DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and Znf768

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_006230430.1	Gene:	Znf768 / 102553763	RGDID:	7609558	Length:	567	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	157/527 - (29%)
Similarity:	221/527 - (41%)	Gaps:	113/527 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQHMNTLHP-----HEPGNGQQEQESPG 86
            |:.||..|:..||.|:              |....:.|:..:..:.     :|||:.:.|.:|||
  Rat    97 PEFAPRSPESDPQSPE--------------FESQSSRYEPQSPGYDPKSPGYEPGSPRYEPKSPG 147

  Fly    87 -----DESEDYSWIFEPVCELAEDGSDSSDGSASSGSDSSSSSDD-DDDDDDDDSSSSSSSSSNS 145
                 .|.|..|    |.||           |.|.|.:..:|.|: .:.:....|....:.||..
  Rat   148 YGSKSPEFESQS----PGCE-----------SQSPGYEPQNSGDEVRNSEFKTHSPEFETQSSKF 197

  Fly   146 SSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTDPRESTSIFMVQPTVSVTPLQQL 210
            ...:..:......|.......|.||.....|                   |..||| ...||
  Rat   198 QEGAEMLLNPEEKNPLNIPLGVHPLDSFTQG-------------------FGEQPT-GALPL--- 239

  Fly   211 LPPAPTVSPGLGLQSTP-------------IKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCEAS 262
              .||...|...|.:||             ..|..|||.........|..|      .|..|..|
  Rat   240 --GAPFDMPSGALLATPQFEMLQNPLNLTGTLRGPGRRGGRARGGQGPRPN------ICGICGKS 296

  Fly   263 FPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMV 327
            |.....|.:|.|.|...||::|.:|.|.|:....|..|.|.|:||:||||..|.|||..||.|:.
  Rat   297 FGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLR 361

  Fly   328 HMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQE 392
            |.|:||.:||::|..|.|.|.:.|.||.||:|| :....:.||||.:.:...:.|..|.|:||.:
  Rat   362 HQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTH-SHERPYSCPECGKCYSQNSSLRSHQRVHTGQ 425

  Fly   393 LVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNI----------------- 440
            ..:.|.||.::|...|.|:.|.::|..||||.|..|.:.|.||..|.|
  Rat   426 RPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCG 490

  Fly   441 -----------HMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYL 494
                       |.|.||||:|::|.:|.|.|.::|:|..|.::|:||:||.|..|||::||.:.|
  Rat   491 KTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDL 555

  Fly   495 NKHIQAH 501
            .:|.:.|
  Rat   556 IRHQRTH 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	63/158 (40%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	10/24 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	14/24 (58%)
		zf-C2H2_2	312..>387	CDD:289522	31/74 (42%)
		C2H2 Zn finger	312..332	CDD:275368	10/19 (53%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	9/47 (19%)
		zf-H2C2_2	437..462	CDD:290200	13/52 (25%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
Znf768	XP_006230430.1	C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		zf-H2C2_2	303..327	CDD:290200	10/23 (43%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		COG5048	<326..531	CDD:227381	75/205 (37%)
		zf-H2C2_2	330..354	CDD:290200	13/23 (57%)
		C2H2 Zn finger	346..366	CDD:275368	10/19 (53%)
		zf-H2C2_2	358..381	CDD:290200	10/22 (45%)
		zf-C2H2	372..394	CDD:278523	9/21 (43%)
		C2H2 Zn finger	374..394	CDD:275368	9/19 (47%)
		zf-C2H2	400..422	CDD:278523	7/21 (33%)
		C2H2 Zn finger	402..422	CDD:275368	7/19 (37%)
		zf-H2C2_2	414..439	CDD:290200	9/24 (38%)
		C2H2 Zn finger	430..450	CDD:275368	7/19 (37%)
		zf-H2C2_2	446..465	CDD:290200	8/18 (44%)
		zf-C2H2	456..478	CDD:278523	8/21 (38%)
		C2H2 Zn finger	458..478	CDD:275368	7/19 (37%)
		zf-C2H2	484..506	CDD:278523	2/21 (10%)
		C2H2 Zn finger	486..506	CDD:275368	2/19 (11%)
		zf-H2C2_2	499..521	CDD:290200	10/21 (48%)
		C2H2 Zn finger	514..534	CDD:275368	7/19 (37%)
		zf-H2C2_2	527..551	CDD:290200	11/23 (48%)
		zf-C2H2	540..562	CDD:278523	9/21 (43%)
		C2H2 Zn finger	542..562	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3218
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050