DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6415 and SARDH

DIOPT Version :9

Sequence 1:	NP_609441.1	Gene:	CG6415 / 34474	FlyBaseID:	FBgn0032287	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001128179.1	Gene:	SARDH / 1757	HGNCID:	10536	Length:	918	Species:	Homo sapiens

Alignment Length:	414	Identity:	98/414 - (23%)
Similarity:	165/414 - (39%)	Gaps:	62/414 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSYRLPAALGGLRHASSAAGEGQRTALYDFHVQKGGKIVNFGGYALPVQYSDQSIIASHLHTRQV 68
            |.|....|.|...|...|    .|..|.|.:.           :|.|..:  .:|....|..|..
Human   520 LEYDYYGAYGSRAHEDYA----YRRLLADEYT-----------FAFPPHH--DTIKKECLACRGA 567

  Fly    69 GSIFDVSHMLQSRIFGKDAAACLESVCTADILGTPEGSGSLTVFTNEAGGILDDLIVNKVSEKE- 132
            .::||:|:..:..:.|.||....:.:.:||: ..|.||...|...|..||...||.|::::...
Human   568 AAVFDMSYFGKFYLVGLDARKAADWLFSADV-SRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQ 631

  Fly   133 ------------LYVVSNAAMKEQDMGIMKTAVDNFKSQGKDVSIEFLTPADQSLVAVQGPQVAK 185
                        .|:....|:.:.:...:.|.:.:.|||.:.:.    :..|..::::|||....
Human   632 ASPLAPAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLID----SSEDLGMISIQGPASRA 692

  Fly   186 ELSKLLTGKASLDQLYFMSSFVTTLAGIPNVRITRCGYTGEDGVEISVASSQAQKLTESLLESGV 250
            .|.::|....|.:...|.:..:...|| ..||..|..:.||.|.|:.:..:....:..:::.:|.
Human   693 ILQEVLDADLSNEAFPFSTHKLLRAAG-HLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGA 756

  Fly   251 ---LKLAGLGARDSLRLEAGLCLYGSDIDSKTTPVEAALAWLVTKRRRTTRDFPGADVILGQLKE 312
               |..||..|.|||.:|.|...:.:|:....:|:||.||:  |.:.::...|.|.:.:..|...
Human   757 KHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAF--TCKLKSPVPFLGREALEQQRAA 819

  Fly   313 GVSRRRVGLQMLGTKPPPARSGV-AIFSQGQQVGQVTSGCPSPSAGRNIAMGYVAENLKAPGTKV 376
            |:.||.|...|....|   ..|: ||:..||.||.|.......:..:.||.||:.:....|
Human   820 GLRRRLVCFTMEDKVP---MFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGP---- 877

  Fly   377 EFKVRDKLYEAEVTKMPFVKANYY 400
                         ..:.|||:..|
Human   878 -------------VSLDFVKSGDY 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6415	NP_609441.1	PLN02319	3..403	CDD:177953	98/414 (24%)
		GCV_T	31..288	CDD:279857	62/272 (23%)
		GCV_T_C	298..392	CDD:285832	22/94 (23%)
SARDH	NP_001128179.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		DadA	63..447	CDD:223737
		FAO_M	430..485	CDD:292961
		GcvT	479..916	CDD:223481	98/414 (24%)
		GCV_T	489..798	CDD:279857	71/302 (24%)
		GCV_T_C	807..>871	CDD:285832	21/66 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810