DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12299 and Zbtb48

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_017175372.1	Gene:	Zbtb48 / 100090	MGIID:	2140248	Length:	767	Species:	Mus musculus

Alignment Length:	720	Identity:	148/720 - (20%)
Similarity:	240/720 - (33%)	Gaps:	240/720 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 CCAEFF------------VHPLA-------LYQHMNTLH-PHEPGNGQQ----EQESPGDESEDY 92
            ||:.||            |.|..       |.....|.| ....||..|    .:|....|:.:.
Mouse    76 CCSHFFQRIYGDGTGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAAKELRVPEAVEL 140

  Fly    93 SWIFEPVCELAEDGSDSSDGSASSGSDSSSSSD-------DDDDDDDDDSSSSSSSSSNSSSSSS 150
            ...|:|         .:|.|.|.||....:|.|       ..|.|:::...:.|.:|.:.....:
Mouse   141 CQSFQP---------QTSVGQAQSGLGQPASQDVKSHLKEPTDLDEEEVFRTLSLASVDQEPRDT 196

  Fly   151 SVP--------TT-------------SNSNTQQSQESVQPLHGLVAGPG-----YNEFQ--LQMT 187
            ..|        ||             |.|..::|::..:|.....||..     .||::  :|:.
Mouse   197 EQPQLGTPAQSTTAFLCGKLTQALKPSPSEDKESEDCKEPPRPFEAGGAPLQGESNEWEVVVQVE 261

  Fly   188 DPRESTSIFMVQPTVSVTPLQQLLPPAP-TVSPGLG---LQSTPIKRRRGRRSNIGAPVMDPAL- 247
            |.|:..  ::.:|...:|..:..:...| ...|.||   |.:.|...|:|....:..|......
Mouse   262 DDRDGD--YVSEPETVLTRRKSKVIRKPCAAEPALGAGSLTAEPTDSRKGAAVPVECPTCHKKFL 324

  Fly   248 -----------NGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKP---FQCSICQKTFTHIGSLN 298
                       :..:|.|:|..|...:....:|.:|...:..|:.   |.||:||:||.....|.
Mouse   325 SKYYLKVHNRKHTGEKPFECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELR 389

  Fly   299 THIRIHSGEKPYKCELCPKAFTQSSSLMVHM-RSHSVRKPH-----------------QCVQCD- 344
            .|:..|:||.||||..|.:.|.|...|..|| :.|...|||                 .|...|
Mouse   390 LHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHAVSASQGWGSGGSGTAQSCPHLDV 454

  Fly   345 ---------------------------------------------------------------KG 346
                                                                           ||
Mouse   455 LPLPVSPTCSAPLVPSASCLGRSYSCTRLLSIVEKSSLCVRNAGTGPRAATDCRCTSRPSTGMKG 519

  Fly   347 FINYSSLLLHQKTHIAPTETFIC----------------PECEREFKAEALLDEHMRMHTQELVY 395
            .::.||..:.....  ||.|..|                |...:..:|:.||...:|......:.
Mouse   520 LMSVSSAAMPSPRR--PTSTCTCAHTPARSLSSATSVGRPSAPKVRQAQPLLAPGLRQPLSSTLS 582

  Fly   396 QCAICREAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRI-HTGEKPFQCKLCDKC 459
            ..|          .|.:|.:.|.||:||:|..|::.||:.|.|..|:.. |...:|..|::|.|.
Mouse   583 PIA----------SLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKT 637

  Fly   460 FTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPG---------- 514
            |.....|.||::.|.|.:.:.|..||..:::||:|.:|::.|....    :.:|.
Mouse   638 FKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVE----NYNPRQRKLRNLIIE 698

  Fly   515 ----LLVAKQPHETLVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIPDVKCSA 575
                ::||.||            .||....::.|      :::::.|.|:    ...:|..:..:
Mouse   699 DEKMVVVALQP------------PADLEVGSAEV------IVESLTQGGL----ASQLPSQRLCS 741

  Fly   576 EEQQA 580
            ||..|
Mouse   742 EESFA 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	49/259 (19%)
		C2H2 Zn finger	256..276	CDD:275368	4/19 (21%)
		zf-H2C2_2	268..293	CDD:290200	10/27 (37%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..321	CDD:290200	11/24 (46%)
		zf-C2H2_2	312..>387	CDD:289522	25/172 (15%)
		C2H2 Zn finger	312..332	CDD:275368	7/20 (35%)
		C2H2 Zn finger	340..360	CDD:275368	6/83 (7%)
		C2H2 Zn finger	369..389	CDD:275368	6/35 (17%)
		C2H2 Zn finger	397..417	CDD:275368	3/19 (16%)
		zf-H2C2_2	409..434	CDD:290200	10/24 (42%)
		C2H2 Zn finger	425..445	CDD:275368	7/20 (35%)
		zf-H2C2_2	437..462	CDD:290200	8/25 (32%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	8/24 (33%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
Zbtb48	XP_017175372.1	BTB_POZ_ZBTB48_TZAP_KR3	38..145	CDD:349541	14/68 (21%)
		C2H2 Zn finger	316..336	CDD:275368	1/19 (5%)
		zf-H2C2_2	328..351	CDD:372612	4/22 (18%)
		C2H2 Zn finger	344..395	CDD:275368	14/50 (28%)
		zf-H2C2_2	387..410	CDD:372612	10/22 (45%)
		C2H2 Zn finger	403..424	CDD:275368	7/20 (35%)
		PHA03247	<426..583	CDD:223021	18/158 (11%)
		zf-H2C2_2	586..610	CDD:372612	9/23 (39%)
		C2H2 Zn finger	602..623	CDD:275368	7/20 (35%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		zf-H2C2_2	644..668	CDD:372612	8/23 (35%)
		zf-C2H2	657..679	CDD:333835	7/21 (33%)
		C2H2 Zn finger	659..679	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910