	110..130	CDD:275368
		zf-H2C2_2	122..147	CDD:316026
		C2H2 Zn finger	138..158	CDD:275368
		COG5048	162..634	CDD:227381
		C2H2 Zn finger	166..186	CDD:275368
		C2H2 Zn finger	194..214	CDD:275368
		C2H2 Zn finger	222..242	CDD:275368
		C2H2 Zn finger	250..270	CDD:275368
		C2H2 Zn finger	278..298	CDD:275368
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368
		C2H2 Zn finger	362..382	CDD:275368
		C2H2 Zn finger	390..410	CDD:275368
		C2H2 Zn finger	418..438	CDD:275368
		C2H2 Zn finger	487..507	CDD:275368
		C2H2 Zn finger	515..535	CDD:275368
		C2H2 Zn finger	543..563	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		C2H2 Zn finger	599..619	CDD:275368
		C2H2 Zn finger	627..647	CDD:275368
		COG5048	651..1070	CDD:227381	63/170 (37%)
		C2H2 Zn finger	655..675	CDD:275368
		C2H2 Zn finger	683..703	CDD:275368
		C2H2 Zn finger	711..731	CDD:275368
		C2H2 Zn finger	739..759	CDD:275368
		C2H2 Zn finger	767..787	CDD:275368
		C2H2 Zn finger	795..815	CDD:275368
		C2H2 Zn finger	923..943	CDD:275368	4/22 (18%)
		C2H2 Zn finger	951..971	CDD:275368	7/19 (37%)
		C2H2 Zn finger	979..999	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1007..1027	CDD:275368	10/19 (53%)
		C2H2 Zn finger	1035..1055	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1063..1083	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1091..1111	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1119..1139	CDD:275368	9/19 (47%)
		COG5048	1143..1561	CDD:227381	35/160 (22%)
		C2H2 Zn finger	1147..1167	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1175..1195	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1203..1223	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1291..1311	CDD:275368
		C2H2 Zn finger	1319..1339	CDD:275368
		C2H2 Zn finger	1347..1367	CDD:275368
		C2H2 Zn finger	1375..1395	CDD:275368
		C2H2 Zn finger	1403..1423	CDD:275368
		C2H2 Zn finger	1431..1451	CDD:275368
		C2H2 Zn finger	1459..1479	CDD:275368
		C2H2 Zn finger	1487..1507	CDD:275368
		C2H2 Zn finger	1515..1535	CDD:275368
		C2H2 Zn finger	1543..1563	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910