Protein Alignment CG6431 and LPL

DIOPT Version :10

• Sequence 1: NP_001188790.1
• Gene: CG6431 / 34476
• FlyBaseID: FBgn0032289
• Length: 351
• Species: Drosophila melanogaster
• Sequence 2: NP_000228.1
• Gene: LPL / 4023
• HGNCID: 6677
• Length: 475
• Species: Homo sapiens
• Alignment Length: 249
• Identity: 76/249 - (30%)
• Similarity: 109/249 - (43%)
• Gaps: 44/249 - (17%)

  Fly    90 FSKHRETVFIIHGFNGTAI-DIHLQFLRDAYLSR--DFNVITVDW--RPLTRYPCYLHSLINTRL 149
            |:...:|..:|||:..|.: :..:..|..|...|  |.|||.|||  |....||.   |...|:|
Human    69 FNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPV---SAGYTKL 130

  Fly   150 TAQCTAQIYAFL-THYGAVRERITCVGHSLGAHICGMISNHLTRKQYRIIGLDPARPLIERMKSN 213
            ..|..|:...:: ..:....:.:..:|:|||||..|:..:...:|..||.|||||.|..|..::.
Human   131 VGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAP 195

  Fly   214 KFRLSIDDANVIQVLHT----NAG-FLGQEDNSGHLNYCVNGGRIQPFCK-GNPIR--------- 263
            . |||.|||:.:.||||    :.| .:|.:...||::...|||..||.|. |..||
Human   196 S-RLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGD 259

  Fly   264 ---KSRCSHFLSI---------------CYLATATFKHNKFMGVPC-PNGCLNL 298
               ..:|||..||               .|..::.....|.:.:.| .|.|.||
Human   260 VDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6431	NP_001188790.1	alpha/beta hydrolases	63..293	CDD:473884	72/242 (30%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189	32..53
		lipo_lipase	33..473	CDD:132274	76/249 (31%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	243..266		4/22 (18%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189	443..467