DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup107 and NUP107

DIOPT Version :9

Sequence 1:	NP_609446.1	Gene:	Nup107 / 34481	FlyBaseID:	FBgn0027868	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_065134.1	Gene:	NUP107 / 57122	HGNCID:	29914	Length:	925	Species:	Homo sapiens

Alignment Length:	855	Identity:	293/855 - (34%)
Similarity:	452/855 - (52%)	Gaps:	67/855 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSRSGLLRTTLNSSMPPQNLSHSLLILEKSNAEQNELSLMEDTGDDLDRGKSRMDVLFPQFFDVL 73
            |.||||...|     .|.:::..:.|        :.:.|.||     |.|::   .....|.|.|
Human   116 SQRSGLFTNT-----EPHSITEDVTI--------SAVMLRED-----DPGEA---ASMSMFSDFL 159

  Fly    74 QA--QGNGQEAFEVIQSLTQVCRGVVEQLELEIDHGMGGEQGARQRESMLTWLRQEINTWRLLHA 136
            |:  :.:....|::::....:|...|..|...:.....|.|...:..|||..|:||:.|||||.:
Human   160 QSFLKHSSSTVFDLVEEYENICGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVTWRLLAS 224

  Fly   137 LFYDRILLQTDRQADDEMQDGPT-LGGSEKEVIQQLYALNATLREYQLVVDWLE--ACYDRGEQQ 198
            |:.|||    ....::|.....| :..|||.|::.|:..::.:|:.||||||||  |..:.||..
Human   225 LYRDRI----QSALEEESVFAVTAVNASEKTVVEALFQRDSLVRQSQLVVDWLESIAKDEIGEFS 285

  Fly   199 NPLHAHDRMMAWENTLFQLENLQGAAF-GKGHKIVTRLDPDAPVREKRPLHALDEEDNLRLSRAI 262
            :.:..:.:.:.|||||..|:..|..:: |....:||.||||||:|:|.||..||.||.:||.:.:
Human   286 DNIEFYAKSVYWENTLHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMPLDDLDREDEVRLLKYL 350

  Fly   263 FELIRAGRVDDGLKLCKHFGQTWRAAILEGWRLHEDPNFEQNVSVLHEKLPIEGNPRRDIWKRCA 327
            |.|||||..::..:|||..||.||||.||||:|:.|||.....    |..|:||||.|.|||...
Human   351 FTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGT----ELEPVEGNPYRRIWKISC 411

  Fly   328 WMLADSKNYDEYSRATAGVFSGHLGSLKTLLH--SNWHDLLWAHLKVQIDIRVESEIRG--CCLK 388
            |.:|:.:.::.|.||   :::...|:||.||.  ..|.|.:||:.:|.:|..||.||:.  ..|.
Human   412 WRMAEDELFNRYERA---IYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLD 473

  Fly   389 NYQPMPDDYWNGRMTMEQIFEELNVAKDASVRDFAQSQLGIIQRHLILDTCGELIQHMVRWVEKD 453
            ..:.:|.:|.....|:|::||||.......|.:..|....|:|:.|||.....|:....:|:.|.
Human   474 ETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLILGDIDGLMDEFSKWLSKS 538

  Fly   454 TSQQSPHQLRFMAHIVLFLRQIGRVEQERQAEKIVAAYVEALIARGEPQLIAYYTASLSNPLQVQ 518
            .:....|.||||.|::||.|.:|...:|..:.:::..|::.||......|||:||..|...|.|.
Human   539 RNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVA 603

  Fly   519 LYSRFLEQVEQKRPRELAVDAALQAGLDVEQITRVTVQNIRLAHQPLGEFGEP------QSGEIS 577
            .|:.|||.|.:...|...::.|.:|.|||..||:..|:|||  .:..|||...      .:|...
Human   604 QYALFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIR--KKDNGEFSHHDLAPALDTGTTE 666

  Fly   578 AIDQRKISALEWLIHLPEQRGELLWQANAMIRTYLASSKVECMRQTFRMVPADIVQQLVSL---Y 639
            . |:.||..::||:..|.||.|.|.|.||::|.:|||.|.|..::.|..:|.|.:.::.:.   .
Human   667 E-DRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQ 730

  Fly   640 GSVDNIPPREECCLKEYLCYKAYLSGVDSFVEWNRLQQNRPKKPQTSHAASSQDNFTERMASERK 704
            |....:|..::..::|:||.:|||...::|.||.:...:.|:||    |...|..|||::|.|.|
Human   731 GMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKP----ALIPQPTFTEKVAHEHK 791

  Fly   705 EQAHRSEVVRWEHKVKEQAKQTIELLYNVLMFPDKGWLVDPFIAKLPENAVQLSWDH-RLLQMEK 768
            |:.:..:...|:..:........|.:||||:|.|.||:||     :.|:|.:   || |..||..
Human   792 EKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVD-----VREDAKE---DHERTHQMVL 848

  Fly   769 LRSICIPEIALFLNEVMFKSGDFAGCVRLADEISSENRQLYKVYTKHKLAELLAKIADASLELLN 833
            ||.:|:|.:...|:.::..:|.:..|::|||.:|||..:||.|::|.:|.:||.|:.::||.||:
Human   849 LRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLD 913

  Fly   834 SKLDPWGYPI 843
            ..|||.||.|
Human   914 QGLDPLGYEI 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup107	NP_609446.1	Nup84_Nup100	121..828	CDD:309305	258/724 (36%)
NUP107	NP_065134.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..66
NUP107	NP_065134.1	Nup84_Nup100	209..908	CDD:397996	258/724 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144859
Domainoid	1	1.000	436	1.000	Domainoid score	I574
eggNOG	1	0.900	-	-		E1_KOG1964
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5555
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1548
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56116
OrthoDB	1	1.010	-	-		D277935at33208
OrthoFinder	1	1.000	-	-		FOG0005073
OrthoInspector	1	1.000	-	-		oto88391
orthoMCL	1	0.900	-	-		OOG6_103478
Panther	1	1.100	-	-	LDO	PTHR13003
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R849
SonicParanoid	1	1.000	-	-		X4111
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800