DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and si:dkey-262g12.3

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_009299305.1	Gene:	si:dkey-262g12.3 / 100534843	ZFINID:	ZDB-GENE-060503-255	Length:	389	Species:	Danio rerio

Alignment Length:	399	Identity:	125/399 - (31%)
Similarity:	193/399 - (48%)	Gaps:	33/399 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 FQLQMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPA 246
            |.::..||.::....:.:.|..:..:::......||.     :||.|||....:.:     .:..
Zfish    17 FTIKQEDPGQTELTMLKEETQELNEMEEKDQDLKTVE-----KSTKIKRTSPHKRD-----QETK 71

  Fly   247 LNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYK 311
            ..||..|.||..|   |....:|..|:.:|...||..|..|.|:|.....|..|:|||:||||:.
Zfish    72 STGNFTCSQCGKC---FAQKHNLRVHMSAHTREKPHLCPECGKSFRRKQYLAVHMRIHTGEKPFS 133

  Fly   312 CELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREF 376
            |:.|.|:|.||..|..|:|.|:..||:.|.||...:|:...|..|...| ...:.|:||:|.:.|
Zfish   134 CDQCGKSFRQSIILRHHIRLHTGEKPYACPQCGVRYIHKQRLEKHMAVH-NEDKPFVCPQCGKSF 197

  Fly   377 KAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIH 441
            .....|.:||::||.|..:.|..|.::|....::..||:.|.||:|:.||.|.:||||.|:|:.|
Zfish   198 TLNLNLKQHMKIHTGEKPFVCQQCGKSFNHKQQVEVHMRVHTGERPYICSQCGKSFTQKGNLDHH 262

  Fly   442 MRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASA 506
            ||.|..|:|:.|..|.:..|..|||..||:.|..:|||.|..||:|:::::.|..|.:||
Zfish   263 MRTHARERPYTCTKCGRNLTSQSSLDAHMRTHTEKKPYACSECGQSFAKRSVLKVHRRAH----- 322

  Fly   507 ASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIP-D 570
                         ...:|..|..||..:...|.|.||:.:..........|.|.:....|::. .
Zfish   323 -------------TGEQTYTCTRCGKNYTSKTYLKSHMRTHTGEKPFVCGQCGKSFYHRGSLSYH 374

  Fly   571 VKCSAEEQQ 579
            :|..:|||:
Zfish   375 MKSHSEEQK 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	55/158 (35%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		zf-H2C2_2	268..293	CDD:290200	9/24 (38%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		zf-C2H2_2	312..>387	CDD:289522	26/74 (35%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	12/19 (63%)
		zf-H2C2_2	437..462	CDD:290200	9/24 (38%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	12/24 (50%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
si:dkey-262g12.3	XP_009299305.1	COG5048	<54..225	CDD:227381	62/179 (35%)
		C2H2 Zn finger	78..98	CDD:275368	7/22 (32%)
		C2H2 Zn finger	106..126	CDD:275368	7/19 (37%)
		C2H2 Zn finger	134..154	CDD:275368	9/19 (47%)
		C2H2 Zn finger	162..182	CDD:275368	6/19 (32%)
		C2H2 Zn finger	190..210	CDD:275368	7/19 (37%)
		C2H2 Zn finger	218..238	CDD:275368	5/19 (26%)
		SFP1	<235..323	CDD:227516	40/105 (38%)
		C2H2 Zn finger	246..266	CDD:275368	12/19 (63%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..367	CDD:316026	5/24 (21%)
		C2H2 Zn finger	358..378	CDD:275368	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910