DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6415 and Dmgdh

DIOPT Version :9

Sequence 1:	NP_609441.1	Gene:	CG6415 / 34474	FlyBaseID:	FBgn0032287	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_083048.1	Gene:	Dmgdh / 74129	MGIID:	1921379	Length:	869	Species:	Mus musculus

Alignment Length:	337	Identity:	95/337 - (28%)
Similarity:	166/337 - (49%)	Gaps:	22/337 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RQVGSIFDVSHMLQSRIFGKDAAACLESVCTADILGTPE-GSGSLTVFTNEAGGILDDLIVNKVS 129
            ::|| :.|:|...:..|.|:|:...|:.: .|:::  |: |..:::......|.:..:|.|::.|
Mouse   520 QRVG-VIDLSPFGKFNIKGRDSTQLLDHL-FANVI--PKVGFTNISHMLTPRGRVYAELTVSQQS 580

  Fly   130 EKELYVVSNAAMKEQDMGIMKTAVDNFKSQGKDVSIEFLTPADQSLVAVQGPQVAKELSKLLTGK 194
            ..|..:::.:..:..|:..::.|.  |:. |.||.|:.:|. :..::.|.||...:.|.||.:..
Mouse   581 PGEFLLITGSGSELHDLRWIEEAA--FRG-GYDVEIQNITD-EFGVLGVAGPYARRVLQKLTSED 641

  Fly   195 ASLDQLYFMSSFVTTLAGIPNVRITRCGYTGEDGVEISVASSQAQKLTESLLESGVLKLAGLG-- 257
            .|.|...|:.:....::.|| |...|..||||.|.|:......:..|.|.::.:|  :..|:|
Mouse   642 LSDDAFKFLQTKSFNISDIP-VTAIRISYTGELGWELYHRREDSATLYERIMSAG--QEEGIGDF 703

  Fly   258 ---ARDSLRLEAGLCLYGSDIDSKTTPVEAALAWLVTKRRRTTRDFPGADVILGQLK-EGVSRRR 318
               |.::||||.....:||:::..|.|:||.|.:.|  :.....||.|... |.|:| ||:.||.
Mouse   704 GTYALNALRLEKAFRAWGSEMNCDTNPLEAGLEYFV--KLNKPADFIGKQA-LKQIKTEGLKRRL 765

  Fly   319 VGLQMLGTKPPPARSGVAIFSQGQQVGQVTSGCPSPSAGRNIAMGYVAENLKAPGTKVEFKVRDK 383
            |.| .:.|.........:|:.:|:.||..|||..|.|..:::|..||...|...|.:||.::..|
Mouse   766 VCL-TVATDDVDPEGNESIWYKGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGK 829

  Fly   384 LYEAEVTKMPFV 395
            .|.|.:.:.|.|
Mouse   830 NYPATIIQEPLV 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6415	NP_609441.1	PLN02319	3..403	CDD:177953	95/337 (28%)
		GCV_T	31..288	CDD:279857	60/227 (26%)
		GCV_T_C	298..392	CDD:285832	32/94 (34%)
Dmgdh	NP_083048.1	NADB_Rossmann	38..>83	CDD:304358
		DadA	40..428	CDD:223737
		FAO_M	410..465	CDD:292961
		GCV_T	475..738	CDD:279857	60/228 (26%)
		GcvT	481..850	CDD:223481	95/337 (28%)
		GCV_T_C	746..838	CDD:285832	32/93 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810