DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup107 and NUP84

DIOPT Version :9

Sequence 1:	NP_609446.1	Gene:	Nup107 / 34481	FlyBaseID:	FBgn0027868	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_010167.1	Gene:	NUP84 / 851441	SGDID:	S000002274	Length:	726	Species:	Saccharomyces cerevisiae

Alignment Length:	816	Identity:	184/816 - (22%)
Similarity:	329/816 - (40%)	Gaps:	164/816 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 FPQFFDVLQ----AQGNGQ---EAFEVIQSLTQVCRGVVEQLELEIDHGMGGEQGARQRESMLTW 123
            |.:|.|.|:    .|.|.|   :.|.:|:..    |....||.|::.:. |.|...   .|...|
Yeast    12 FTKFSDTLKEFKIEQNNEQNPIDPFNIIREF----RSAAGQLALDLANS-GDESNV---ISSKDW 68

  Fly   124 LRQEINTWRLLHALFYDRILLQTDRQAD---DEMQDGP--TLGGSEKEVIQQLYALNATLREYQL 183
             ..|...|.|:.       ||...|.||   |||:..|  :.|..||:::|.    |..|.:..:
Yeast    69 -ELEARFWHLVE-------LLLVFRNADLDLDEMELHPYNSRGLFEKKLMQD----NKQLYQIWI 121

  Fly   184 VVDWLEACYDRGEQQNPLHAHDRMMAWENTLFQLENLQGAAFGKGHKIVT-----RLDPDAPVRE 243
            |:.||:                     ||| :.:|..:.....|....:|     ..|.|.|:||
Yeast   122 VMVWLK---------------------ENT-YVMERPKNVPTSKWLNSITSGGLKSCDLDFPLRE 164

  Fly   244 K-RPLHALDEEDNLRLSRAIFELIRAGRVDDGLKLCKHFGQTWRAAILEGWRLHEDPNFEQNVSV 307
            . ..|...|:|::....:.|:|||.||.:|:.|:..|.........||.|.:.:.:|..:..::
Yeast   165 NTNVLDVKDKEEDHIFFKYIYELILAGAIDEALEEAKLSDNISICMILCGIQEYLNPVIDTQIA- 228

  Fly   308 LHEKLPIEGNPRRDIWKRCAWMLADSKNYDEYSRATAGVFSGHLGSLKTLLHSNWHDLLWAHLKV 372
             :|....:|..:..:|:|..:.|:.....|.|.||.....||.:.:.:.|.:|:|...|..||.
Yeast   229 -NEFNTQQGIKKHSLWRRTVYSLSQQAGLDPYERAIYSYLSGAIPNQEVLQYSDWESDLHIHLN- 291

  Fly   373 QIDIRVESEIRGCCLKNYQ--------PMPDDYWNGRMTMEQIFEELNVAKDASVRDFAQSQ--L 427
            ||   :::||....|:|.|        |:|    :..:|::::...:      :.|..::|:  :
Yeast   292 QI---LQTEIENYLLENNQVGTDELILPLP----SHALTVQEVLNRV------ASRHPSESEHPI 343

  Fly   428 GIIQRHLILDTCGELIQHMVRW---VEKDTSQQS-----PHQLRFMAHIVLFLRQI--GRVEQER 482
            .::...:|||:...:|...|..   |.|.|...:     |:.||.:.|:.:.|..|  |.|| |.
Yeast   344 RVLMASVILDSLPSVIHSSVEMLLDVVKGTEASNDIIDKPYLLRIVTHLAICLDIINPGSVE-EV 407

  Fly   483 QAEKIVAAYVEALIARGEPQLIAYYTASLSNPLQVQLYSRFLEQVEQKRPRELAVDAALQAGLDV 547
            ...|::..|:..|..:|..:.|..|...|:....::..|..|..:|..:.|:..::......|..
Yeast   408 DKSKLITTYISLLKLQGLYENIPIYATFLNESDCLEACSFILSSLEDPQVRKKQIETINFLRLPA 472

  Fly   548 EQITRVTVQNI----RLAHQPLGEFGEPQSGEISAIDQRKISALEWLIHLPEQRGELLWQA---- 604
            ..|.|.|.|.:    ...:.|..|..  .|.:::.||...|..:||||     .|:|...|
Yeast   473 SNILRRTTQRVFDETEQEYSPSNEIS--ISFDVNNIDMHLIYGVEWLI-----EGKLYVDAVHSI 530

  Fly   605 NAMIRTYLASSKVECMRQTFRMVPADIVQQLVSLYGSVDNI--PPREECCLKEYLCYKAYLSGVD 667
            .|:.|.:|.:.:|:.:.|.........:.:...|....|||  ...|:..|:|...|:..:.|:.
Yeast   531 IALSRRFLLNGRVKALEQFMERNNIGEICKNYELEKIADNISKDENEDQFLEEITQYEHLIKGIR 595

  Fly   668 SFVEWNRLQQNRPKKPQTSHAASSQDNFTERMASERKEQAHRSEVVRWEHKVKEQAKQTIELLYN 732
            .:.||.:          :....||:.|....:                 .|::..:|.|.||:
Yeast   596 EYEEWQK----------SVSLLSSESNIPTLI-----------------EKLQGFSKDTFELI-- 631

  Fly   733 VLMFPDKGWLVDPFIAKLPENAVQLSWDHRLLQMEKLRSICIPEIALFLNEVMFKSGDFAGCVRL 797
                  |.:|||...:...::|     |:.:|.  ::|::..|.:.:.|::.:.::.......:.
Yeast   632 ------KTFLVDLTSSNFADSA-----DYEILY--EIRALYTPFLLMELHKKLVEAAKLLKIPKF 683

  Fly   798 ADE-------ISSENRQLYKVY-TKHKLAELLAKIA 825
            ..|       :::||.::|.:: :..||.|.|..:|
Yeast   684 ISEALAFTSLVANENDKIYLLFQSSGKLKEYLDLVA 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup107	NP_609446.1	Nup84_Nup100	121..828	CDD:309305	168/754 (22%)
NUP84	NP_010167.1	Nup84_Nup100	66..722	CDD:397996	168/754 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343081
Domainoid	1	1.000	96	1.000	Domainoid score	I1644
eggNOG	1	0.900	-	-		E1_KOG1964
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I1495
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56116
OrthoFinder	1	1.000	-	-		FOG0005073
OrthoInspector	1	1.000	-	-		oto98971
orthoMCL	1	0.900	-	-		OOG6_103478
Panther	1	1.100	-	-	LDO	PTHR13003
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R849
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.830