DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC3 and EMC3

DIOPT Version :9

Sequence 1:	NP_609444.1	Gene:	EMC3 / 34479	FlyBaseID:	FBgn0032292	Length:	247	Species:	Drosophila melanogaster
Sequence 2:	NP_012715.3	Gene:	EMC3 / 853628	SGDID:	S000001690	Length:	253	Species:	Saccharomyces cerevisiae

Alignment Length:	258	Identity:	83/258 - (32%)
Similarity:	130/258 - (50%)	Gaps:	33/258 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLIDPDIRVWVFLPIVLITFLVGIVRHYVSILIS------TQKKAEITQIQDSQAMIRARLLREN 62
            :|:|..::.||.|||.::..|.|:::.|:..||:      .|.:.::|:.|..|   .|:||..|
Yeast     1 MLLDDQLKYWVLLPISIVMVLTGVLKQYIMTLITGSSANEAQPRVKLTEWQYLQ---WAQLLIGN 62

  Fly    63 GKYLSAQSFSMRKNYF---NNEETGYFKTQKR-------APVAQNSSAM---LTDMVKGNFINVL 114
            |..||:.:|:.:|.:.   ..||....|.:::       .|...|..:|   :.:|.|||..:.:
Yeast    63 GGNLSSDAFAAKKEFLVKDLTEERHLAKAKQQDGSQAGEVPNPFNDPSMSNAMMNMAKGNMASFI 127

  Fly   115 PMVVIGGWINWMFSGFVTTKVPFPLTLRFKPMLQRGVELASLDAAWVSSASWYFLNVFGLRSIYT 179
            |..:|..|:|..|:||:..::|||||.:||.|||.|:....||..||||.||||::|.||..:|.
Yeast   128 PQTIIMWWVNHFFAGFILMQLPFPLTAKFKEMLQTGIICQDLDVRWVSSISWYFISVLGLNPVYN 192

  Fly   180 LVLGENNHADQTQAQADAMTGAAMTMPQDP-----KAAFKAEWEALEITEYHNALKNIDADML 237
            |: |.|:.....||......|     ||.|     ..|..|....|.|.::...|.|::..:|
Yeast   193 LI-GLNDQDMGIQAGIGGPQG-----PQGPPQSQVDKAMHAMANDLTIIQHETCLDNVEQRVL 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC3	NP_609444.1	DUF106	3..185	CDD:396507	69/199 (35%)
EMC3	NP_012715.3	DUF106	2..194	CDD:396507	72/210 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346264
Domainoid	1	1.000	121	1.000	Domainoid score	I1251
eggNOG	1	0.900	-	-		E1_KOG3188
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10201
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53712
OrthoFinder	1	1.000	-	-		FOG0003058
OrthoInspector	1	1.000	-	-		oto99813
orthoMCL	1	0.900	-	-		OOG6_102473
Panther	1	1.100	-	-	LDO	PTHR13116
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1973
SonicParanoid	1	1.000	-	-		X2419
TreeFam	0	0.000	Not matched by this tool.
	14	13.830