DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and zgc:174653

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001108366.1	Gene:	zgc:174653 / 100141328	ZFINID:	ZDB-GENE-080218-2	Length:	392	Species:	Danio rerio

Alignment Length:	378	Identity:	122/378 - (32%)
Similarity:	173/378 - (45%)	Gaps:	62/378 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 LNGNQKC-FQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGEKPY 310
            ||...:| |.|.....||....:|..|:|.|...|.:.|..|.|:|..|..|..|:|||.||:.|
Zfish    46 LNYKSECNFSCKQSRKSFSQKPNLGVHMRVHNREKHYTCKQCGKSFPKIHFLKAHMRIHIGERSY 110

  Fly   311 KCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQCDKGFINYSSLLLHQKTHIAPTETFICPECERE 375
            .|:.|.|.|..:.:|.||||.|:..||:.|.||.|.|...::|.:|.:||.. ..:|.|.:|.:.
Zfish   111 TCQQCGKIFHYARNLAVHMRIHTGEKPYSCPQCGKSFKQNNNLEVHMRTHTG-ERSFTCTQCGKS 174

  Fly   376 FKAEALLDEHMRMHTQELVYQCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNI 440
            |..:..|..|||:||.|..:.|..|.::||..|.|..|.:.|.||||:.|:.|.:||....:.|.
Zfish   175 FAKKQNLKIHMRIHTGEKPFTCTECGKSFRNKSTLNIHKRTHTGEKPYRCTECGKSFPNKSTFNN 239

  Fly   441 HMRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMAS 505
            ||||||||||::|..|.|.|.:.|:|:.|::.|.|||.:.|..||||::.:..|..|:..|
Zfish   240 HMRIHTGEKPYRCTECGKSFIRKSTLNYHVRTHTGEKLFACVQCGKSFTTKLSLMNHMNGH---- 300

  Fly   506 AASASTSPGLLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIPD 570
                   .|.:|       ..|..||.......::..|                |.|..|
Zfish   301 -------TGTIV-------FTCDQCGKSLTRKDSIKRH----------------MKTHSG----- 330

  Fly   571 VKCSAEEQQAYVERVQC--VLQQMNHQQQHQQHQQQPPQQQQQHPQQQQQQHL 621
                        ||.:|  ..:...|::..:.|       .:.|..:|..|||
Zfish   331 ------------ERFRCSECGKDFKHERSLRAH-------MKLHNSEQSPQHL 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	60/158 (38%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	9/24 (38%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	12/24 (50%)
		zf-C2H2_2	312..>387	CDD:289522	27/74 (36%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	11/24 (46%)
		C2H2 Zn finger	425..445	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..462	CDD:290200	15/24 (63%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	11/24 (46%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
zgc:174653	NP_001108366.1	C2H2 Zn finger	56..76	CDD:275368	6/19 (32%)
		C2H2 Zn finger	84..104	CDD:275368	8/19 (42%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		COG5048	<117..363	CDD:227381	92/304 (30%)
		zf-H2C2_2	124..149	CDD:290200	13/24 (54%)
		C2H2 Zn finger	140..160	CDD:275368	7/19 (37%)
		zf-H2C2_2	152..176	CDD:290200	7/24 (29%)
		C2H2 Zn finger	168..188	CDD:275368	7/19 (37%)
		zf-H2C2_2	180..205	CDD:290200	10/24 (42%)
		C2H2 Zn finger	196..216	CDD:275368	7/19 (37%)
		zf-H2C2_2	209..231	CDD:290200	9/21 (43%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		zf-H2C2_2	237..261	CDD:290200	15/23 (65%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	5/35 (14%)
		C2H2 Zn finger	335..355	CDD:275370	3/26 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910