DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31871 and TGL1

DIOPT Version :9

Sequence 1:	NP_723607.1	Gene:	CG31871 / 34463	FlyBaseID:	FBgn0051871	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_012782.1	Gene:	TGL1 / 853717	SGDID:	S000001623	Length:	548	Species:	Saccharomyces cerevisiae

Alignment Length:	462	Identity:	125/462 - (27%)
Similarity:	197/462 - (42%)	Gaps:	94/462 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ETHTVVTKDGYILEMHRIP-----KKGAQPVLLMHGILDTSATWVL-MGPKSGLGYMLSDLGYDV 149
            |.|.|.|:|.|||.:||||     :...:.|.|.||:|..|..|.. :.....|.::|.||||||
Yeast    78 EDHLVRTEDNYILTLHRIPPISKNRFNNKVVYLHHGLLMCSDVWCCNIERHKNLPFVLHDLGYDV 142

  Fly   150 WMGNSRGNRYSKNHTSLNSDYQEFWDFTFHEMGKYDLPANIDYILSKTGYEQVHYIGHSQGTAIF 214
            ||||:|||:||..|.:......:||||:..|...:|:|.:|::||..|..::|..||.|||:|..
Yeast   143 WMGNNRGNKYSTAHLNKPPKSNKFWDFSIDEFAFFDIPNSIEFILDITKVDKVICIGFSQGSAQM 207

  Fly   215 WVLCSEQPAYTQKITSMHALAPIAYIHDMKSPLFRTLVLFLDFLTAATRMLRITEFMPNTKFLVD 279
            :...|......:|::...|:||......:.:.:..||                .:..|...:|..
Yeast   208 FAAFSLSEKLNRKVSHFIAIAPAMTPKGLHNRIVDTL----------------AKSSPGFMYLFF 256

  Fly   280 HSQVVCHDNAMTQ------------DVCSNILFLVAGYNSEQLNKTMLPVMLSHTPSGASIKQLE 332
            ..::|.....:.|            |:.:.|||....:|.....|......|..|   .|:|.:.
Yeast   257 GRKIVLPSAVIWQRTLHPTLFNLCIDIANKILFNWKSFNILPRQKIASYAKLYST---TSVKSIV 318

  Fly   333 HFGQLMKSGHFRKFDRGYLRNQLEYNRMTPPDYDL------SRVKVPVALYYSVNDLLVSTTGVD 391
            |:.|:::|..|:.|:..  .|.|  |.:|.| |.:      :.:|:|:.|.|...|.||.   :|
Yeast   319 HWFQILRSQKFQMFEES--DNML--NSLTRP-YQIANFPTRTNIKIPILLIYGGIDSLVD---ID 375

  Fly   392 RLARELP--NVIDKYLVPMERFNHLDFLWAIDVKPLVYNRLVRNVRRVENHRAKLTANLANYLAM 454
            .:.:.||  :|.|   |.::.:.|||.:|..|...||..:::|.:.........:..|
Yeast   376 VMKKNLPFNSVFD---VKVDNYEHLDLIWGKDADTLVIAKVLRFIEFFNPGNVSVKTN------- 430

  Fly   455 QLQRQQLRQQMQQQMMEGLPPNVHLPHGLGMEMLARATTFAPVTHPTTTMTMPTTTTEN------ 513
                 ||..  ...::|.||                :||: ..||||..::..|.:.:.
Yeast   431 -----QLLP--SASLVEELP----------------STTW-KTTHPTHGLSYRTHSADRSPLSVQ 471

  Fly   514 -DAEDEV 519
             |..|||
Yeast   472 ADEADEV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31871	NP_723607.1	Abhydro_lipase	79..133	CDD:282003	19/47 (40%)
		MhpC	93..436	CDD:223669	107/368 (29%)
		Abhydrolase_5	115..281	CDD:289465	52/166 (31%)
TGL1	NP_012782.1	Abhydro_lipase	66..124	CDD:397965	19/45 (42%)
TGL1	NP_012782.1	Abhydrolase_1	106..402	CDD:395444	91/325 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I1418
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I1188
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		otm46497
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
TreeFam	0	0.000	Not matched by this tool.
	11	10.800