DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12299 and LOC100333012

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_021331506.1	Gene:	LOC100333012 / 100333012	-ID:	-	Length:	949	Species:	Danio rerio

Alignment Length:	669	Identity:	160/669 - (23%)
Similarity:	236/669 - (35%)	Gaps:	182/669 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QLKQSYH-----HLPLTITPILQQTHLLPQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLAL 63
            :||:.|.     |....:.|..|.....|:::......:....:.|   |.|..|.:.|:.....
Zfish   383 ELKKRYRTHLRIHTKKRLFPCAQCGKRFPKESDLQYHMKDHAVKKP---FKCGQCGKGFIIKNRY 444

  Fly    64 YQHMNTLHPHE---PGNGQQEQESPGDES-----EDYSWIFEPVCE-LAEDGSDSSDGSASSGSD 119
            ..||. :|..|   | ..|.|:..|.:..     :|:: :.:||.: |..:|
Zfish   445 RTHMR-MHAEERLFP-CAQCEKRFPTERDLRCHMKDHA-VEKPVEQSLLRNG------------- 493

  Fly   120 SSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQL 184
               ||:||..|.||......:....|.|..|.:......:|.:.
Zfish   494 ---SSNDDRIDHDDQKLFPCAQCGKSFSKESDLQCHVKDHTVEK--------------------- 534

  Fly   185 QMTDPRESTSIFMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNG 249
                                 |::|.|                  .|.|..::      |...:.
Zfish   535 ---------------------PVEQSL------------------LRNGSSND------DRTDHD 554

  Fly   250 NQKCFQCTHCEASFPNAGDLSKHVRSHIT-----------------------NKPFQCSICQKTF 291
            :||.|.|..|..|||...||..||:.|..                       .|||.|..|.|:|
Zfish   555 DQKSFPCGQCGKSFPKESDLQCHVKDHAVEKPVDQSLLRNGSLNDDRTDHDDQKPFPCGQCGKSF 619

  Fly   292 THIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLH 356
            ........|::.|:.|||:||..|.|.||.......|||.|:..:...|.||.|.|.....|..|
Zfish   620 PKERDRRCHMKDHAVEKPFKCGKCGKGFTSKKWYQTHMRMHAQERLIPCAQCGKRFPKERDLRRH 684

  Fly   357 QKTHIAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEK 421
            .|.| |..:.|.|.:|.:.|.::.....|||:|.:|.::.||.|.::|...|:|..|||:|..:|
Zfish   685 LKDH-AVGKPFQCGQCGKGFTSKKRYQNHMRIHVEERLFPCAQCEKSFSKESDLQCHMKSHPVQK 748

  Fly   422 PFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKP-------- 478
            ||.|..|.:.||.......|.|:|..|:...|..|.|.|.:...|..|||.||.|||
Zfish   749 PFKCGKCGKGFTSKKWYRTHKRMHVQERLIPCAQCGKRFPKEKDLRRHMKDHAVEKPVEQSLLRN 813

  Fly   479 ---------------YPCPICGKSYSQQAYLNKHIQAHQMA-------SAASASTSPGLLVAKQP 521
                           :||..||||:|::..||.|.:.|...       .....|...|:...::.
Zfish   814 GSSYHGRTDHDDQKSFPCVQCGKSFSEKLSLNAHKKIHFRGVIFKCKRCGKRFSNKAGIKAHRKT 878

  Fly   522 HET---LVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYVE 583
            |.|   .||..||.:..:...| ||...:|                   :.:|.|....::|...
Zfish   879 HATPRPYVCGTCGKIFNNKQTL-SHHEMRH-------------------VKEVPCEGRAERALRR 923

  Fly   584 RVQ---CVLQQMNHQQQHQ 599
            |.:   .||:.:....:.|
Zfish   924 REKLDNSVLEDLRSDVEAQ 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	58/181 (32%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		zf-H2C2_2	268..293	CDD:290200	12/47 (26%)
		C2H2 Zn finger	284..304	CDD:275368	5/19 (26%)
		zf-H2C2_2	296..321	CDD:290200	10/24 (42%)
		zf-C2H2_2	312..>387	CDD:289522	24/74 (32%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..462	CDD:290200	8/24 (33%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	15/47 (32%)
		C2H2 Zn finger	481..501	CDD:275368	9/19 (47%)
LOC100333012	XP_021331506.1	C2H2 Zn finger	103..123	CDD:275370
		C2H2 Zn finger	131..151	CDD:275368
		C2H2 Zn finger	206..226	CDD:275368
		SFP1	<230..278	CDD:227516
		C2H2 Zn finger	234..254	CDD:275368
		SFP1	<257..326	CDD:227516
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	291..311	CDD:275368
		C2H2 Zn finger	319..339	CDD:275368
		COG5048	342..799	CDD:227381	124/504 (25%)
		C2H2 Zn finger	347..367	CDD:275368
		C2H2 Zn finger	375..395	CDD:275368	3/11 (27%)
		C2H2 Zn finger	403..423	CDD:275368	2/19 (11%)
		C2H2 Zn finger	431..451	CDD:275368	5/20 (25%)
		C2H2 Zn finger	459..479	CDD:275368	3/19 (16%)
		C2H2 Zn finger	510..530	CDD:275368	3/19 (16%)
		C2H2 Zn finger	561..581	CDD:275368	9/19 (47%)
		C2H2 Zn finger	612..632	CDD:275368	5/19 (26%)
		C2H2 Zn finger	640..660	CDD:275368	8/19 (42%)
		C2H2 Zn finger	668..688	CDD:275368	8/19 (42%)
		C2H2 Zn finger	696..716	CDD:275368	6/19 (32%)
		C2H2 Zn finger	724..744	CDD:275368	9/19 (47%)
		COG5048	<747..905	CDD:227381	46/158 (29%)
		C2H2 Zn finger	752..772	CDD:275368	6/19 (32%)
		C2H2 Zn finger	780..800	CDD:275368	8/19 (42%)
		C2H2 Zn finger	831..851	CDD:275368	9/19 (47%)
		C2H2 Zn finger	859..879	CDD:275368	2/19 (11%)
		C2H2 Zn finger	887..907	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910