DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and si:cabz01071912.2

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_003198590.1	Gene:	si:cabz01071912.2 / 100535458	ZFINID:	ZDB-GENE-161017-141	Length:	351	Species:	Danio rerio

Alignment Length:	368	Identity:	125/368 - (33%)
Similarity:	180/368 - (48%)	Gaps:	38/368 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 FQLQMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPA 246
            |:::..||:|.|.:.:  |......|.:|....|..:..:.          |.|| :..|..:..
Zfish    17 FRVKQEDPQEQTDLLL--PKKENQDLNKLKIEDPHSNHFIA----------GERS-LRCPQTEKT 68

  Fly   247 -LNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPY 310
             |....|||:   ||..|.:.....:|:.:|.|:..|.|.:|.:...:..:...|:::|:.|||:
Zfish    69 FLQRANKCFE---CEKVFQSKKKFKEHMLTHFTDGCFTCQLCGRRCKNWRAFEHHMKVHTVEKPF 130

  Fly   311 KCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECERE 375
            .|:.|||.|.|..:|.:||:.|:..||..|.||.|.|....:|.||.|.|.. .:.|.|.:|...
Zfish   131 SCQQCPKTFAQKDNLKLHMKVHTGEKPFSCEQCPKTFARKDNLKLHMKVHTG-EKPFTCQQCGTT 194

  Fly   376 FKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNI 440
            |.....|..|:|:||.|..:.|..|.::|.....|..||:.|.|||||||..|.:.|:.|.:|||
Zfish   195 FARNDNLKSHIRVHTGEKPFTCPECGKSFIQQGILKVHMRIHSGEKPFTCQQCGKVFSHSLNLNI 259

  Fly   441 HMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMAS 505
            |||:|||||||.||.|.|.|:|..:|.:||:.|.||||:.|..||||:.....|..|::.|
Zfish   260 HMRVHTGEKPFTCKPCGKSFSQIGTLKLHMRTHTGEKPFSCQQCGKSFRVNMKLKNHMKVH---- 320

  Fly   506 AASASTSPGLLVAKQPHETLVCIVCGSLHADATALASH--VHS 546
                 |...|...:|         ||........|:||  ||:
Zfish   321 -----TGEKLFTCQQ---------CGVSFRVKKTLSSHMKVHA 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	51/158 (32%)
		C2H2 Zn finger	256..276	CDD:275368	4/19 (21%)
		zf-H2C2_2	268..293	CDD:290200	6/24 (25%)
		C2H2 Zn finger	284..304	CDD:275368	3/19 (16%)
		zf-H2C2_2	296..321	CDD:290200	10/24 (42%)
		zf-C2H2_2	312..>387	CDD:289522	28/74 (38%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:290200	13/24 (54%)
		C2H2 Zn finger	425..445	CDD:275368	10/19 (53%)
		zf-H2C2_2	437..462	CDD:290200	18/24 (75%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
si:cabz01071912.2	XP_003198590.1	C2H2 Zn finger	76..96	CDD:275368	6/22 (27%)
		C2H2 Zn finger	104..124	CDD:275368	3/19 (16%)
		C2H2 Zn finger	132..152	CDD:275368	9/19 (47%)
		zf-H2C2_2	144..169	CDD:290200	11/24 (46%)
		COG5048	<156..316	CDD:227381	72/160 (45%)
		C2H2 Zn finger	160..180	CDD:275368	9/19 (47%)
		zf-H2C2_2	172..197	CDD:290200	9/25 (36%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		zf-H2C2_2	200..225	CDD:290200	9/24 (38%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		zf-H2C2_2	229..253	CDD:290200	13/23 (57%)
		C2H2 Zn finger	244..264	CDD:275368	10/19 (53%)
		zf-H2C2_2	256..281	CDD:290200	18/24 (75%)
		C2H2 Zn finger	272..292	CDD:275368	9/19 (47%)
		zf-H2C2_2	285..307	CDD:290200	12/21 (57%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		C2H2 Zn finger	328..348	CDD:275368	6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910