DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and znf1008

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_005171144.1	Gene:	znf1008 / 101886637	ZFINID:	ZDB-GENE-131121-84	Length:	390	Species:	Danio rerio

Alignment Length:	405	Identity:	131/405 - (32%)
Similarity:	200/405 - (49%)	Gaps:	46/405 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SGSDSSSSSDDDD---------DDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLH 171
            |.:::.:.:|:|.         :|::.:...||:|...|||.|.:.|...:.:..|..:|
Zfish     3 SDAETHTMTDEDTEGLAEQMKVEDEEVNEEKSSTSEEKSSSGSETAPPKGSFSCPQCGKS----- 62

  Fly   172 GLVAGPGYNEFQLQM-TDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRR 235
              ....|:.|..:.: |..|..|                 .|.........|......:...|.|
Zfish    63 --FTRKGHLEVHMVIHTGERPYT-----------------CPQCAKSFTCKGSLKDHFRIHTGER 108

  Fly   236 -----------SNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQK 289
                       :|.|.......::..::.|.|..|..|||::|:|.:|:|.|..::|:.|..|.|
Zfish   109 PFTCPQCEKSFTNSGGLKRHLRIHTGERPFTCRQCAKSFPSSGELKRHMRIHSRDRPYTCPQCGK 173

  Fly   290 TFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLL 354
            ::.....|..|.:.||||||:.|.||.|:|||.|:|.|||:.||..|.|||.:|.:.|....:|.
Zfish   174 SYKQKEVLREHTKTHSGEKPFTCTLCGKSFTQQSTLKVHMKVHSGEKLHQCPECGRRFAEACNLK 238

  Fly   355 LHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMG 419
            .|..:|.. ...|.|.:||::|.....|..|||:|..|..|.|:.|.::|...:....|.|.|:|
Zfish   239 THLLSHTG-ERPFSCEKCEKKFFLAVHLKTHMRIHEDERRYVCSFCGKSFLWLNGFKDHQKTHIG 302

  Fly   420 EKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPIC 484
            |||:.|..|.::|.::..|.:|.||||||||::|..|:|.|||:|.|.||.::|.|||||.||.|
Zfish   303 EKPYECLECGKTFARAAELKVHERIHTGEKPYKCSHCEKSFTQSSGLKVHERVHTGEKPYLCPTC 367

  Fly   485 GKSYSQQAYLNKHIQ 499
            ||::|:...|.||::
Zfish   368 GKTFSRYGSLAKHLK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	61/158 (39%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		zf-H2C2_2	268..293	CDD:290200	8/24 (33%)
		C2H2 Zn finger	284..304	CDD:275368	5/19 (26%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		zf-C2H2_2	312..>387	CDD:289522	30/74 (41%)
		C2H2 Zn finger	312..332	CDD:275368	12/19 (63%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		zf-H2C2_2	409..434	CDD:290200	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..462	CDD:290200	14/24 (58%)
		C2H2 Zn finger	453..473	CDD:275368	10/19 (53%)
		zf-H2C2_2	465..490	CDD:290200	14/24 (58%)
		C2H2 Zn finger	481..501	CDD:275368	9/19 (47%)
znf1008	XP_005171144.1	C2H2 Zn finger	56..76	CDD:275368	4/26 (15%)
		zf-H2C2_2	68..93	CDD:290200	5/41 (12%)
		COG5048	80..>383	CDD:227381	114/321 (36%)
		C2H2 Zn finger	84..104	CDD:275368	2/19 (11%)
		zf-H2C2_2	96..121	CDD:290200	2/24 (8%)
		C2H2 Zn finger	112..132	CDD:275368	2/19 (11%)
		zf-H2C2_2	125..147	CDD:290200	3/21 (14%)
		C2H2 Zn finger	140..160	CDD:275368	9/19 (47%)
		zf-H2C2_2	152..177	CDD:290200	8/24 (33%)
		C2H2 Zn finger	168..188	CDD:275368	5/19 (26%)
		zf-H2C2_2	181..205	CDD:290200	13/23 (57%)
		C2H2 Zn finger	196..216	CDD:275368	12/19 (63%)
		zf-H2C2_2	209..232	CDD:290200	11/22 (50%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		C2H2 Zn finger	252..272	CDD:275368	8/19 (42%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		zf-H2C2_2	320..345	CDD:290200	14/24 (58%)
		C2H2 Zn finger	336..356	CDD:275368	10/19 (53%)
		zf-H2C2_2	349..373	CDD:290200	14/23 (61%)
		C2H2 Zn finger	364..382	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910