DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31871 and LIPN

DIOPT Version :9

Sequence 1:	NP_723607.1	Gene:	CG31871 / 34463	FlyBaseID:	FBgn0051871	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	398	Identity:	141/398 - (35%)
Similarity:	219/398 - (55%)	Gaps:	25/398 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LLNSVLLSSNPNLAGGGRNLKSDVLEDASLITPKLIRKYGYPSETHTVVTKDGYILEMHRIP--- 109
            ||.:..|......|||..:|:::|..:..:.|.::|...|||||.:.|.|:|||||.::|||
Human     5 LLTTTCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGR 69

  Fly   110 ----KKGAQPVLLM-HGILDTSATWVLMGPKSGLGYMLSDLGYDVWMGNSRGNRYSKNHTSLNSD 169
                ..|.:||:.| |.:...:|.|:.......||::|:|.||||||||||||.:|:.|.:|:..
Human    70 THARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSET 134

  Fly   170 YQEFWDFTFHEMGKYDLPANIDYILSKTGYEQVHYIGHSQGTAIFWVLCSEQPAYTQKITSMHAL 234
            .::||.|:|.||.|||||..||:|::|||.|::::||||.||.|.:|..|..|...|:|....||
Human   135 DEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFAL 199

  Fly   235 APIAYIHDMKSPLFRTLVLFLDFLTAATRMLRITEFMPNTKFLVDH-----SQVVCHDNAMTQDV 294
            .|..   ..|.|    ..:|..|......:::.. |.....||.|.     |..:| :|.:...:
Human   200 GPTI---SFKYP----TGIFTRFFLLPNSIIKAV-FGTKGFFLEDKKTKIASTKIC-NNKILWLI 255

  Fly   295 CSNILFLVAGYNSEQLNKTMLPVMLSHTPSGASIKQLEHFGQLMKSGHFRKFDRGY-LRNQLEYN 358
            ||..:.|.||.|.:.:|::.:.|.:||.|:|:|:..:.|..||..|..||.:|.|. ..|...||
Human   256 CSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYN 320

  Fly   359 RMTPPDYDLSRVKVPVALYYSVNDLLVSTTGVDRLARELPNVIDKYLVPMERFNHLDFLWAIDVK 423
            :..||.|||:.:|||.|::...:|:||:...|.|:..::.::  .|...:..:||.||:|.:|..
Human   321 QSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSL--HYFKLLPDWNHFDFVWGLDAP 383

  Fly   424 PLVYNRLV 431
            ..:|:.::
Human   384 QRMYSEII 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31871	NP_723607.1	Abhydro_lipase	79..133	CDD:282003	24/61 (39%)
		MhpC	93..436	CDD:223669	126/353 (36%)
		Abhydrolase_5	115..281	CDD:289465	66/171 (39%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	24/60 (40%)
		Abhydrolase_1	79..379	CDD:278959	112/310 (36%)
		Abhydrolase	106..>175	CDD:304388	39/68 (57%)
		Abhydrolase	<149..>234	CDD:304388	31/92 (34%)
		Abhydrolase_5	<322..374	CDD:289465	16/53 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141817
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910