DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12299 and zgc:172128

DIOPT Version :9

Sequence 1:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_001107945.1	Gene:	zgc:172128 / 100002012	ZFINID:	ZDB-GENE-080220-2	Length:	442	Species:	Danio rerio

Alignment Length:	435	Identity:	137/435 - (31%)
Similarity:	201/435 - (46%)	Gaps:	42/435 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 TTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTDPRESTSI-----FMVQPTVSVTPLQQLLPP 213
            |..:.:.:|.|.|...|.     ||..:.| .:.|.:|...:     .:...|.|....||..|.
Zfish    18 TVKHEDAEQLQLSCTDLM-----PGKKQIQ-DVNDVKEEKDLEEGGQLISGQTTSENSAQQTGPV 76

  Fly   214 APTVSPGLGLQSTPIKRRRGRRSNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHIT 278
            :.......| :|...||.......|         :..:|.|:|..|...|....:|:.|.|.|..
Zfish    77 SVFTCQQCG-KSLTTKRTLNDHMRI---------HNGEKLFRCQQCGKGFTTKTNLAVHKRIHTR 131

  Fly   279 NKPFQCSICQKTFTHIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPHQCVQC 343
            .||:.|..|...|:...||...:|||:|.|||.|:.|...:|...::.||||:|:.||||.|.:|
Zfish   132 EKPYMCPQCGNCFSTKTSLEVPMRIHTGTKPYLCQQCGNNYTTKQNIEVHMRTHTGRKPHICQEC 196

  Fly   344 DKGFINYSSLLLHQKTH--IAPTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICREAFRA 406
            ...||..:||..|.:.|  :.|   |.|.:|...|..:..|::||..||.|..:.|.:|.:.|..
Zfish   197 GVSFIYKTSLEEHMRNHPRLKP---FTCQQCGNRFTTKRNLEDHMITHTGEKPFTCELCGKGFTT 258

  Fly   407 SSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSLSVHMK 471
            .|.|..||:.|..|:|:||..|:||||:..||..|.|:|..||...|..|:.||...::|.||||
Zfish   259 KSNLKVHMRIHTEERPYTCEQCERSFTRKDSLESHRRMHMAEKSHACPHCEMCFELKTTLVVHMK 323

  Fly   472 IHAGEKPYPCPICGKSYSQQAYLNKHIQAHQ-----MASAASASTSPG--------LLVAKQPHE 523
            :|.|||.:.|..||||:.:.|.|.:|::.|.     |....|.|...|        ..:.::|:
Zfish   324 VHTGEKLFRCGQCGKSFGRNATLKRHMRVHSAESRFMCRQCSVSFPDGSQLKDHVRTHLGQKPY- 387

  Fly   524 TLVCIVCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAI 568
              :|:.||....:.|.|..|:.|.......|.::.|:..|.|.|:
Zfish   388 --LCLECGRSCTEITNLKIHMRSHTGERPFTCQECGLRFAYGKAL 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	58/160 (36%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..293	CDD:290200	9/24 (38%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-H2C2_2	296..321	CDD:290200	11/24 (46%)
		zf-C2H2_2	312..>387	CDD:289522	27/76 (36%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	12/24 (50%)
		C2H2 Zn finger	425..445	CDD:275368	10/19 (53%)
		zf-H2C2_2	437..462	CDD:290200	11/24 (46%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	14/24 (58%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
zgc:172128	NP_001107945.1	COG5048	63..435	CDD:227381	127/384 (33%)
		C2H2 Zn finger	81..101	CDD:275368	5/29 (17%)
		C2H2 Zn finger	109..129	CDD:275368	6/19 (32%)
		zf-H2C2_2	121..146	CDD:290200	9/24 (38%)
		UNC-79	<136..>246	CDD:291442	43/112 (38%)
		C2H2 Zn finger	137..157	CDD:275368	6/19 (32%)
		C2H2 Zn finger	165..185	CDD:275368	7/19 (37%)
		C2H2 Zn finger	193..213	CDD:275368	7/19 (37%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		zf-H2C2_2	233..258	CDD:290200	9/24 (38%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		zf-H2C2_2	261..286	CDD:290200	12/24 (50%)
		C2H2 Zn finger	277..297	CDD:275368	10/19 (53%)
		C2H2 Zn finger	305..322	CDD:275368	6/16 (38%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		C2H2 Zn finger	361..381	CDD:275368	3/19 (16%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..426	CDD:290200	5/24 (21%)
		C2H2 Zn finger	417..437	CDD:275368	4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840