DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC3 and emc-3

DIOPT Version :9

Sequence 1:	NP_609444.1	Gene:	EMC3 / 34479	FlyBaseID:	FBgn0032292	Length:	247	Species:	Drosophila melanogaster
Sequence 2:	NP_502575.1	Gene:	emc-3 / 178300	WormBaseID:	WBGene00013378	Length:	234	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	143/234 - (61%)
Similarity:	182/234 - (77%)	Gaps:	5/234 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTELLIDPDIRVWVFLPIVLITFLVGIVRHYVSILISTQKKAEITQIQDSQAMIRARLLRENGKY 65
            ||:||:||.||.|||||||:|||.:||:|||||:|:..:||.|:..|.|.|.::|||||||||::
Worm     1 MTDLLLDPAIRTWVFLPIVVITFFIGILRHYVSLLLMNKKKVELENIADGQYLLRARLLRENGRF 65

  Fly    66 LSAQSFSMRKNYFNNEETGYF-KTQKRAPVAQN--SSAMLTDMVKGNFINVLPMVVIGGWINWMF 127
            |...||:.|:.|...|||||. |.|:|.....|  ..:.:|:|:|||.:|::||:|:||||||.|
Worm    66 LPKTSFNARRQYLCAEETGYLSKAQQRPAKGPNPMDPSQMTEMLKGNMMNMIPMIVVGGWINWTF 130

  Fly   128 SGFVTTKVPFPLTLRFKPMLQRGVELASLDAAWVSSASWYFLNVFGLRSIYTLVLGENNHADQTQ 192
            ||||||:|||||||:||.||||||:|.|||:|||||||||||.:||||||||||||..|.|||::
Worm   131 SGFVTTRVPFPLTLKFKAMLQRGVDLVSLDSAWVSSASWYFLCMFGLRSIYTLVLGSENAADQSK 195

  Fly   193 AQAD--AMTGAAMTMPQDPKAAFKAEWEALEITEYHNAL 229
            |..|  ||||:|:....||:||||.|||||::.::..||
Worm   196 AMEDQMAMTGSAVNPQADPRAAFKGEWEALQMIQHQFAL 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC3	NP_609444.1	DUF106	3..185	CDD:396507	117/184 (64%)
emc-3	NP_502575.1	DUF106	3..188	CDD:280185	117/184 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166766
Domainoid	1	1.000	247	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_KOG3188
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10201
Inparanoid	1	1.050	292	1.000	Inparanoid score	I1684
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53712
OrthoDB	1	1.010	-	-		D1482782at2759
OrthoFinder	1	1.000	-	-		FOG0003058
OrthoInspector	1	1.000	-	-		oto20196
orthoMCL	1	0.900	-	-		OOG6_102473
Panther	1	1.100	-	-	LDO	PTHR13116
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1973
SonicParanoid	1	1.000	-	-		X2419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840