DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and si:ch1073-127d16.1

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_021323944.1	Gene:	si:ch1073-127d16.1 / 101883863	ZFINID:	ZDB-GENE-120214-30	Length:	454	Species:	Danio rerio

Alignment Length:	397	Identity:	135/397 - (34%)
Similarity:	178/397 - (44%)	Gaps:	62/397 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 PAPTVSPGLGLQS----TPIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHV 273
            |..|..|.|.:|:    |||:.....:.|          :..::.|.|..|..||.....|..|:
Zfish    19 PYFTEQPSLKIQTGDIFTPIQSLESHKVN----------HSEKQTFICAECGKSFTLKRYLKNHM 73

  Fly   274 RSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPH 338
            :.|....||.|..|.|.||...||.||::||:||||:.|..|.|.|....||..|:|.|:..||:
Zfish    74 KIHTGAHPFTCPECDKCFTMKHSLETHLKIHTGEKPFTCPDCGKKFRLKQSLDGHLRIHTGEKPY 138

  Fly   339 QCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREA 403
            .|..|.:.|.....|..|...|.. .:.:.||||.:.|:.:..|:.|:::||.|..|.|..|.::
Zfish   139 TCQVCGRSFREKQILDKHLTIHTG-EKPYSCPECGKSFRVKNCLENHIKIHTGEKPYTCQECGKS 202

  Fly   404 FRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSV 468
            |.....|.:|::.|.|||||.|..|.|||.....|.||:|||||||||.|:.|.|.|::...|..
Zfish   203 FTEKQNLERHIRIHTGEKPFACPECGRSFRVKQDLKIHLRIHTGEKPFSCQQCGKSFSENKKLEN 267

  Fly   469 HMKIHAGEK----------------------------PYPCPICGKSYSQQAYLNKHIQAHQ--- 502
            ||:||.|||                            ||.||.|||||:||..|..||:.|.
Zfish   268 HMRIHTGEKPFVCSHCGKNFRGKQNLESHMRLHTGNQPYTCPQCGKSYNQQKSLQIHIRTHTGEK 332

  Fly   503 -------MASAASASTSPGLLVAKQPHETLVCIVCGSLHADATALASH--VHS-------QHAAL 551
                   ..|....||..|.:......:...|..||....:.|.|..|  :||       ||...
Zfish   333 PFACDQCGKSFTQQSTLKGHIKIHTGEKPFTCPQCGKSFIEKTKLERHKKIHSGEKAYTCQHCKK 397

  Fly   552 LDTMKQS 558
            ..|:|||
Zfish   398 SFTLKQS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	57/158 (36%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	9/24 (38%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..321	CDD:290200	14/24 (58%)
		zf-C2H2_2	312..>387	CDD:289522	24/74 (32%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		zf-H2C2_2	409..434	CDD:290200	13/24 (54%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		zf-H2C2_2	437..462	CDD:290200	16/24 (67%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	17/52 (33%)
		C2H2 Zn finger	481..501	CDD:275368	12/19 (63%)
si:ch1073-127d16.1	XP_021323944.1	COG5048	36..445	CDD:227381	130/380 (34%)
		C2H2 Zn finger	56..76	CDD:275368	6/19 (32%)
		C2H2 Zn finger	84..104	CDD:275368	9/19 (47%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	140..160	CDD:275368	5/19 (26%)
		C2H2 Zn finger	168..188	CDD:275368	7/19 (37%)
		C2H2 Zn finger	196..216	CDD:275368	5/19 (26%)
		C2H2 Zn finger	224..244	CDD:275368	9/19 (47%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	0/19 (0%)
		C2H2 Zn finger	308..328	CDD:275368	12/19 (63%)
		C2H2 Zn finger	336..356	CDD:275368	4/19 (21%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	6/13 (46%)
		C2H2 Zn finger	420..440	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910