Protein Alignment CG6431 and Lpl

DIOPT Version :10

• Sequence 1: NP_001188790.1
• Gene: CG6431 / 34476
• FlyBaseID: FBgn0032289
• Length: 351
• Species: Drosophila melanogaster
• Sequence 2: NP_032535.2
• Gene: Lpl / 16956
• MGIID: 96820
• Length: 474
• Species: Mus musculus
• Alignment Length: 249
• Identity: 75/249 - (30%)
• Similarity: 107/249 - (42%)
• Gaps: 44/249 - (17%)

  Fly    90 FSKHRETVFIIHGFNGTAI-DIHLQFLRDAYLSR--DFNVITVDW--RPLTRYPCYLHSLINTRL 149
            |:...:|..:|||:..|.: :..:..|..|...|  |.|||.|||  |....||.   |...|:|
Mouse    69 FNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPV---SAGYTKL 130

  Fly   150 TAQCTAQIYAFL-THYGAVRERITCVGHSLGAHICGMISNHLTRKQYRIIGLDPARPLIERMKSN 213
            .....|:...:: ..:....:.:..:|:|||||..|:..:...:|..||.|||||.|..|..::.
Mouse   131 VGNDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAP 195

  Fly   214 KFRLSIDDANVIQVLHT----NAG-FLGQEDNSGHLNYCVNGGRIQPFCK-GNPIR--------- 263
            . |||.|||:.:.||||    :.| .:|.:...||::...|||..||.|. |..||
Mouse   196 S-RLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGD 259

  Fly   264 ---KSRCSHFLSI---------------CYLATATFKHNKFMGVPC-PNGCLNL 298
               ..:|||..||               .|...:.....|.:.:.| .|.|.||
Mouse   260 VDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6431	NP_001188790.1	alpha/beta hydrolases	63..293	CDD:473884	71/242 (29%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	32..53
		lipo_lipase	33..472	CDD:132274	75/249 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858	243..266		4/22 (18%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	443..467